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Human Apurinic/Apyrimidinic Endonuclease (APE1) Is Acetylated at DNA Damage Sites in Chromatin, and Acetylation Modulates Its DNA Repair Activity.
Roychoudhury S, Nath S, Song H, Hegde ML, Bellot LJ, Mantha AK, Sengupta S, Ray S, Natarajan A, Bhakat KK. Roychoudhury S, et al. Among authors: Bhakat KK. Mol Cell Biol. 2017 Mar 1;37(6):e00401-16. doi: 10.1128/MCB.00401-16. Print 2017 Mar 15. Mol Cell Biol. 2017. PMID: 27994014 Free PMC article.
Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells.
Lirussi L, Antoniali G, Vascotto C, D'Ambrosio C, Poletto M, Romanello M, Marasco D, Leone M, Quadrifoglio F, Bhakat KK, Scaloni A, Tell G. Lirussi L, et al. Among authors: Bhakat KK. Mol Biol Cell. 2012 Oct;23(20):4079-96. doi: 10.1091/mbc.E12-04-0299. Epub 2012 Aug 23. Mol Biol Cell. 2012. PMID: 22918947 Free PMC article.
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