Discovery of treatment for nerve agents targeting a new metabolic pathway.
Glaros T, Dhummakupt ES, Rizzo GM, McBride E, Carmany DO, Wright LKM, Forster JS, Renner JA, Moretz RW, Dorsey R, Marten MR, Huso W, Doan A, Dorsey CD, Phillips C, Benton B, Mach PM.
Glaros T, et al.
Arch Toxicol. 2020 Sep;94(9):3249-3264. doi: 10.1007/s00204-020-02820-4. Epub 2020 Jul 27.
Arch Toxicol. 2020.
PMID: 32720192
Free PMC article.
The inhibition of acetylcholinesterase is regarded as the primary toxic mechanism of action for chemical warfare agents. Recently, there have been numerous reports suggesting that metabolic processes could significantly contribute to toxicity. ...
The inhibition of acetylcholinesterase is regarded as the primary toxic mechanism of action for chemical warfare agents. Recently, th …