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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1980 1
1982 1
1984 1
1985 1
1988 1
1989 3
1990 1
1991 4
1993 6
1994 1
1995 3
1996 4
1997 2
1998 7
1999 2
2000 4
2001 7
2002 5
2003 6
2004 1
2005 8
2006 2
2007 7
2008 12
2009 3
2010 7
2011 6
2012 11
2013 8
2014 6
2015 7
2016 19
2017 15
2018 11
2019 5
2020 4
2021 20
2022 7
2023 7
2024 3

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213 results

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Page 1
beta-Thalassemia.
Origa R. Origa R. Genet Med. 2017 Jun;19(6):609-619. doi: 10.1038/gim.2016.173. Epub 2016 Nov 3. Genet Med. 2017. PMID: 27811859 Free article. Review.
beta-Thalassemia is caused by reduced (beta(+)) or absent (beta(0)) synthesis of the beta-globin chains of hemoglobin. ...Transfusions and oral iron chelation therapy have dramatically improved the quality of life for patients with thalassemi
beta-Thalassemia is caused by reduced (beta(+)) or absent (beta(0)) synthesis of the beta-globin chains o
Beta-thalassemia.
Cao A, Galanello R. Cao A, et al. Genet Med. 2010 Feb;12(2):61-76. doi: 10.1097/GIM.0b013e3181cd68ed. Genet Med. 2010. PMID: 20098328 Free article. Review.
Beta-thalassemia is caused by the reduced (beta) or absent (beta) synthesis of the beta globin chains of the hemoglobin tetramer. ...The clinical severity of beta-thalassemia is related to the extent of imbalance between the
Beta-thalassemia is caused by the reduced (beta) or absent (beta) synthesis of the beta globin chains of
Beta-thalassemia.
Galanello R, Origa R. Galanello R, et al. Orphanet J Rare Dis. 2010 May 21;5:11. doi: 10.1186/1750-1172-5-11. Orphanet J Rare Dis. 2010. PMID: 20492708 Free PMC article. Review.
Beta-thalassemias are caused by point mutations or, more rarely, deletions in the beta globin gene on chromosome 11, leading to reduced (beta+) or absent (beta0) synthesis of the beta chains of hemoglobin (Hb). ...Prognosis for individuals with beta
Beta-thalassemias are caused by point mutations or, more rarely, deletions in the beta globin gene on chromosome 11, leading t
Exagamglogene Autotemcel: First Approval.
Hoy SM. Hoy SM. Mol Diagn Ther. 2024 Mar;28(2):133-139. doi: 10.1007/s40291-024-00696-z. Epub 2024 Jan 17. Mol Diagn Ther. 2024. PMID: 38228954 Review.
Developed by Vertex Pharmaceuticals and CRISPR Therapeutics, exagamglogene autotemcel received its first approval on 16 November 2023 in the UK for the treatment of transfusion-dependent beta-thalassemia (TDT) in patients aged 12 years for whom haematopoietic stem c …
Developed by Vertex Pharmaceuticals and CRISPR Therapeutics, exagamglogene autotemcel received its first approval on 16 November 2023 in the …
Gene Therapy for beta-Hemoglobinopathies: From Discovery to Clinical Trials.
Segura EER, Ayoub PG, Hart KL, Kohn DB. Segura EER, et al. Viruses. 2023 Mar 9;15(3):713. doi: 10.3390/v15030713. Viruses. 2023. PMID: 36992422 Free PMC article. Review.
Extensive characterization of the globin gene locus, accompanied by pioneering work on the utilization of viruses as human gene delivery tools in human hematopoietic stem and progenitor cells (HPSCs), has led to transformative and successful therapies via autologous hematopoietic …
Extensive characterization of the globin gene locus, accompanied by pioneering work on the utilization of viruses as human gene delivery too …
MicroRNAs in beta-thalassemia.
Wang F, Ling L, Yu D. Wang F, et al. Am J Med Sci. 2021 Jul;362(1):5-12. doi: 10.1016/j.amjms.2021.02.011. Epub 2021 Feb 16. Am J Med Sci. 2021. PMID: 33600783 Review.
beta-thalassemia is a lethal inherited disease resulting from beta-globin gene mutations. ...Moreover, changes in the expression of miR-125b, miR-210, miR-451, and miR-609 reflect the severity of anemia and hemolysis in beta-thalassemia p
beta-thalassemia is a lethal inherited disease resulting from beta-globin gene mutations. ...Moreover, changes i
The expanding phenotypes of cohesinopathies: one ring to rule them all!
Piché J, Van Vliet PP, Pucéat M, Andelfinger G. Piché J, et al. Cell Cycle. 2019 Nov;18(21):2828-2848. doi: 10.1080/15384101.2019.1658476. Epub 2019 Sep 13. Cell Cycle. 2019. PMID: 31516082 Free PMC article. Review.
This review focuses on non-cohesion-related functions of the cohesin complex, gene dosage effect, epigenetic regulation and TGF-beta in cohesinopathy context, especially in comparison to Chronic Atrial and Intestinal Dysrhythmia (CAID) syndrome, a very distinct cohe …
This review focuses on non-cohesion-related functions of the cohesin complex, gene dosage effect, epigenetic regulation and TGF-be
Thalassemia in Pakistan.
Khaliq S. Khaliq S. Hemoglobin. 2022 Jan;46(1):12-14. doi: 10.1080/03630269.2022.2059670. Hemoglobin. 2022. PMID: 35950582 Review.
The healthcare delivery system of Pakistan is complex because it includes healthcare subsystems operated by both the federal government and the provincial government. In Pakistan beta-thalassemia (beta-thal) trait frequency ranges between 5.0-7.0%, thus, ther …
The healthcare delivery system of Pakistan is complex because it includes healthcare subsystems operated by both the federal government and …
Sickle cell anemia, the first molecular disease: overview of molecular etiology, pathophysiology, and therapeutic approaches.
Steinberg MH. Steinberg MH. ScientificWorldJournal. 2008 Dec 25;8:1295-324. doi: 10.1100/tsw.2008.157. ScientificWorldJournal. 2008. PMID: 19112541 Free PMC article. Review.
The root cause of sickle cell disease is a single beta-globin gene mutation coding for the sickle beta-hemoglobin chain. ...A multifaceted pathophysiology, triggered by erythrocyte injury induced by the sickle hemoglobin polymer, and encompassing more general …
The root cause of sickle cell disease is a single beta-globin gene mutation coding for the sickle beta-hemoglobin chain …
Iron and infection.
Ganz T. Ganz T. Int J Hematol. 2018 Jan;107(1):7-15. doi: 10.1007/s12185-017-2366-2. Epub 2017 Nov 16. Int J Hematol. 2018. PMID: 29147843 Review.
Iron overload disorders, such as hereditary hemochromatosis or beta-thalassemia, interfere with iron-restrictive host responses, and thereby cause increased susceptibility to infections with microbes that can exploit this vulnerability. Anemia of inflammation (forme …
Iron overload disorders, such as hereditary hemochromatosis or beta-thalassemia, interfere with iron-restrictive host response …
213 results