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Nuclear factor-kappa B and cancer: its role in prevention and therapy.
Bharti AC, Aggarwal BB. Bharti AC, et al. Biochem Pharmacol. 2002 Sep;64(5-6):883-8. doi: 10.1016/s0006-2952(02)01154-1. Biochem Pharmacol. 2002. PMID: 12213582 Review.
PARP cleavage and caspase activity to assess chemosensitivity.
Bharti AC, Takada Y, Aggarwal BB. Bharti AC, et al. Methods Mol Med. 2005;111:69-78. doi: 10.1385/1-59259-889-7:069. Methods Mol Med. 2005. PMID: 15911972
Curcumin (diferuloylmethane) inhibits receptor activator of NF-kappa B ligand-induced NF-kappa B activation in osteoclast precursors and suppresses osteoclastogenesis.
Bharti AC, Takada Y, Aggarwal BB. Bharti AC, et al. J Immunol. 2004 May 15;172(10):5940-7. doi: 10.4049/jimmunol.172.10.5940. J Immunol. 2004. PMID: 15128775
Nuclear factor-kappaB and STAT3 are constitutively active in CD138+ cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis.
Bharti AC, Shishodia S, Reuben JM, Weber D, Alexanian R, Raj-Vadhan S, Estrov Z, Talpaz M, Aggarwal BB. Bharti AC, et al. Blood. 2004 Apr 15;103(8):3175-84. doi: 10.1182/blood-2003-06-2151. Epub 2003 Dec 18. Blood. 2004. PMID: 15070700
Evidence that receptor activator of nuclear factor (NF)-kappaB ligand can suppress cell proliferation and induce apoptosis through activation of a NF-kappaB-independent and TRAF6-dependent mechanism.
Bharti AC, Takada Y, Shishodia S, Aggarwal BB. Bharti AC, et al. J Biol Chem. 2004 Feb 13;279(7):6065-76. doi: 10.1074/jbc.M308062200. Epub 2003 Nov 25. J Biol Chem. 2004. PMID: 14645259
The role of TNF and its family members in inflammation and cancer: lessons from gene deletion.
Aggarwal BB, Shishodia S, Ashikawa K, Bharti AC. Aggarwal BB, et al. Among authors: bharti ac. Curr Drug Targets Inflamm Allergy. 2002 Dec;1(4):327-41. doi: 10.2174/1568010023344571. Curr Drug Targets Inflamm Allergy. 2002. PMID: 14561180 Review.
Anticancer potential of curcumin: preclinical and clinical studies.
Aggarwal BB, Kumar A, Bharti AC. Aggarwal BB, et al. Among authors: bharti ac. Anticancer Res. 2003 Jan-Feb;23(1A):363-98. Anticancer Res. 2003. PMID: 12680238 Review.
Chemopreventive agents induce suppression of nuclear factor-kappaB leading to chemosensitization.
Bharti AC, Aggarwal BB. Bharti AC, et al. Ann N Y Acad Sci. 2002 Nov;973:392-5. doi: 10.1111/j.1749-6632.2002.tb04671.x. Ann N Y Acad Sci. 2002. PMID: 12485899
Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.
Ashikawa K, Majumdar S, Banerjee S, Bharti AC, Shishodia S, Aggarwal BB. Ashikawa K, et al. Among authors: bharti ac. J Immunol. 2002 Dec 1;169(11):6490-7. doi: 10.4049/jimmunol.169.11.6490. J Immunol. 2002. PMID: 12444159
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.
Bharti AC, Donato N, Singh S, Aggarwal BB. Bharti AC, et al. Blood. 2003 Feb 1;101(3):1053-62. doi: 10.1182/blood-2002-05-1320. Epub 2002 Sep 5. Blood. 2003. PMID: 12393461
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