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Properties of the retained N-terminal hydrophobic leader sequence in human serum paraoxonase/arylesterase.
Sorenson RC, Aviram M, Bisgaier CL, Billecke S, Hsu C, La Du BN. Sorenson RC, et al. Among authors: billecke s. Chem Biol Interact. 1999 May 14;119-120:243-9. doi: 10.1016/s0009-2797(99)00033-2. Chem Biol Interact. 1999. PMID: 10421458
The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase.
Billecke SS, Draganov DI, Morishima Y, Murphy PJ, Dunbar AY, Pratt WB, Osawa Y. Billecke SS, et al. J Biol Chem. 2004 Jul 16;279(29):30252-8. doi: 10.1074/jbc.M403864200. Epub 2004 May 19. J Biol Chem. 2004. PMID: 15155759
We have shown previously that nNOS expressed in Sf9 cells where endogenous heme levels are low is activated from the apo- to the holo-enzyme by addition of exogenous heme to the culture medium, and this activation is inhibited by radicicol, a specific inhibitor of hsp90 (Bille
We have shown previously that nNOS expressed in Sf9 cells where endogenous heme levels are low is activated from the apo- to the holo-enzyme …
hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90.
Billecke SS, Bender AT, Kanelakis KC, Murphy PJ, Lowe ER, Kamada Y, Pratt WB, Osawa Y. Billecke SS, et al. J Biol Chem. 2002 Jun 7;277(23):20504-9. doi: 10.1074/jbc.M201940200. Epub 2002 Mar 28. J Biol Chem. 2002. PMID: 11923316
Rabbits possess a serum paraoxonase polymorphism similar to the human Q192R.
Watson CE, Draganov DI, Billecke SS, Bisgaier CL, La Du BN. Watson CE, et al. Among authors: billecke ss. Pharmacogenetics. 2001 Mar;11(2):123-34. doi: 10.1097/00008571-200103000-00003. Pharmacogenetics. 2001. PMID: 11266077
Rabbit serum paraoxonase 3 (PON3) is a high density lipoprotein-associated lactonase and protects low density lipoprotein against oxidation.
Draganov DI, Stetson PL, Watson CE, Billecke SS, La Du BN. Draganov DI, et al. Among authors: billecke ss. J Biol Chem. 2000 Oct 27;275(43):33435-42. doi: 10.1074/jbc.M004543200. J Biol Chem. 2000. PMID: 10931838
Evidence that several conserved histidine residues are required for hydrolytic activity of human paraoxonase/arylesterase.
Doorn JA, Sorenson RC, Billecke SS, Hsu C, La Du BN. Doorn JA, et al. Among authors: billecke ss. Chem Biol Interact. 1999 May 14;119-120:235-41. doi: 10.1016/s0009-2797(99)00032-0. Chem Biol Interact. 1999. PMID: 10421457
Characterization of a soluble mouse liver enzyme capable of hydrolyzing diisopropyl phosphorofluoridate.
Billecke SS, Primo-Parmo SL, Dunlop CS, Doorn JA, La Du BN, Broomfield CA. Billecke SS, et al. Chem Biol Interact. 1999 May 14;119-120:251-6. doi: 10.1016/s0009-2797(99)00034-4. Chem Biol Interact. 1999. PMID: 10421459
Serum paraoxonase (PON1) isozymes: the quantitative analysis of isozymes affecting individual sensitivity to environmental chemicals.
La Du BN, Billecke S, Hsu C, Haley RW, Broomfield CA. La Du BN, et al. Among authors: billecke s. Drug Metab Dispos. 2001 Apr;29(4 Pt 2):566-9. Drug Metab Dispos. 2001. PMID: 11259353
Paraoxonase active site required for protection against LDL oxidation involves its free sulfhydryl group and is different from that required for its arylesterase/paraoxonase activities: selective action of human paraoxonase allozymes Q and R.
Aviram M, Billecke S, Sorenson R, Bisgaier C, Newton R, Rosenblat M, Erogul J, Hsu C, Dunlop C, La Du B. Aviram M, et al. Among authors: billecke s. Arterioscler Thromb Vasc Biol. 1998 Oct;18(10):1617-24. doi: 10.1161/01.atv.18.10.1617. Arterioscler Thromb Vasc Biol. 1998. PMID: 9763535
Human serum paraoxonase (PON 1) is inactivated by oxidized low density lipoprotein and preserved by antioxidants.
Aviram M, Rosenblat M, Billecke S, Erogul J, Sorenson R, Bisgaier CL, Newton RS, La Du B. Aviram M, et al. Among authors: billecke s. Free Radic Biol Med. 1999 Apr;26(7-8):892-904. doi: 10.1016/s0891-5849(98)00272-x. Free Radic Biol Med. 1999. PMID: 10232833
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