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NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, Su L, Pratt D, Bu CH, Hildebrand S, Lyon S, Scott L, Quan J, Sun Q, Russell J, Arnett S, Jurek P, Chen D, Kravchenko VV, Mathison JC, Moresco EM, Monson NL, Ulevitch RJ, Beutler B. Shi H, et al. Among authors: beutler b. Nat Immunol. 2016 Mar;17(3):250-8. doi: 10.1038/ni.3333. Epub 2015 Dec 7. Nat Immunol. 2016. PMID: 26642356 Free PMC article.
CD14 is required for MyD88-independent LPS signaling.
Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B. Jiang Z, et al. Among authors: beutler b. Nat Immunol. 2005 Jun;6(6):565-70. doi: 10.1038/ni1207. Epub 2005 May 15. Nat Immunol. 2005. PMID: 15895089
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9.
Tabeta K, Hoebe K, Janssen EM, Du X, Georgel P, Crozat K, Mudd S, Mann N, Sovath S, Goode J, Shamel L, Herskovits AA, Portnoy DA, Cooke M, Tarantino LM, Wiltshire T, Steinberg BE, Grinstein S, Beutler B. Tabeta K, et al. Among authors: beutler b. Nat Immunol. 2006 Feb;7(2):156-64. doi: 10.1038/ni1297. Epub 2006 Jan 15. Nat Immunol. 2006. PMID: 16415873
Akirins versus infection.
Beutler B, Moresco EM. Beutler B, et al. Nat Immunol. 2008 Jan;9(1):7-9. doi: 10.1038/ni0108-7. Nat Immunol. 2008. PMID: 18087247 No abstract available.
The serine protease TMPRSS6 is required to sense iron deficiency.
Du X, She E, Gelbart T, Truksa J, Lee P, Xia Y, Khovananth K, Mudd S, Mann N, Moresco EM, Beutler E, Beutler B. Du X, et al. Among authors: beutler e, beutler b. Science. 2008 May 23;320(5879):1088-92. doi: 10.1126/science.1157121. Epub 2008 May 1. Science. 2008. PMID: 18451267 Free PMC article.
514 results