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P2Y(12) antagonists as antiplatelet agents - Recent developments.

Bhavaraju K, Mayanglambam A, Rao AK, Kunapuli SP. Bhavaraju K, et al. Curr Opin Drug Discov Devel. 2010 Jul;13(4):497-506. Curr Opin Drug Discov Devel. 2010. PMID: 20597033 Review.

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Protein kinase C isoform ε negatively regulates ADP-induced calcium mobilization and thromboxane generation in platelets.

Bynagari-Settipalli YS, Lakhani P, Jin J, Bhavaraju K, Rico MC, Kim S, Woulfe D, Kunapuli SP. Bynagari-Settipalli YS, et al. Among authors: bhavaraju k. Arterioscler Thromb Vasc Biol. 2012 May;32(5):1211-9. doi: 10.1161/ATVBAHA.111.242388. Epub 2012 Feb 23. Arterioscler Thromb Vasc Biol. 2012. PMID: 22362759 Free PMC article.

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Antagonism of P2Y₁₂ reduces physiological thromboxane levels.

Bhavaraju K, Georgakis A, Jin J, Gartner TK, Tomiyama Y, Nurden A, Nurden P, Kunapuli SP. Bhavaraju K, et al. Platelets. 2010;21(8):604-9. doi: 10.3109/09537104.2010.511684. Platelets. 2010. PMID: 21067313 Clinical Trial.

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Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways.

Garcia A, Kim S, Bhavaraju K, Schoenwaelder SM, Kunapuli SP. Garcia A, et al. Among authors: bhavaraju k. Biochem J. 2010 Jul 15;429(2):369-77. doi: 10.1042/BJ20100166. Biochem J. 2010. PMID: 20441566

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Mechanism of activation and functional role of protein kinase Ceta in human platelets.

Bynagari YS, Nagy B Jr, Tuluc F, Bhavaraju K, Kim S, Vijayan KV, Kunapuli SP. Bynagari YS, et al. Among authors: bhavaraju k. J Biol Chem. 2009 May 15;284(20):13413-13421. doi: 10.1074/jbc.M808970200. Epub 2009 Mar 13. J Biol Chem. 2009. PMID: 19286657 Free PMC article.

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Protein kinase C[delta] differentially regulates platelet functional responses.

Chari R, Getz T, Nagy B Jr, Bhavaraju K, Mao Y, Bynagari YS, Murugappan S, Nakayama K, Kunapuli SP. Chari R, et al. Among authors: bhavaraju k. Arterioscler Thromb Vasc Biol. 2009 May;29(5):699-705. doi: 10.1161/ATVBAHA.109.184010. Epub 2009 Feb 12. Arterioscler Thromb Vasc Biol. 2009. PMID: 19213940 Free PMC article.

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Evaluation of [3-(1-methyl-1H-indol-3-yl-methylene)-2-oxo-2, 3-dihydro-1H-indole-5-sulfonamide] (OXSI-2), as a Syk-selective inhibitor in platelets.

Bhavaraju K, Kim S, Daniel JL, Kunapuli SP. Bhavaraju K, et al. Eur J Pharmacol. 2008 Feb 12;580(3):285-90. doi: 10.1016/j.ejphar.2007.11.009. Epub 2007 Nov 17. Eur J Pharmacol. 2008. PMID: 18068154 Free PMC article.

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Impaired activation of platelets lacking protein kinase C-theta isoform.

Nagy B Jr, Bhavaraju K, Getz T, Bynagari YS, Kim S, Kunapuli SP. Nagy B Jr, et al. Among authors: bhavaraju k. Blood. 2009 Mar 12;113(11):2557-67. doi: 10.1182/blood-2008-07-169268. Epub 2009 Jan 22. Blood. 2009. PMID: 19164598 Free PMC article.

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G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.

Bhavaraju K, Lakhani PR, Dorsam RT, Jin J, Hitchcock IS, Sanjay A, Kunapuli SP. Bhavaraju K, et al. PLoS One. 2011 Feb 10;6(2):e16586. doi: 10.1371/journal.pone.0016586. PLoS One. 2011. PMID: 21347357 Free PMC article.

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