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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1976 8
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1983 57
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1985 83
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1988 49
1989 55
1990 83
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1992 70
1993 58
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1998 37
1999 34
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2002 38
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2005 26
2006 31
2007 27
2008 29
2009 24
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2011 40
2012 33
2013 17
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1,669 results

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Page 1
Bestatin as an experimental tool in mammals.
Scornik OA, Botbol V. Scornik OA, et al. Curr Drug Metab. 2001 Mar;2(1):67-85. doi: 10.2174/1389200013338748. Curr Drug Metab. 2001. PMID: 11465152 Review.
Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some, but not all aminopeptidases. ...Finally bestatin-sensitive LTA4 hydrolase generates the potent chemotactic agent, LTB4....
Bestatin, an antibiotic of microbial origin, is a potent inhibitor of some, but not all aminopeptidases. ...Finally bestatin-s …
Bestatin as a treatment modality in experimental periodontitis.
Kaminska M, Benedyk-Machaczka M, Adamowicz K, Aliko A, Drzazga K, Słysz K, Bielecka E, Potempa J, Mydel P. Kaminska M, et al. J Periodontol. 2023 Nov;94(11):1338-1350. doi: 10.1002/JPER.22-0614. Epub 2023 Apr 25. J Periodontol. 2023. PMID: 37021727
Our objective was to evaluate antimicrobial effects of bestatin, a potential CP drug candidate. METHODS: We evaluated bestatin bacteriostatic efficiency against periodontopathogens in planktonic cultures via microplate assay, and mono- and multispecies oral biofilm …
Our objective was to evaluate antimicrobial effects of bestatin, a potential CP drug candidate. METHODS: We evaluated bestatin …
Bestatin, an aminopeptidase inhibitor with a multi-pharmacological function.
Mathé G. Mathé G. Biomed Pharmacother. 1991;45(2-3):49-54. doi: 10.1016/0753-3322(91)90122-a. Biomed Pharmacother. 1991. PMID: 1912369 Review.
Bestatin, the dipeptide N-((2S, 3R)-3-amino-2-hydroxy-4-phenyl butanyl) L-leucine is a leucine aminopeptidase and aminopeptidase-B inhibitor. ...It stimulates granulocytopoiesis and thrombocytopoiesis in vitro, and can restore them in vivo in myelo-hypoplastic man. The ant …
Bestatin, the dipeptide N-((2S, 3R)-3-amino-2-hydroxy-4-phenyl butanyl) L-leucine is a leucine aminopeptidase and aminopeptidase-B in …
Review of ubenimex (Bestatin): clinical research.
Ota K. Ota K. Biomed Pharmacother. 1991;45(2-3):55-60. doi: 10.1016/0753-3322(91)90123-b. Biomed Pharmacother. 1991. PMID: 1912370 Review.
An immunomodulating agent, ubenimex (Bestatin) has low toxicity even after long-term oral administration and brings about significant modifications in immunological response. In a cooperative randomized controlled study of Bestatin immunotherapy for adult acu …
An immunomodulating agent, ubenimex (Bestatin) has low toxicity even after long-term oral administration and brings about sign …
FASN Inhibitors Enhance Bestatin-Related Tumor Cell Apoptosis Through Upregulating PEPT1.
Ni J, Shang Y, Wang WD, Wang C, Wang AM, Li GJ, Chen SZ. Ni J, et al. Curr Mol Pharmacol. 2023;16(7):771-786. doi: 10.2174/1874467216666221121121549. Curr Mol Pharmacol. 2023. PMID: 36411574
RESULTS: In the current study, we found that inhibiting FASN by cerulenin and orlistat both augmented the effects of bestatin in decreasing tumor cell viability. Cerulenin increased the apoptosis rates and enhanced the cleavage of PARP caused by bestatin. ...CONCLUS …
RESULTS: In the current study, we found that inhibiting FASN by cerulenin and orlistat both augmented the effects of bestatin in decr …
Effects of Bestatin on hematopoiesis in long-term human bone marrow cultures.
Fujisaki T, Otsuka T, Takamatsu Y, Eto T, Harada M, Niho Y. Fujisaki T, et al. Biomed Pharmacother. 1995;49(2):69-74. doi: 10.1016/0753-3322(96)82589-3. Biomed Pharmacother. 1995. PMID: 7605904 Review.
The effects of Bestatin (Ubenimex, UBX) on normal hematopoiesis were investigated using long-term bone marrow cultures (LTBMC) to determine whether it might enhance hematopoiesis over a long period, as well as induce the release of cytokines. ...
The effects of Bestatin (Ubenimex, UBX) on normal hematopoiesis were investigated using long-term bone marrow cultures (LTBMC) …
Clinical trials of bestatin for leukemia and solid tumors.
Ota K, Uzuka Y. Ota K, et al. Biotherapy. 1992;4(3):205-14. doi: 10.1007/BF02174207. Biotherapy. 1992. PMID: 1599804 Review.
A new immunomodulating agent, bestatin (INN: ubenimex) has low toxicity after long-term oral administration and significantly modifies immunological responses. ...However, the adjuvant activity of bestatin immunotherapy for these cancers should be further inv …
A new immunomodulating agent, bestatin (INN: ubenimex) has low toxicity after long-term oral administration and significantly …
LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.
Gao JJ, Xue X, Gao ZH, Cui SX, Cheng YN, Xu WF, Tang W, Qu XJ. Gao JJ, et al. Microvasc Res. 2011 Sep;82(2):122-30. doi: 10.1016/j.mvr.2011.05.008. Epub 2011 Jun 12. Microvasc Res. 2011. PMID: 21664364 Review.
Our previous study revealed that LYP, a bestatin dimethylaminoethyl ester, inhibited the growth of human ovarian carcinoma ES-2 xenografts in mice and suppressed aminopeptidase N (APN/CD13) activity more potently than bestatin. ...LYP suppression of cancer angiogene …
Our previous study revealed that LYP, a bestatin dimethylaminoethyl ester, inhibited the growth of human ovarian carcinoma ES-2 xenog …
Progress in the development of bestatin analogues as aminopeptidases inhibitors.
Chen L, Teng Y, Xu W. Chen L, et al. Curr Med Chem. 2011;18(7):964-76. doi: 10.2174/092986711794940879. Curr Med Chem. 2011. PMID: 21254977 Review.
This review will focus on an effective inhibitor of aminopeptidases, bestatin, including work to find better inhibitors in the past three decades that has sought to optimize bestatin and prospective developments in bestatin optimization in the future....
This review will focus on an effective inhibitor of aminopeptidases, bestatin, including work to find better inhibitors in the past t …
Why Bestatin Prefers Human Carnosinase 2 (CN2) to Human Carnosinase 1 (CN1).
Toviwek B, Koonawootrittriron S, Suwanasopee T, Jattawa D, Pongprayoon P. Toviwek B, et al. J Phys Chem B. 2024 Dec 5;128(48):11876-11884. doi: 10.1021/acs.jpcb.4c05571. Epub 2024 Nov 22. J Phys Chem B. 2024. PMID: 39574306 Free PMC article.
CNs contain a catalytic metal ion pair (Zn(2+) for CN1 and Mn(2+) for CN2) and two subpockets (S1 and S1' pockets) to accommodate a substrate. Bestatin (BES) has been reported to be active for CN2; however, its inhibition ability for CN1 has remained under debate, because …
CNs contain a catalytic metal ion pair (Zn(2+) for CN1 and Mn(2+) for CN2) and two subpockets (S1 and S1' pockets) to accommodate a substrat …
1,669 results