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Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation.
Schulze-Osthoff K, Bakker AC, Vanhaesebroeck B, Beyaert R, Jacob WA, Fiers W. Schulze-Osthoff K, et al. Among authors: beyaert r. J Biol Chem. 1992 Mar 15;267(8):5317-23. J Biol Chem. 1992. PMID: 1312087
Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: possible role in the triggering and exacerbation of psoriasis by lithium treatment.
Beyaert R, Schulze-Osthoff K, Van Roy F, Fiers W. Beyaert R, et al. Eur J Immunol. 1992 Aug;22(8):2181-4. doi: 10.1002/eji.1830220835. Eur J Immunol. 1992. PMID: 1322305
Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se.
Suffys P, Beyaert R, De Valck D, Vanhaesebroeck B, Van Roy F, Fiers W. Suffys P, et al. Among authors: beyaert r. Eur J Biochem. 1991 Jan 30;195(2):465-75. doi: 10.1111/j.1432-1033.1991.tb15727.x. Eur J Biochem. 1991. PMID: 1847684
Two discrete types of tumor necrosis factor-resistant cells derived from the same cell line.
Vanhaesebroeck B, Van Bladel S, Lenaerts A, Suffys P, Beyaert R, Lucas R, Van Roy F, Fiers W. Vanhaesebroeck B, et al. Among authors: beyaert r. Cancer Res. 1991 May 1;51(9):2469-77. Cancer Res. 1991. PMID: 1849793
Tumour necrosis factor: mechanism of action at the molecular, cellular and in vivo level.
Fiers W, Beyaert R, Brouckaert P, Everaerdt B, Grooten J, Lenaerts A, Libert C, Suffys P, Takahashi N, Tavernier J, et al. Fiers W, et al. Among authors: beyaert r. Scand J Clin Lab Invest Suppl. 1990;202:159. Scand J Clin Lab Invest Suppl. 1990. PMID: 2075434 No abstract available.
Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter.
Vanhaesebroeck B, Cragoe EJ Jr, Pouysségur J, Beyaert R, Van Roy F, Fiers W. Vanhaesebroeck B, et al. Among authors: beyaert r. FEBS Lett. 1990 Feb 26;261(2):319-22. doi: 10.1016/0014-5793(90)80581-3. FEBS Lett. 1990. PMID: 2155826
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