Bethke TD - Search Results

1

Roflumilast--an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial.

Rabe KF, Bateman ED, O'Donnell D, Witte S, Bredenbröker D, Bethke TD. Rabe KF, et al. Among authors: bethke td. Lancet. 2005 Aug 13-19;366(9485):563-71. doi: 10.1016/S0140-6736(05)67100-0. Lancet. 2005. PMID: 16099292 Clinical Trial.

2

Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD.

Grootendorst DC, Gauw SA, Verhoosel RM, Sterk PJ, Hospers JJ, Bredenbröker D, Bethke TD, Hiemstra PS, Rabe KF. Grootendorst DC, et al. Among authors: bethke td. Thorax. 2007 Dec;62(12):1081-7. doi: 10.1136/thx.2006.075937. Epub 2007 Jun 15. Thorax. 2007. PMID: 17573446 Free PMC article. Clinical Trial.

3

Dose-proportional intraindividual single- and repeated-dose pharmacokinetics of roflumilast, an oral, once-daily phosphodiesterase 4 inhibitor.

Bethke TD, Böhmer GM, Hermann R, Hauns B, Fux R, Mörike K, David M, Knoerzer D, Wurst W, Gleiter CH. Bethke TD, et al. J Clin Pharmacol. 2007 Jan;47(1):26-36. doi: 10.1177/0091270006294529. J Clin Pharmacol. 2007. PMID: 17192499 Clinical Trial.

4

Single-dose pharmacokinetics of roflumilast in children and adolescents.

Neville KA, Szefler SJ, Abdel-Rahman SM, Lahu G, Zech K, Herzog R, Bethke TD, Gleason MC, Kearns GL. Neville KA, et al. Among authors: bethke td. J Clin Pharmacol. 2008 Aug;48(8):978-85. doi: 10.1177/0091270008319466. Epub 2008 May 28. J Clin Pharmacol. 2008. PMID: 18508947 Clinical Trial.

5

Influence of renal impairment on the pharmacokinetics of oral roflumilast: an open-label, parallel-group, single-center study.

Bethke TD, Hartmann M, Hünnemeyer A, Lahu G, Gleiter CH. Bethke TD, et al. Int J Clin Pharmacol Ther. 2011 Aug;49(8):491-9. doi: 10.5414/cp201556. Int J Clin Pharmacol Ther. 2011. PMID: 21781649 Clinical Trial.

6

Roflumilast, a once-daily oral phosphodiesterase 4 inhibitor, lacks relevant pharmacokinetic interactions with inhaled salbutamol when co-administered in healthy subjects.

Bethke TD, Giessmann T, Westphal K, Weinbrenner A, Hauns B, Hauschke D, David M, Lahu G, Zech K, Hermann R, Siegmund W. Bethke TD, et al. Int J Clin Pharmacol Ther. 2006 Nov;44(11):572-9. doi: 10.5414/cpp44572. Int J Clin Pharmacol Ther. 2006. PMID: 17176624 Clinical Trial.

7

The oral, once-daily phosphodiesterase 4 inhibitor roflumilast lacks relevant pharmacokinetic interactions with inhaled budesonide.

Hermann R, Siegmund W, Giessmann T, Westphal K, Weinbrenner A, Hauns B, Reutter F, Lahu G, Zech K, Bethke TD. Hermann R, et al. Among authors: bethke td. J Clin Pharmacol. 2007 Aug;47(8):1005-13. doi: 10.1177/0091270007300950. J Clin Pharmacol. 2007. PMID: 17660483 Clinical Trial.

8

The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitis.

Schmidt BM, Kusma M, Feuring M, Timmer WE, Neuhäuser M, Bethke T, Stuck BA, Hörmann K, Wehling M. Schmidt BM, et al. J Allergy Clin Immunol. 2001 Oct;108(4):530-6. doi: 10.1067/mai.2001.118596. J Allergy Clin Immunol. 2001. PMID: 11590377 Clinical Trial.

9

Absence of pharmacokinetic interaction between roflumilast and digoxin in healthy adults.

Eckermann G, Lahu G, Nassr N, Bethke TD. Eckermann G, et al. Among authors: bethke td. J Clin Pharmacol. 2012 Feb;52(2):251-7. doi: 10.1177/0091270010389467. J Clin Pharmacol. 2012. PMID: 21257799 Clinical Trial.

10

Lack of pharmacokinetic and pharmacodynamic interactions of roflumilast with (R, S)-warfarin in healthy adult subjects.

McCracken N, Lahu G, Bethke TD. McCracken N, et al. Among authors: bethke td. Int J Clin Pharmacol Ther. 2011 Jun;49(6):388-96. doi: 10.5414/cp201523. Int J Clin Pharmacol Ther. 2011. PMID: 21612746 Clinical Trial.

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