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Normal human CD4(+) helper T cells express Kv1.1 voltage-gated K(+) channels, and selective Kv1.1 block in T cells induces by itself robust TNFα production and secretion and activation of the NFκB non-canonical pathway.
Fellerhoff-Losch B, Korol SV, Ganor Y, Gu S, Cooper I, Eilam R, Besser M, Goldfinger M, Chowers Y, Wank R, Birnir B, Levite M. Fellerhoff-Losch B, et al. Among authors: besser m. J Neural Transm (Vienna). 2016 Mar;123(3):137-57. doi: 10.1007/s00702-015-1446-9. Epub 2015 Nov 26. J Neural Transm (Vienna). 2016. PMID: 26611796
Systemic dysregulation of CEACAM1 in melanoma patients.
Markel G, Ortenberg R, Seidman R, Sapoznik S, Koren-Morag N, Besser MJ, Bar J, Shapira R, Kubi A, Nardini G, Tessone A, Treves AJ, Winkler E, Orenstein A, Schachter J. Markel G, et al. Cancer Immunol Immunother. 2010 Feb;59(2):215-30. doi: 10.1007/s00262-009-0740-5. Cancer Immunol Immunother. 2010. PMID: 19633846
370 results