Comparative Pharmacokinetic Profiles of Three Protoberberine-type Alkaloids from Raw and Bile-processed Rhizoma coptidis in Heat Syndrome Rats.
Pharmacogn Mag. 2017.
PMID: 28216883
Free PMC article.
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Bile-processed+heat syndrome+pharmacokinetic profiles+porto berberine type alkaloids+Rhizoma coptidis
(77 results)?
Identification of bioactive compounds and potential mechanisms of scutellariae radix-coptidis rhizoma in the treatment of atherosclerosis by integrating network pharmacology and experimental validation.
Biomed Pharmacother. 2023 Sep;165:115210. doi: 10.1016/j.biopha.2023.115210. Epub 2023 Jul 25.
Biomed Pharmacother. 2023.
PMID: 37499457
Free article.
OBJECTIVE: This study aims at investigating the potential targets and functional mechanisms of Scutellariae Radix-Coptidis Rhizoma (QLYD) against atherosclerosis (AS) through network pharmacology, molecular docking, bioinformatic analysis and experimental validation. ...
OBJECTIVE: This study aims at investigating the potential targets and functional mechanisms of Scutellariae Radix-Coptidis Rhizoma (Q …
Coptidis rhizoma and berberine as anti-cancer drugs: A 10-year updates and future perspectives.
Pharmacol Res. 2025 Jun;216:107742. doi: 10.1016/j.phrs.2025.107742. Epub 2025 Apr 19.
Pharmacol Res. 2025.
PMID: 40258505
Free article.
Review.
This paper offers an exhaustive overview of the cancer-fighting characteristics of Coptidis Rhizoma and berberine, while also exploring recent developments in nanotechnology aimed at enhancing the bioavailability of berberine. ...This paper provides precious perspectives o …
This paper offers an exhaustive overview of the cancer-fighting characteristics of Coptidis Rhizoma and berberine, while also explori …
Epiberberine ameliorates ulcerative colitis by regulating bile acids hepatoenteral circulation through intestinal FXR.
Phytomedicine. 2025 Jul 25;143:156831. doi: 10.1016/j.phymed.2025.156831. Epub 2025 May 5.
Phytomedicine. 2025.
PMID: 40334429
Abnormal bile acid accumulation in the intestine further exacerbates intestinal inflammation in patients with UC. Coptidis Rhizoma has potential therapeutic activity against UC; however, its capacity to modulate bile acids in UC remains poorly explored. ...Additionally, th …
Abnormal bile acid accumulation in the intestine further exacerbates intestinal inflammation in patients with UC. Coptidis Rhizoma ha …
Comparative Pharmacokinetic Profiles of Three Protoberberine-type Alkaloids from Raw and Bile-processed Rhizoma coptidis in Heat Syndrome Rats.
Pharmacogn Mag. 2017 Jan-Mar;13(49):51-57. doi: 10.4103/0973-1296.197632.
Pharmacogn Mag. 2017.
PMID: 28216883
Free PMC article.
BACKGROUND: The Bile-processed Rhizoma coptidis (BRC), which has a colder drug property than Rhizoma coptidis (RC), is widely used for the treatment of heat syndrome. ...SUMMARY: Contents of berberine, palmatine and jatrorrhizine, in heat syndrome rats' plasma betwe …
BACKGROUND: The Bile-processed Rhizoma coptidis (BRC), which has a colder drug property than Rhizoma coptidis (RC), is widely …
Bile-processed Rhizoma Coptidis alleviates type 2 diabetes mellitus through modulating the gut microbiota and short-chain fatty acid metabolism.
Int Immunopharmacol. 2025 May 27;156:114645. doi: 10.1016/j.intimp.2025.114645. Epub 2025 Apr 19.
Int Immunopharmacol. 2025.
PMID: 40253770
BACKGROUND: Bile-Processed Rhizoma Coptidis (BPRC) is a processed products of Rhizoma Coptidis (RC) commonly used to treat type 2 diabetes mellitus (T2DM). ...
BACKGROUND: Bile-Processed Rhizoma Coptidis (BPRC) is a processed products of Rhizoma Coptidis (RC) commonly used to treat typ …
A "controlled assembly" strategy for constructing Coptidis Rhizoma self-assembled nanoparticles to ameliorate inflammatory damage in Atopic dermatitis.
Bioact Mater. 2025 Oct 22;56:234-247. doi: 10.1016/j.bioactmat.2025.10.010. eCollection 2026 Feb.
Bioact Mater. 2025.
PMID: 41211576
Free PMC article.
In this study, we propose an innovative "controlled assembly" strategy to improve the self-assembly process of decoction. Coptidis Rhizoma self-assembled nanoparticles (CR-SAN) were constructed via hydrochloric acid-assisted aqueous extraction followed by pH-driven assembl …
In this study, we propose an innovative "controlled assembly" strategy to improve the self-assembly process of decoction. Coptidis Rh …
Antihypertensive constituents in Sanoshashinto.
J Nat Med. 2020 Mar;74(2):421-433. doi: 10.1007/s11418-019-01382-9. Epub 2020 Jan 1.
J Nat Med. 2020.
PMID: 31894475
Free PMC article.
It has been reported that Sanoshashinto (SanHuangXieXinTang, ), which is composed of Rhei Rhizoma, Scutellariae Radix, and Coptidis Rhizoma, exhibits vasorelaxant effects in vitro and lowers blood pressure of patients. ...These findings suggested that Sanoshashinto has sig …
It has been reported that Sanoshashinto (SanHuangXieXinTang, ), which is composed of Rhei Rhizoma, Scutellariae Radix, and Coptidis R …
Rhizoma Coptidis polysaccharides: extraction, separation, purification, structural characteristics and bioactivities.
Int J Biol Macromol. 2025 Aug;320(Pt 1):145677. doi: 10.1016/j.ijbiomac.2025.145677. Epub 2025 Jul 1.
Int J Biol Macromol. 2025.
PMID: 40609932
Review.
Rhizoma Coptidis, a perennial herb from the Ranunculaceae family, is celebrated for its diverse medicinal properties. ...This review provides an in-depth analysis of Rhizoma Coptidis' botanical characteristics, the current understanding of RCP's chemical structure, …
Rhizoma Coptidis, a perennial herb from the Ranunculaceae family, is celebrated for its diverse medicinal properties. ...This review …
Current Advances in Coptidis Rhizoma for Gastrointestinal and Other Cancers.
Front Pharmacol. 2022 Jan 3;12:775084. doi: 10.3389/fphar.2021.775084. eCollection 2021.
Front Pharmacol. 2022.
PMID: 35046810
Free PMC article.
Review.
Gastrointestinal cancer defines a group of cancers in the digestive system, e.g., liver cancer, colorectal cancer, and gastric cancer. Coptidis Rhizoma (C. Rhizoma; Huanglian, in Chinese) is a classical Chinese medicinal botanical drug for the treatment of gastrointestinal …
Gastrointestinal cancer defines a group of cancers in the digestive system, e.g., liver cancer, colorectal cancer, and gastric cancer. Co …
Constituents, Pharmacokinetics, and Pharmacology of Gegen-Qinlian Decoction.
Front Pharmacol. 2021 May 7;12:668418. doi: 10.3389/fphar.2021.668418. eCollection 2021.
Front Pharmacol. 2021.
PMID: 34025427
Free PMC article.
Review.
It is composed of four TCMs, including Puerariae Lobatae Radix, Scutellariae Radix, Coptidis Rhizoma, and Glycyrrhizae Radix et Rhizoma Praeparata cum Melle. GQD is traditionally and clinically used to treat both the "external and internal symptoms" of diarrhea with fever. …
It is composed of four TCMs, including Puerariae Lobatae Radix, Scutellariae Radix, Coptidis Rhizoma, and Glycyrrhizae Radix et Rhizo …
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