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A bivalent ligand (KDAN-18) containing delta-antagonist and kappa-agonist pharmacophores bridges delta2 and kappa1 opioid receptor phenotypes.
J Med Chem. 2005 Mar 24;48(6):1713-6. doi: 10.1021/jm034234f.
J Med Chem. 2005.
PMID: 15771416
A bivalent ligand (KDN-21) reveals spinal delta and kappa opioid receptors are organized as heterodimers that give rise to delta(1) and kappa(2) phenotypes. Selective targeting of delta-kappa heterodimers.
Bhushan RG, Sharma SK, Xie Z, Daniels DJ, Portoghese PS.
Bhushan RG, et al.
J Med Chem. 2004 Jun 3;47(12):2969-72. doi: 10.1021/jm0342358.
J Med Chem. 2004.
PMID: 15163177
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Interaction of bivalent ligand KDN21 with heterodimeric delta-kappa opioid receptors in human embryonic kidney 293 cells.
Xie Z, Bhushan RG, Daniels DJ, Portoghese PS.
Xie Z, et al. Among authors: bhushan rg.
Mol Pharmacol. 2005 Oct;68(4):1079-86. doi: 10.1124/mol.105.012070. Epub 2005 Jul 8.
Mol Pharmacol. 2005.
PMID: 16006595
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Synthesis of conformationally restricted 2',3'-exo-methylene carbocyclic nucleosides built on a bicyclo[3.1.0]hexane template.
Bhushan RG, Vince R.
Bhushan RG, et al.
Bioorg Med Chem. 2002 Jul;10(7):2325-33. doi: 10.1016/s0968-0896(02)00063-9.
Bioorg Med Chem. 2002.
PMID: 11983530
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