Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity.
Zhao M, Ren Z, Zhao A, Tang Y, Kuang J, Li M, Chen T, Wang S, Wang J, Zhang H, Wang J, Zhang T, Zeng J, Liu X, Xie G, Liu P, Sun N, Bao T, Nie T, Lin J, Liu P, Zheng Y, Zheng X, Liu T, Jia W.
Zhao M, et al.
Cell Metab. 2024 May 7;36(5):1000-1012.e6. doi: 10.1016/j.cmet.2024.03.010. Epub 2024 Apr 5.
Cell Metab. 2024.
PMID: 38582087
Free article.
We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, and the neurotransmitter homovanillic acid (HVA) in individuals with depression and mouse depression models. Although R. intestinalis does not directly produce H …
We observed depleted gut bacterial species, including Bifidobacterium longum and Roseburia intestinalis, and the neurotransmit …