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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1939 1
1940 5
1941 8
1942 8
1943 5
1944 4
1945 14
1946 26
1947 45
1948 36
1949 30
1950 27
1951 30
1952 22
1953 24
1954 27
1955 20
1956 21
1957 17
1958 19
1959 19
1960 19
1961 31
1962 35
1963 50
1964 66
1965 39
1966 36
1967 35
1968 42
1969 64
1970 55
1971 34
1972 42
1973 30
1974 36
1975 67
1976 72
1977 75
1978 61
1979 74
1980 82
1981 87
1982 111
1983 160
1984 233
1985 330
1986 394
1987 447
1988 506
1989 652
1990 621
1991 555
1992 594
1993 700
1994 704
1995 718
1996 682
1997 742
1998 753
1999 820
2000 777
2001 780
2002 751
2003 728
2004 820
2005 920
2006 885
2007 864
2008 907
2009 900
2010 948
2011 986
2012 941
2013 970
2014 918
2015 924
2016 947
2017 863
2018 930
2019 941
2020 1007
2021 1015
2022 991
2023 926
2024 893
2025 978
2026 519

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32,913 results

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Page 1
Biotin: From Nutrition to Therapeutics.
Mock DM. Mock DM. J Nutr. 2017 Aug;147(8):1487-1492. doi: 10.3945/jn.116.238956. Epub 2017 Jul 12. J Nutr. 2017. PMID: 28701385 Free PMC article. Review.
Although frank symptomatic biotin deficiency is rare, some evidence suggests that marginal biotin deficiency occurs spontaneously in a substantial proportion of women during normal human pregnancy and might confer an increased risk of birth defects. Herein I review …
Although frank symptomatic biotin deficiency is rare, some evidence suggests that marginal biotin deficiency occurs spontaneou …
A Review of the Use of Biotin for Hair Loss.
Patel DP, Swink SM, Castelo-Soccio L. Patel DP, et al. Skin Appendage Disord. 2017 Aug;3(3):166-169. doi: 10.1159/000462981. Epub 2017 Apr 27. Skin Appendage Disord. 2017. PMID: 28879195 Free PMC article. Review.
METHODS: We conducted a PubMed search of all case reports and randomized clinical trials (RCTs) using the following terms: (biotin and hair); (biotin and supplementation and hair); (biotin supplementation); (biotin and alopecia); (biotin and nai …
METHODS: We conducted a PubMed search of all case reports and randomized clinical trials (RCTs) using the following terms: (biotin an …
Biotin Homeostasis and Human Disorders: Recent Findings and Perspectives.
Karachaliou CE, Livaniou E. Karachaliou CE, et al. Int J Mol Sci. 2024 Jun 14;25(12):6578. doi: 10.3390/ijms25126578. Int J Mol Sci. 2024. PMID: 38928282 Free PMC article. Review.
Biotin is not synthesized by human cells, but it is found in food and is also produced by intestinal bacteria. ...On the other hand, according to warnings of the Food and Drug Administration, USA, high biotin levels can affect clinical biotin-(strept)avidin a …
Biotin is not synthesized by human cells, but it is found in food and is also produced by intestinal bacteria. ...On the other hand, …
Biotin.
Zempleni J, Wijeratne SS, Hassan YI. Zempleni J, et al. Biofactors. 2009 Jan-Feb;35(1):36-46. doi: 10.1002/biof.8. Biofactors. 2009. PMID: 19319844 Free PMC article. Review.
This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological functions of biotin. Proteins such as holocarboxylase synthetase, biotinidase, and the biotin transporters SMVT and MCT1 play crucial ro …
This review describes mammalian biotin metabolism, biotin analysis, markers of biotin status, and biological functions …
Immunoassay design and biotin interference.
Dasgupta A. Dasgupta A. Adv Clin Chem. 2022;109:165-183. doi: 10.1016/bs.acc.2022.03.005. Epub 2022 May 5. Adv Clin Chem. 2022. PMID: 35953126 Review.
Although rare inborn errors of metabolism may cause biotin deficiency, these can be successfully treated with biotin supplementation. In general, normal individuals do not get any benefit from taking biotin supplement. ...In this review, I explore the biochem …
Although rare inborn errors of metabolism may cause biotin deficiency, these can be successfully treated with biotin supplemen …
Biotin: DNA to diet.
Karalia S, Meena VK. Karalia S, et al. J Nutr Biochem. 2025 Dec;146:110081. doi: 10.1016/j.jnutbio.2025.110081. Epub 2025 Aug 23. J Nutr Biochem. 2025. PMID: 40854404 Free article. Review.
Biotin is not synthesized by human cells; they take it up from intestinal gut bacteria or dietary sources. The estimated average requirement (EAR) for biotin is uncertain, but people of different ages require biotin between 5 and 35 mcg/d. ...
Biotin is not synthesized by human cells; they take it up from intestinal gut bacteria or dietary sources. The estimated average requ …
Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism.
Belda E, Voland L, Tremaroli V, Falony G, Adriouch S, Assmann KE, Prifti E, Aron-Wisnewsky J, Debédat J, Le Roy T, Nielsen T, Amouyal C, André S, Andreelli F, Blüher M, Chakaroun R, Chilloux J, Coelho LP, Dao MC, Das P, Fellahi S, Forslund S, Galleron N, Hansen TH, Holmes B, Ji B, Krogh Pedersen H, Le P, Le Chatelier E, Lewinter C, Mannerås-Holm L, Marquet F, Myridakis A, Pelloux V, Pons N, Quinquis B, Rouault C, Roume H, Salem JE, Sokolovska N, Søndertoft NB, Touch S, Vieira-Silva S; MetaCardis Consortium; Galan P, Holst J, Gøtze JP, Køber L, Vestergaard H, Hansen T, Hercberg S, Oppert JM, Nielsen J, Letunic I, Dumas ME, Stumvoll M, Pedersen OB, Bork P, Ehrlich SD, Zucker JD, Bäckhed F, Raes J, Clément K. Belda E, et al. Gut. 2022 Dec;71(12):2463-2480. doi: 10.1136/gutjnl-2021-325753. Epub 2022 Jan 11. Gut. 2022. PMID: 35017197 Free PMC article.
We found suboptimal circulating biotin levels in severe obesity and altered expression of biotin-associated genes in human adipose tissue. In mice, the absence or depletion of gut microbiota by antibiotics confirmed the microbial contribution to host biotin l …
We found suboptimal circulating biotin levels in severe obesity and altered expression of biotin-associated genes in human adi …
Biotin interference in routine clinical immunoassays.
Chiu KC, Jhan JR, Yan HN, Liao YC, Lu WH, Lee KY, Cheng LY, Yeh CK, Lee YF, Kuo CH, Chung KP, Chien TI. Chiu KC, et al. Pract Lab Med. 2025 May 1;45:e00472. doi: 10.1016/j.plabm.2025.e00472. eCollection 2025 Jul. Pract Lab Med. 2025. PMID: 40417451 Free PMC article.
We employed a biotin depletion method that effectively restored assay accuracy for older reagents, generally resulting in less than a 10 % change when biotin levels were below 400 ng/mL. ...The Abbott system demonstrated greater resilience to biotin interfere …
We employed a biotin depletion method that effectively restored assay accuracy for older reagents, generally resulting in less than a …
Biotin's Lessons in Drug Design.
McConnell DB. McConnell DB. J Med Chem. 2021 Nov 25;64(22):16319-16327. doi: 10.1021/acs.jmedchem.1c00975. Epub 2021 Nov 16. J Med Chem. 2021. PMID: 34784474 Free article.
This is made even more exceptional because biotin achieves this with a meagre molecular weight of 240 Da. Surprisingly, the approaches by which biotin achieves this are not in the standard repertoire of current medicinal chemistry practice. Biotin's biggest l …
This is made even more exceptional because biotin achieves this with a meagre molecular weight of 240 Da. Surprisingly, the approache …
Pharmacological Effects of Biotin in Animals.
Riveron-Negrete L, Fernandez-Mejia C. Riveron-Negrete L, et al. Mini Rev Med Chem. 2017;17(6):529-540. doi: 10.2174/1389557516666160923132611. Mini Rev Med Chem. 2017. PMID: 27670579 Review.
The bestsupported mechanism involved in the genetic effects of biotin is the soluble guanylate cyclase/protein kinase G (PKG) signaling cascade. Although there are commercially-available products containing pharmacological concentrations of biotin, the toxic effects …
The bestsupported mechanism involved in the genetic effects of biotin is the soluble guanylate cyclase/protein kinase G (PKG) signali …
32,913 results
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