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IL-1beta and IL-2 convert human Treg into T(H)17 cells.
Deknuydt F, Bioley G, Valmori D, Ayyoub M. Deknuydt F, et al. Among authors: Bioley G. Clin Immunol. 2009 May;131(2):298-307. doi: 10.1016/j.clim.2008.12.008. Epub 2009 Feb 11. Clin Immunol. 2009. PMID: 19211307
Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t.
Ayyoub M, Deknuydt F, Raimbaud I, Dousset C, Leveque L, Bioley G, Valmori D. Ayyoub M, et al. Among authors: Bioley G. Proc Natl Acad Sci U S A. 2009 May 26;106(21):8635-40. doi: 10.1073/pnas.0900621106. Epub 2009 May 13. Proc Natl Acad Sci U S A. 2009. PMID: 19439651 Free PMC article.
Vaccination with a recombinant protein encoding the tumor-specific antigen NY-ESO-1 elicits an A2/157-165-specific CTL repertoire structurally distinct and of reduced tumor reactivity than that elicited by spontaneous immune responses to NY-ESO-1-expressing Tumors.
Bioley G, Guillaume P, Luescher I, Bhardwaj N, Mears G, Old L, Valmori D, Ayyoub M. Bioley G, et al. J Immunother. 2009 Feb-Mar;32(2):161-8. doi: 10.1097/CJI.0b013e31819302f6. J Immunother. 2009. PMID: 19238015
Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses.
Brandes M, Willimann K, Bioley G, Lévy N, Eberl M, Luo M, Tampé R, Lévy F, Romero P, Moser B. Brandes M, et al. Among authors: Bioley G. Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2307-12. doi: 10.1073/pnas.0810059106. Epub 2009 Jan 26. Proc Natl Acad Sci U S A. 2009. PMID: 19171897 Free PMC article.
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