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Target identification for small-molecule discovery in the FOXO3a tumor-suppressor pathway using a biodiverse peptide library.
Emery A, Hardwick BS, Crooks AT, Milech N, Watt PM, Mithra C, Kumar V, Giridharan S, Sadasivam G, Mathivanan S, Sudhakar S, Bairy S, Bharatham K, Hurakadli MA, Prasad TK, Kamariah N, Muellner M, Coelho M, Torrance CJ, McKenzie GJ, Venkitaraman AR. Emery A, et al. Among authors: bharatham k. Cell Chem Biol. 2021 Nov 18;28(11):1602-1615.e9. doi: 10.1016/j.chembiol.2021.05.009. Epub 2021 Jun 9. Cell Chem Biol. 2021. PMID: 34111400 Free PMC article.
Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling.
Periasamy J, Kurdekar V, Jasti S, Nijaguna MB, Boggaram S, Hurakadli MA, Raina D, Kurup LM, Chintha C, Manjunath K, Goyal A, Sadasivam G, Bharatham K, Padigaru M, Potluri V, Venkitaraman AR. Periasamy J, et al. Among authors: bharatham k. Cell Chem Biol. 2018 Jun 21;25(6):677-690.e12. doi: 10.1016/j.chembiol.2018.02.012. Epub 2018 Mar 29. Cell Chem Biol. 2018. PMID: 29606576 Free PMC article.
Structure-Guided Synthesis and Evaluation of Small-Molecule Inhibitors Targeting Protein-Protein Interactions of BRCA1 tBRCT Domain.
Kurdekar V, Giridharan S, Subbarao J, Nijaguna MB, Periasamy J, Boggaram S, Shivange AV, Sadasivam G, Padigaru M, Potluri V, Venkitaraman AR, Bharatham K. Kurdekar V, et al. Among authors: bharatham k. ChemMedChem. 2019 Sep 18;14(18):1620-1632. doi: 10.1002/cmdc.201900300. Epub 2019 Sep 9. ChemMedChem. 2019. PMID: 31334915
Structure of a 14-3-3ε:FOXO3apS253 Phosphopeptide Complex Reveals 14-3-3 Isoform-Specific Binding of Forkhead Box Class O Transcription Factor (FOXO) Phosphoproteins.
Mathivanan S, Chunchagatta Lakshman PK, Singh M, Giridharan S, Sathish K, Hurakadli MA, Bharatham K, Kamariah N. Mathivanan S, et al. Among authors: bharatham k. ACS Omega. 2022 Jul 5;7(28):24344-24352. doi: 10.1021/acsomega.2c01700. eCollection 2022 Jul 19. ACS Omega. 2022. PMID: 35874228 Free PMC article.
Metabolic activation of CaMKII by coenzyme A.
McCoy F, Darbandi R, Lee HC, Bharatham K, Moldoveanu T, Grace CR, Dodd K, Lin W, Chen SI, Tangallapally RP, Kurokawa M, Lee RE, Shelat AA, Chen T, Green DR, Harris RA, Lin SH, Fissore RA, Colbran RJ, Nutt LK. McCoy F, et al. Among authors: bharatham k. Mol Cell. 2013 Nov 7;52(3):325-39. doi: 10.1016/j.molcel.2013.08.043. Epub 2013 Oct 3. Mol Cell. 2013. PMID: 24095281 Free PMC article.
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