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The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial.
Colazingari S, Treglia M, Najjar R, Bevilacqua A. Colazingari S, et al. Among authors: bevilacqua a. Arch Gynecol Obstet. 2013 Dec;288(6):1405-11. doi: 10.1007/s00404-013-2855-3. Epub 2013 May 25. Arch Gynecol Obstet. 2013. PMID: 23708322 Clinical Trial.
METHODS: Polycystic ovary syndrome (PCOS) women undergoing IVF-ET were treated with myo-inositol combined with D-chiro-inositol in the physiological ratio (1.1 g myo-inositol plus 27.6 mg of D-chiro-inositol; INOFOLIC combi Lo.Li.pharma) or D-chiro-inositol alone (500 mg; Interqu …
METHODS: Polycystic ovary syndrome (PCOS) women undergoing IVF-ET were treated with myo-inositol combined with D-chiro-inositol in the physi …
Improvement of mouse embryo quality by myo-inositol supplementation of IVF media.
Colazingari S, Fiorenza MT, Carlomagno G, Najjar R, Bevilacqua A. Colazingari S, et al. Among authors: bevilacqua a. J Assist Reprod Genet. 2014 Apr;31(4):463-9. doi: 10.1007/s10815-014-0188-1. Epub 2014 Feb 14. J Assist Reprod Genet. 2014. PMID: 24526355 Free PMC article.
OBJECTIVE: Myo-inositol (myoIns) has a positive role in mammalian development and human reproduction. Since experiments on farming species suggest a similar role in preimplantation development, we evaluated the hypothesis that the inclusion of myoIns in human embryo …
OBJECTIVE: Myo-inositol (myoIns) has a positive role in mammalian development and human reproduction. Since experiments on farming sp …
Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology--assisted reproduction technology.
Bevilacqua A, Carlomagno G, Gerli S, Montanino Oliva M, Devroey P, Lanzone A, Soulange C, Facchinetti F, Carlo Di Renzo G, Bizzarri M, Hod M, Cavalli P, D'Anna R, Benvenga S, Chiu TT, Kamenov ZA. Bevilacqua A, et al. Gynecol Endocrinol. 2015 Jun;31(6):441-6. doi: 10.3109/09513590.2015.1006616. Epub 2015 Jun 2. Gynecol Endocrinol. 2015. PMID: 26036719 Review.
A substantial body of research on mammalian gametogenesis and human reproduction has recently investigated the effect of myo-inositol (MyoIns) on oocyte and sperm cell quality, due to its possible application to medically assisted reproduction. With a growing number
A substantial body of research on mammalian gametogenesis and human reproduction has recently investigated the effect of myo-inositol
Results from the International Consensus Conference on Myo-inositol and d-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS.
Facchinetti F, Bizzarri M, Benvenga S, D'Anna R, Lanzone A, Soulage C, Di Renzo GC, Hod M, Cavalli P, Chiu TT, Kamenov ZA, Bevilacqua A, Carlomagno G, Gerli S, Oliva MM, Devroey P. Facchinetti F, et al. Among authors: bevilacqua a. Eur J Obstet Gynecol Reprod Biol. 2015 Dec;195:72-6. doi: 10.1016/j.ejogrb.2015.09.024. Epub 2015 Oct 3. Eur J Obstet Gynecol Reprod Biol. 2015. PMID: 26479434
The treatment of PCOS women as well as the prevention of GDM seem those clinical conditions which take more advantages from MI supplementation, when used at a dose of 2g twice/day. ...However, the existence of tissue-specific ratios, namely in the ovary, has prompted resea …
The treatment of PCOS women as well as the prevention of GDM seem those clinical conditions which take more advantages from MI supplementati …
Physiological role and clinical utility of inositols in polycystic ovary syndrome.
Bevilacqua A, Bizzarri M. Bevilacqua A, et al. Best Pract Res Clin Obstet Gynaecol. 2016 Nov;37:129-139. doi: 10.1016/j.bpobgyn.2016.03.007. Epub 2016 Apr 1. Best Pract Res Clin Obstet Gynaecol. 2016. PMID: 27117028 Review.
However, both Ins isomers can be positively associated in the management of PCOS patients in a ratio corresponding to their physiological plasma ratio (40:1). This appears to exert a synergistic effect according to a multi-targeted design. In this respect, ne …
However, both Ins isomers can be positively associated in the management of PCOS patients in a ratio corresponding to their physiolog …
Does myo-inositol effect on PCOS follicles involve cytoskeleton regulation?
Bizzarri M, Cucina A, Dinicola S, Harrath AH, Alwasel SH, Unfer V, Bevilacqua A. Bizzarri M, et al. Among authors: bevilacqua a. Med Hypotheses. 2016 Jun;91:1-5. doi: 10.1016/j.mehy.2016.03.014. Epub 2016 Apr 4. Med Hypotheses. 2016. PMID: 27142131
A more compelling understanding of the mechanisms of action of inositol (and its derivatives) would greatly improve its therapeutic utilization, by conferring to current treatments a well-grounded scientific rationale....
A more compelling understanding of the mechanisms of action of inositol (and its derivatives) would greatly improve its therapeutic u
Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease.
Bizzarri M, Fuso A, Dinicola S, Cucina A, Bevilacqua A. Bizzarri M, et al. Among authors: bevilacqua a. Expert Opin Drug Metab Toxicol. 2016 Oct;12(10):1181-96. doi: 10.1080/17425255.2016.1206887. Epub 2016 Jul 14. Expert Opin Drug Metab Toxicol. 2016. PMID: 27351907 Review.
INTRODUCTION: Inositol and its derivatives comprise a huge field of biology. Myo-inositol is not only a prominent component of membrane-incorporated phosphatidylinositol, but participates in its free form, with its isomers or its phosphate derivatives, to a m …
INTRODUCTION: Inositol and its derivatives comprise a huge field of biology. Myo-inositol is not only a prominent component of …
Myo-Inositol Safety in Pregnancy: From Preimplantation Development to Newborn Animals.
Kuşcu N, Bizzarri M, Bevilacqua A. Kuşcu N, et al. Among authors: bevilacqua a. Int J Endocrinol. 2016;2016:2413857. doi: 10.1155/2016/2413857. Epub 2016 Sep 6. Int J Endocrinol. 2016. PMID: 27698667 Free PMC article.
Myo-inositol (myo-Ins) has a physiological role in mammalian gametogenesis and embryonic development and a positive clinical impact on human medically assisted reproduction. ...These data further identify myo-Ins as a possibly important supplement for human p …
Myo-inositol (myo-Ins) has a physiological role in mammalian gametogenesis and embryonic development and a positive clinical i …
Broad Spectrum Anticancer Activity of Myo-Inositol and Inositol Hexakisphosphate.
Bizzarri M, Dinicola S, Bevilacqua A, Cucina A. Bizzarri M, et al. Among authors: bevilacqua a. Int J Endocrinol. 2016;2016:5616807. doi: 10.1155/2016/5616807. Epub 2016 Oct 4. Int J Endocrinol. 2016. PMID: 27795708 Free PMC article. Review.
Inositols (myo-inositol and inositol hexakisphosphate) exert a wide range of critical activities in both physiological and pathological settings. Deregulated inositol metabolism has been recorded in a number of diseases, including cancer, where inositol modulates di …
Inositols (myo-inositol and inositol hexakisphosphate) exert a wide range of critical activities in both physiological and pathologic …
Myo-inositol and D-chiro-inositol (40:1) reverse histological and functional features of polycystic ovary syndrome in a mouse model.
Bevilacqua A, Dragotto J, Giuliani A, Bizzarri M. Bevilacqua A, et al. J Cell Physiol. 2019 Jun;234(6):9387-9398. doi: 10.1002/jcp.27623. Epub 2018 Oct 14. J Cell Physiol. 2019. PMID: 30317628
When mice were returned to a normal light-dark regimen for 10 days, a slight, spontaneous improvement occurred, whereas a quick and almost complete recovery from PCOS signs and symptoms was obtained by treating animals with a daily supplementation of 4 …
When mice were returned to a normal light-dark regimen for 10 days, a slight, spontaneous improvement occurred, whereas a
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