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PGC-1alpha Thr394Thr and Gly482Ser variants are significantly associated with T2DM in two North Indian populations: a replicate case-control study.
Bhat A, Koul A, Rai E, Sharma S, Dhar MK, Bamezai RN. Bhat A, et al. Hum Genet. 2007 Jun;121(5):609-14. doi: 10.1007/s00439-007-0352-0. Epub 2007 Mar 28. Hum Genet. 2007. PMID: 17390150
Logistic regression analysis for Thr394Thr susceptible genotypes together (rs2970847 G/A and A/A) conferred a 1.89-(95%CI 1.25-2.85) fold higher risk for T2DM in Group 1 and 1.81-(95%CI 1.19-2.78) fold risk in Group 2. The susceptible, Ser482 (rs819267 …
Logistic regression analysis for Thr394Thr susceptible genotypes together (rs2970847 G/A and A/A) conferred a 1. …
The Indian origin of paternal haplogroup R1a1* substantiates the autochthonous origin of Brahmins and the caste system.
Sharma S, Rai E, Sharma P, Jena M, Singh S, Darvishi K, Bhat AK, Bhanwer AJ, Tiwari PK, Bamezai RN. Sharma S, et al. J Hum Genet. 2009 Jan;54(1):47-55. doi: 10.1038/jhg.2008.2. Epub 2009 Jan 9. J Hum Genet. 2009. PMID: 19158816
A peculiar observation of the highest frequency (up to 72.22%) of Y-haplogroup R1a1* in Brahmins hinted at its presence as a founder lineage for this caste group. ...However, it is important to discover novel Y-chromosomal binary marker(s) for a higher resolu
A peculiar observation of the highest frequency (up to 72.22%) of Y-haplogroup R1a1* in Brahmins hinted at its presence as a f
Mitochondrial DNA G10398A polymorphism imparts maternal Haplogroup N a risk for breast and esophageal cancer.
Darvishi K, Sharma S, Bhat AK, Rai E, Bamezai RN. Darvishi K, et al. Cancer Lett. 2007 May 8;249(2):249-55. doi: 10.1016/j.canlet.2006.09.005. Epub 2006 Nov 1. Cancer Lett. 2007. PMID: 17081685
The role of mitochondria, however, in cancer development has been in question recently [A. Salas, Y.G. Yao, V. Macaulay, A. Vega, A. ...It is further apparent from the study that such a mtDNA polymorphism background provides a higher risk for th …
The role of mitochondria, however, in cancer development has been in question recently [A. Salas, Y.G. Yao, V. Macaulay, A. Ve …
A novel subgroup Q5 of human Y-chromosomal haplogroup Q in India.
Sharma S, Rai E, Bhat AK, Bhanwer AS, Bamezai RN. Sharma S, et al. BMC Evol Biol. 2007 Nov 19;7:232. doi: 10.1186/1471-2148-7-232. BMC Evol Biol. 2007. PMID: 18021436 Free PMC article.
Recently, a novel subgroup Q4 has been identified which is defined by bi-allelic marker M346, representing HG Q (0.41%, 3/728) in Indian population. ...It was quite interesting to observe an ancestral state Q* and a novel sub-branch Q5, not reported elsewhere, in In …
Recently, a novel subgroup Q4 has been identified which is defined by bi-allelic marker M346, representing HG Q (0.41%, 3/728) in Ind …
Interaction between the UCP2-866G/A, mtDNA 10398G/A and PGC1alpha p.Thr394Thr and p.Gly482Ser polymorphisms in type 2 diabetes susceptibility in North Indian population.
Rai E, Sharma S, Koul A, Bhat AK, Bhanwer AJ, Bamezai RN. Rai E, et al. Hum Genet. 2007 Dec;122(5):535-40. doi: 10.1007/s00439-007-0421-4. Epub 2007 Aug 14. Hum Genet. 2007. PMID: 17701054
These initial observations encouraged us to look at the candidate genes in combination with -866G/A (rs659366) polymorphism in uncoupling protein 2 (UCP2) in a single study of a relatively large sample size, constituted of both the cohorts, to unravel an inte …
These initial observations encouraged us to look at the candidate genes in combination with -866G/A (rs659366) polymorphism in uncoup …
The possible role of 10398A and 16189C mtDNA variants in providing susceptibility to T2DM in two North Indian populations: a replicative study.
Bhat A, Koul A, Sharma S, Rai E, Bukhari SI, Dhar MK, Bamezai RN. Bhat A, et al. Hum Genet. 2007 Feb;120(6):821-6. doi: 10.1007/s00439-006-0272-4. Epub 2006 Oct 26. Hum Genet. 2007. PMID: 17066297
A case control study on 312 T2DM cases and ethnically matched 466 controls involving two North Indian populations, referred as cohort 1 and cohort 2 (in a replicative study), was undertaken to test such a genetic association. ...The analysis of G10398A/T16189
A case control study on 312 T2DM cases and ethnically matched 466 controls involving two North Indian populations, referred as cohort
Genetic affinity among five different population groups in India reflecting a Y-chromosome gene flow.
Saha A, Sharma S, Bhat A, Pandit A, Bamezai R. Saha A, et al. J Hum Genet. 2005;50(1):49-51. doi: 10.1007/s10038-004-0219-3. Epub 2004 Dec 21. J Hum Genet. 2005. PMID: 15611834
Analyses of the haplogroups indicated no single origin from any lineage but a result of a conglomeration of different lineages from time to time. The phylogenetic analyses indicate a high degree of population admixture and a greater genetic proximity f …
Analyses of the haplogroups indicated no single origin from any lineage but a result of a conglomeration of different lineages …
Genetic variant rs10937405 of TP63 and susceptibility to lung cancer risk in north Indian population.
Rasool Bhat GH, Bhat A, Verma S, Sethi I, Shah R, Sharma V, Minerva S, Bakshi D, Sharma B, Koul S, Abrol D, Bhat A, Kumar R. Rasool Bhat GH, et al. J Genet. 2019 Jun;98(2):59. J Genet. 2019. PMID: 31204706
Several studies including genomewide association studies (GWASs) in diverse ethnic populations have reported a significant association of genetic variant rs10937405 of TP63 with nonsmall cell lung cancer (NSCLC). ...Our data support that the rs10937405 variant is also sign …
Several studies including genomewide association studies (GWASs) in diverse ethnic populations have reported a significant associatio …
Molecular modeling on pyruvate phosphate dikinase of Entamoeba histolytica and in silico virtual screening for novel inhibitors.
Stephen P, Vijayan R, Bhat A, Subbarao N, Bamezai RN. Stephen P, et al. J Comput Aided Mol Des. 2008 Sep;22(9):647-60. doi: 10.1007/s10822-007-9130-2. Epub 2007 Aug 21. J Comput Aided Mol Des. 2008. PMID: 17710553
Virtual screening was carried out using the genetic docking algorithm GOLD and a consensus scoring function X-Score to substantiate the prediction. ...
Virtual screening was carried out using the genetic docking algorithm GOLD and a consensus scoring function X-Score to substantiate t …
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