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Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.
Sci Immunol. 2021 Aug 19;6(62):eabl4340. doi: 10.1126/sciimmunol.abl4340.
Sci Immunol. 2021.
PMID: 34413139
Free PMC article.
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.
Manry J, Bastard P, Gervais A, Le Voyer T, Rosain J, Philippot Q, Michailidis E, Hoffmann HH, Eto S, Garcia-Prat M, Bizien L, Parra-Martínez A, Yang R, Haljasmägi L, Migaud M, Särekannu K, Maslovskaja J, de Prost N, Tandjaoui-Lambiotte Y, Luyt CE, Amador-Borrero B, Gaudet A, Poissy J, Morel P, Richard P, Cognasse F, Troya J, Trouillet-Assant S, Belot A, Saker K, Garçon P, Rivière JG, Lagier JC, Gentile S, Rosen LB, Shaw E, Morio T, Tanaka J, Dalmau D, Tharaux PL, Sene D, Stepanian A, Mégarbane B, Triantafyllia V, Fekkar A, Heath JR, Franco JL, Anaya JM, Solé-Violán J, Imberti L, Biondi A, Bonfanti P, Castagnoli R, Delmonte OM, Zhang Y, Snow AL, Holland SM, Biggs CM, Moncada-Vélez M, Arias AA, Lorenzo L, Boucherit S, Anglicheau D, Planas AM, Haerynck F, Duvlis S, Ozcelik T, Keles S, Bousfiha AA, El Bakkouri J, Ramirez-Santana C, Paul S, Pan-Hammarström Q, Hammarström L, Dupont A, Kurolap A, Metz CN, Aiuti A, Casari G, Lampasona V, Ciceri F, Barreiros LA, Dominguez-Garrido E, Vidigal M, Zatz M, van de Beek D, Sahanic S, Tancevski I, Stepanovskyy Y, Boyarchuk O, Nukui Y, Tsumura M, Vidaur L, Tangye SG, Burrel S, Duffy D, Quintana-Murci L, Klocperk A, Kann NY, Shcherbina A, Lau YL, Le…
See abstract for full author list ➔
Manry J, et al.
Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2200413119. doi: 10.1073/pnas.2200413119. Epub 2022 May 16.
Proc Natl Acad Sci U S A. 2022.
PMID: 35576468
Free PMC article.
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Anti-C5a antibody vilobelimab treatment and the effect on biomarkers of inflammation and coagulation in patients with severe COVID-19: a substudy of the phase 2 PANAMO trial.
Lim EHT, Vlaar APJ, Bos LDJ, van Vught LA, Boer AMT, Dujardin RWG, Habel M, Xu Z, Brouwer MC, van de Beek D, de Bruin S; Amsterdam UMC COVID-19 Biobank Investigators.
Lim EHT, et al.
Respir Res. 2022 Dec 24;23(1):375. doi: 10.1186/s12931-022-02278-1.
Respir Res. 2022.
PMID: 36566174
Free PMC article.
Clinical Trial.
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Clinical features and prognostic factors in Covid-19: A prospective cohort study.
de Bruin S, Bos LD, van Roon MA, Tuip-de Boer AM, Schuurman AR, Koel-Simmelinck MJA, Bogaard HJ, Tuinman PR, van Agtmael MA, Hamann J, Teunissen CE, Wiersinga WJ, Koos Zwinderman AH, Brouwer MC, van de Beek D, Vlaar APJ; Amsterdam UMC COVID-19 Biobank Investigators.
de Bruin S, et al.
EBioMedicine. 2021 May;67:103378. doi: 10.1016/j.ebiom.2021.103378. Epub 2021 May 14.
EBioMedicine. 2021.
PMID: 34000622
Free PMC article.
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Heart Rate Variability Analysis in Obstructive Sleep Apnoea Patients with Daytime Sleepiness.
Ucak S, Dissanayake HU, de Chazal P, Bin YS, Sutherland K, Setionago B, Tong B, Yee BJ, Kairaitis K, Wheatley JR, Piper AJ, Cistulli PA; Sydney Sleep Biobank Investigators.
Ucak S, et al.
Sleep. 2024 Mar 26:zsae075. doi: 10.1093/sleep/zsae075. Online ahead of print.
Sleep. 2024.
PMID: 38531670
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Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients.
Koning R, Bastard P, Casanova JL, Brouwer MC, van de Beek D; with the Amsterdam U.M.C. COVID-19 Biobank Investigators.
Koning R, et al.
Intensive Care Med. 2021 Jun;47(6):704-706. doi: 10.1007/s00134-021-06392-4. Epub 2021 Apr 9.
Intensive Care Med. 2021.
PMID: 33835207
Free PMC article.
No abstract available.
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