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An Atlas of β-Glucuronidases in the Human Intestinal Microbiome.
Pollet RM, D'Agostino EH, Walton WG, Xu Y, Little MS, Biernat KA, Pellock SJ, Patterson LM, Creekmore BC, Isenberg HN, Bahethi RR, Bhatt AP, Liu J, Gharaibeh RZ, Redinbo MR. Pollet RM, et al. Among authors: biernat ka. Structure. 2017 Jul 5;25(7):967-977.e5. doi: 10.1016/j.str.2017.05.003. Epub 2017 Jun 1. Structure. 2017. PMID: 28578872 Free PMC article.
Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity.
Wallace BD, Roberts AB, Pollet RM, Ingle JD, Biernat KA, Pellock SJ, Venkatesh MK, Guthrie L, O'Neal SK, Robinson SJ, Dollinger M, Figueroa E, McShane SR, Cohen RD, Jin J, Frye SV, Zamboni WC, Pepe-Ranney C, Mani S, Kelly L, Redinbo MR. Wallace BD, et al. Among authors: biernat ka. Chem Biol. 2015 Sep 17;22(9):1238-49. doi: 10.1016/j.chembiol.2015.08.005. Epub 2015 Sep 10. Chem Biol. 2015. PMID: 26364932 Free PMC article.
Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy.
Bhatt AP, Pellock SJ, Biernat KA, Walton WG, Wallace BD, Creekmore BC, Letertre MM, Swann JR, Wilson ID, Roques JR, Darr DB, Bailey ST, Montgomery SA, Roach JM, Azcarate-Peril MA, Sartor RB, Gharaibeh RZ, Bultman SJ, Redinbo MR. Bhatt AP, et al. Among authors: biernat ka. Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7374-7381. doi: 10.1073/pnas.1918095117. Epub 2020 Mar 13. Proc Natl Acad Sci U S A. 2020. PMID: 32170007 Free PMC article.
Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception.
Pellock SJ, Creekmore BC, Walton WG, Mehta N, Biernat KA, Cesmat AP, Ariyarathna Y, Dunn ZD, Li B, Jin J, James LI, Redinbo MR. Pellock SJ, et al. Among authors: biernat ka. ACS Cent Sci. 2018 Jul 25;4(7):868-879. doi: 10.1021/acscentsci.8b00239. Epub 2018 Jul 12. ACS Cent Sci. 2018. PMID: 30062115 Free PMC article.
Microbial Unmasking of Plant Glycosides.
Biernat KA, Li B, Redinbo MR. Biernat KA, et al. mBio. 2018 Jan 30;9(1):e02433-17. doi: 10.1128/mBio.02433-17. mBio. 2018. PMID: 29382739 Free PMC article.
16 results