Bilsky EJ - Search Results

1

14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects.

Ananthan S, Saini SK, Dersch CM, Xu H, McGlinchey N, Giuvelis D, Bilsky EJ, Rothman RB. Ananthan S, et al. Among authors: bilsky ej. J Med Chem. 2012 Oct 11;55(19):8350-63. doi: 10.1021/jm300686p. Epub 2012 Sep 27. J Med Chem. 2012. PMID: 23016952 Free PMC article.

2

Design, synthesis, and characterization of 6beta-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes.

Pelotte AL, Smith RM, Ayestas M, Dersch CM, Bilsky EJ, Rothman RB, Deveau AM. Pelotte AL, et al. Among authors: bilsky ej. Bioorg Med Chem Lett. 2009 May 15;19(10):2811-4. doi: 10.1016/j.bmcl.2009.03.095. Epub 2009 Mar 26. Bioorg Med Chem Lett. 2009. PMID: 19364645

3

Synthesis and Structure-Activity Relationships of 5'-Aryl-14-alkoxypyridomorphinans: Identification of a μ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects.

Vekariya RH, Lei W, Ray A, Saini SK, Zhang S, Molnar G, Barlow D, Karlage KL, Bilsky EJ, Houseknecht KL, Largent-Milnes TM, Streicher JM, Ananthan S. Vekariya RH, et al. Among authors: bilsky ej. J Med Chem. 2020 Jul 23;63(14):7663-7694. doi: 10.1021/acs.jmedchem.0c00503. Epub 2020 Jun 30. J Med Chem. 2020. PMID: 32530286 Free PMC article.

4

Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone].

Ananthan S, Khare NK, Saini SK, Seitz LE, Bartlett JL, Davis P, Dersch CM, Porreca F, Rothman RB, Bilsky EJ. Ananthan S, et al. Among authors: bilsky ej. J Med Chem. 2004 Mar 11;47(6):1400-12. doi: 10.1021/jm030311v. J Med Chem. 2004. PMID: 14998329

5

Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans.

Ananthan S, Kezar HS 3rd, Carter RL, Saini SK, Rice KC, Wells JL, Davis P, Xu H, Dersch CM, Bilsky EJ, Porreca F, Rothman RB. Ananthan S, et al. Among authors: bilsky ej. J Med Chem. 1999 Sep 9;42(18):3527-38. doi: 10.1021/jm990039i. J Med Chem. 1999. PMID: 10479286

6

Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series.

Hiebel AC, Lee YS, Bilsky E, Giuvelis D, Deschamps JR, Parrish DA, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Partilla JS, Rothman RB, Cheng K, Jacobson AE, Rice KC. Hiebel AC, et al. J Med Chem. 2007 Aug 9;50(16):3765-76. doi: 10.1021/jm061325e. Epub 2007 Jul 11. J Med Chem. 2007. PMID: 17625813

7

Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists.

Cheng K, Kim IJ, Lee MJ, Adah SA, Raymond TJ, Bilsky EJ, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Cheng K, et al. Among authors: bilsky ej. Org Biomol Chem. 2007 Apr 21;5(8):1177-1190. doi: 10.1039/b618875c. Epub 2007 Mar 1. Org Biomol Chem. 2007. PMID: 17406716

8

In vitro and in vivo assessment of mu opioid receptor constitutive activity.

Bilsky EJ, Giuvelis D, Osborn MD, Dersch CM, Xu H, Rothman RB. Bilsky EJ, et al. Methods Enzymol. 2010;484:413-43. doi: 10.1016/B978-0-12-381298-8.00021-6. Methods Enzymol. 2010. PMID: 21036244

9

Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin?

Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R. Li Y, et al. Among authors: bilsky ej. J Med Chem. 2014 Mar 27;57(6):2237-46. doi: 10.1021/jm400879w. Epub 2014 Mar 7. J Med Chem. 2014. PMID: 24576160 Free PMC article.

10

Structural Requirements for CNS Active Opioid Glycopeptides.

Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Lefever M, et al. Among authors: bilsky ej. J Med Chem. 2015 Aug 13;58(15):5728-41. doi: 10.1021/acs.jmedchem.5b00014. Epub 2015 Jul 23. J Med Chem. 2015. PMID: 26125201

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