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iRhom2 is required for the secretion of mouse TNFα.
Siggs OM, Xiao N, Wang Y, Shi H, Tomisato W, Li X, Xia Y, Beutler B. Siggs OM, et al. Among authors: beutler b. Blood. 2012 Jun 14;119(24):5769-71. doi: 10.1182/blood-2012-03-417949. Epub 2012 May 1. Blood. 2012. PMID: 22550345 Free PMC article.
ENU-induced phenovariance in mice: inferences from 587 mutations.
Arnold CN, Barnes MJ, Berger M, Blasius AL, Brandl K, Croker B, Crozat K, Du X, Eidenschenk C, Georgel P, Hoebe K, Huang H, Jiang Z, Krebs P, La Vine D, Li X, Lyon S, Moresco EM, Murray AR, Popkin DL, Rutschmann S, Siggs OM, Smart NG, Sun L, Tabeta K, Webster V, Tomisato W, Won S, Xia Y, Xiao N, Beutler B. Arnold CN, et al. Among authors: beutler b. BMC Res Notes. 2012 Oct 24;5:577. doi: 10.1186/1756-0500-5-577. BMC Res Notes. 2012. PMID: 23095377 Free PMC article.
Real-time resolution of point mutations that cause phenovariance in mice.
Wang T, Zhan X, Bu CH, Lyon S, Pratt D, Hildebrand S, Choi JH, Zhang Z, Zeng M, Wang KW, Turer E, Chen Z, Zhang D, Yue T, Wang Y, Shi H, Wang J, Sun L, SoRelle J, McAlpine W, Hutchins N, Zhan X, Fina M, Gobert R, Quan J, Kreutzer M, Arnett S, Hawkins K, Leach A, Tate C, Daniel C, Reyna C, Prince L, Davis S, Purrington J, Bearden R, Weatherly J, White D, Russell J, Sun Q, Tang M, Li X, Scott L, Moresco EM, McInerney GM, Karlsson Hedestam GB, Xie Y, Beutler B. Wang T, et al. Among authors: beutler b. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):E440-9. doi: 10.1073/pnas.1423216112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605905 Free PMC article.
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component.
Shi H, Wang Y, Li X, Zhan X, Tang M, Fina M, Su L, Pratt D, Bu CH, Hildebrand S, Lyon S, Scott L, Quan J, Sun Q, Russell J, Arnett S, Jurek P, Chen D, Kravchenko VV, Mathison JC, Moresco EM, Monson NL, Ulevitch RJ, Beutler B. Shi H, et al. Among authors: beutler b. Nat Immunol. 2016 Mar;17(3):250-8. doi: 10.1038/ni.3333. Epub 2015 Dec 7. Nat Immunol. 2016. PMID: 26642356 Free PMC article.
TLR4/MD-2 activation by a synthetic agonist with no similarity to LPS.
Wang Y, Su L, Morin MD, Jones BT, Whitby LR, Surakattula MM, Huang H, Shi H, Choi JH, Wang KW, Moresco EM, Berger M, Zhan X, Zhang H, Boger DL, Beutler B. Wang Y, et al. Among authors: beutler b. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E884-93. doi: 10.1073/pnas.1525639113. Epub 2016 Feb 1. Proc Natl Acad Sci U S A. 2016. PMID: 26831104 Free PMC article.
K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria.
Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Ćiković T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B, Kuster B, Ruland J, Schneider S, Perocchi F, Groß O. Groß CJ, et al. Among authors: beutler b. Immunity. 2016 Oct 18;45(4):761-773. doi: 10.1016/j.immuni.2016.08.010. Epub 2016 Sep 27. Immunity. 2016. PMID: 27692612 Free article.
Creatine maintains intestinal homeostasis and protects against colitis.
Turer E, McAlpine W, Wang KW, Lu T, Li X, Tang M, Zhan X, Wang T, Zhan X, Bu CH, Murray AR, Beutler B. Turer E, et al. Among authors: beutler b. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1273-E1281. doi: 10.1073/pnas.1621400114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137860 Free PMC article.
IgD class switching is initiated by microbiota and limited to mucosa-associated lymphoid tissue in mice.
Choi JH, Wang KW, Zhang D, Zhan X, Wang T, Bu CH, Behrendt CL, Zeng M, Wang Y, Misawa T, Li X, Tang M, Zhan X, Scott L, Hildebrand S, Murray AR, Moresco EM, Hooper LV, Beutler B. Choi JH, et al. Among authors: beutler b. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1196-E1204. doi: 10.1073/pnas.1621258114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137874 Free PMC article.
Skin-specific regulation of SREBP processing and lipid biosynthesis by glycerol kinase 5.
Zhang D, Tomisato W, Su L, Sun L, Choi JH, Zhang Z, Wang KW, Zhan X, Choi M, Li X, Tang M, Castro-Perez JM, Hildebrand S, Murray AR, Moresco EMY, Beutler B. Zhang D, et al. Among authors: beutler b. Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5197-E5206. doi: 10.1073/pnas.1705312114. Epub 2017 Jun 12. Proc Natl Acad Sci U S A. 2017. PMID: 28607088 Free PMC article.
513 results