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The cytotoxic activity of Aplidin in chronic lymphocytic leukemia (CLL) is mediated by a direct effect on leukemic cells and an indirect effect on monocyte-derived cells.
Morande PE, Zanetti SR, Borge M, Nannini P, Jancic C, Bezares RF, Bitsmans A, González M, Rodríguez AL, Galmarini CM, Gamberale R, Giordano M. Morande PE, et al. Among authors: bezares rf. Invest New Drugs. 2012 Oct;30(5):1830-40. doi: 10.1007/s10637-011-9740-3. Epub 2011 Sep 2. Invest New Drugs. 2012. PMID: 21887502
CCR4 expression in a case of cutaneous Richter's transformation of chronic lymphocytic leukemia (CLL) to diffuse large B-cell lymphoma (DLBCL) and in CLL patients with no skin manifestations.
Nannini PR, Borge M, Mikolaitis VC, Abreu C, Morande PE, Zanetti SR, Oppezzo P, Palacios F, Ledesma I, Bezares RF, Giordano M, Gamberale R. Nannini PR, et al. Among authors: bezares rf. Eur J Haematol. 2011 Jul;87(1):80-6. doi: 10.1111/j.1600-0609.2011.01613.x. Eur J Haematol. 2011. PMID: 21443542
The expression of sphingosine-1 phosphate receptor-1 in chronic lymphocytic leukemia cells is impaired by tumor microenvironmental signals and enhanced by piceatannol and R406.
Borge M, Remes Lenicov F, Nannini PR, de los Ríos Alicandú MM, Podaza E, Ceballos A, Fernández Grecco H, Cabrejo M, Bezares RF, Morande PE, Oppezzo P, Giordano M, Gamberale R. Borge M, et al. Among authors: bezares rf. J Immunol. 2014 Sep 15;193(6):3165-74. doi: 10.4049/jimmunol.1400547. Epub 2014 Aug 15. J Immunol. 2014. PMID: 25127862
54 results