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CD45 tyrosine phosphatase-activated p59fyn couples the T cell antigen receptor to pathways of diacylglycerol production, protein kinase C activation and calcium influx.
Shiroo M, Goff L, Biffen M, Shivnan E, Alexander D. Shiroo M, et al. Among authors: biffen m. EMBO J. 1992 Dec;11(13):4887-97. EMBO J. 1992. PMID: 1464315 Free PMC article.
The CD45 tyrosine phosphatase regulates specific pools of antigen receptor-associated p59fyn and CD4-associated p56lck tyrosine in human T-cells.
Biffen M, McMichael-Phillips D, Larson T, Venkitaraman A, Alexander D. Biffen M, et al. EMBO J. 1994 Apr 15;13(8):1920-9. EMBO J. 1994. PMID: 8168490 Free PMC article.
Does co-aggregation of the CD45 and CD3 antigens inhibit T cell antigen receptor complex-mediated activation of phospholipase C and protein kinase C?
Shivnan E, Biffen M, Shiroo M, Pratt E, Glennie M, Alexander D. Shivnan E, et al. Among authors: biffen m. Eur J Immunol. 1992 Apr;22(4):1055-62. doi: 10.1002/eji.1830220427. Eur J Immunol. 1992. PMID: 1532359
The role of CD45 in T-cell activation--resolving the paradoxes?
Alexander D, Shiroo M, Robinson A, Biffen M, Shivnan E. Alexander D, et al. Among authors: biffen m. Immunol Today. 1992 Dec;13(12):477-81. doi: 10.1016/0167-5699(92)90021-X. Immunol Today. 1992. PMID: 1463579 Review.
G-proteins are not directly involved in the CD3-antigen-mediated production of inositol phosphates in HPB-ALL T-leukaemia cells expressing phospholipase C isoforms gamma 1 and beta 3.
Biffen M, Shiroo M, Alexander DR. Biffen M, et al. Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):387-94. doi: 10.1042/bj2890387. Biochem J. 1993. PMID: 8424784 Free PMC article.
Selective coupling of the T cell antigen receptor to phosphoinositide-derived diacylglycerol production in HPB-ALL T cells correlates with CD45-regulated p59fyn activity.
Biffen M, Shiroo M, Alexander DR. Biffen M, et al. Eur J Immunol. 1993 Nov;23(11):2980-7. doi: 10.1002/eji.1830231138. Eur J Immunol. 1993. PMID: 8223875
Mobilization of intracellular Ca2+ by adenine nucleotides in human T-leukaemia cells: evidence for ADP-specific and P2y-purinergic receptors.
Biffen M, Alexander DR. Biffen M, et al. Biochem J. 1994 Dec 15;304 ( Pt 3)(Pt 3):769-74. doi: 10.1042/bj3040769. Biochem J. 1994. PMID: 7818479 Free PMC article.
Inhibition of PI-kinase in rat liver membranes by F-.
Biffen M, Martin BR. Biffen M, et al. Cell Signal. 1989;1(3):283-7. doi: 10.1016/0898-6568(89)90045-4. Cell Signal. 1989. PMID: 2561945
Vasopressin-stimulated Ca2+ influx in rat hepatocytes is inhibited in high-K+ medium.
Savage AL, Biffen M, Martin BR. Savage AL, et al. Among authors: biffen m. Biochem J. 1989 Jun 15;260(3):821-7. doi: 10.1042/bj2600821. Biochem J. 1989. PMID: 2548488 Free PMC article.
Reduction in the level of intracellular myo-inositol in cultured soybean (Glycine max) cells inhibits cell division.
Biffen M, Hanke DE. Biffen M, et al. Biochem J. 1990 Feb 1;265(3):809-14. doi: 10.1042/bj2650809. Biochem J. 1990. PMID: 2306214 Free PMC article.
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