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Solution Phase Peptide Synthesis: The Case of Biphalin.
Tymecka D, Misicka A. Tymecka D, et al. Methods Mol Biol. 2020;2103:1-11. doi: 10.1007/978-1-0716-0227-0_1. Methods Mol Biol. 2020. PMID: 31879915
Solution phase synthesis was the first developed and the only method for peptide synthesis until the solid phase peptide synthesis (SPPS) introduced by Merrifield revolutionized the way peptides and their analogues are prepared nowadays. ...Although biphal …
Solution phase synthesis was the first developed and the only method for peptide synthesis until the solid phase peptide synth …
The opioid peptide biphalin modulates human corneal epithelial wound healing in vitro.
Gedar Totuk OM, Yildiz E, Mollica A, Kabadayi K, Sahin A. Gedar Totuk OM, et al. J Fr Ophtalmol. 2021 Nov;44(9):1403-1412. doi: 10.1016/j.jfo.2020.09.007. Epub 2021 Aug 24. J Fr Ophtalmol. 2021. PMID: 34446298
The toxicity of biphalin at various concentrations was measured by the MTT assay. The effects of 1muM and 10muM biphalin on wound closure, cell migration and proliferation were tested in an in vitro scratch assay of HCECs. ...There was no significant difference betw …
The toxicity of biphalin at various concentrations was measured by the MTT assay. The effects of 1muM and 10muM biphalin on wo …
Solution Phase Peptide Synthesis: The Case of Biphalin.
Tymecka D, Misicka A. Tymecka D, et al. Methods Mol Biol. 2025;2931:143-154. doi: 10.1007/978-1-0716-4562-8_12. Methods Mol Biol. 2025. PMID: 40531455
Solution-phase synthesis was the first developed and the only method for peptide synthesis until the solid phase peptide synthesis (SPPS) introduced by Merrifield revolutionized the way peptides and their analogs are prepared nowadays. ...Due to the continued …
Solution-phase synthesis was the first developed and the only method for peptide synthesis until the solid phase peptide synth …
Biphalin, a dimeric opioid peptide, reduces neonatal hypoxia-ischemia brain injury in mice by the activation of PI3K/Akt signaling pathway.
Zhang JJ, Li Y, Chen S, Yang XF, Min JW. Zhang JJ, et al. J Chem Neuroanat. 2021 Sep;115:101967. doi: 10.1016/j.jchemneu.2021.101967. Epub 2021 May 14. J Chem Neuroanat. 2021. PMID: 33992725
The aim of this study was to investigate the neuroprotective effects of biphalin, a dimeric opioid peptide, in a mouse model of neonatal HI and the underlying mechanisms. ...Biphalin (10 mg/kg) significantly reduced the infarct volume and ameliorated brain ed …
The aim of this study was to investigate the neuroprotective effects of biphalin, a dimeric opioid peptide, in a mouse model o …
Neuroprotective potential of biphalin, multireceptor opioid peptide, against excitotoxic injury in hippocampal organotypic culture.
Kawalec M, Kowalczyk JE, Beresewicz M, Lipkowski AW, Zablocka B. Kawalec M, et al. Neurochem Res. 2011 Nov;36(11):2091-5. doi: 10.1007/s11064-011-0568-1. Epub 2011 Aug 13. Neurochem Res. 2011. PMID: 21842273 Free PMC article.
Biphalin is a dimeric opioid peptide that exhibits affinity for three types of opioid receptors (MOP, DOP and KOP). ...FINDINGS: (1) 0.025-0.1 muM biphalin reduces NMDA-induced neuronal damage; (2) biphalin neuroprotection is abolished by naltrexone; ( …
Biphalin is a dimeric opioid peptide that exhibits affinity for three types of opioid receptors (MOP, DOP and KOP). ...FINDING …
Crystal structure of biphalin sulfate: a multireceptor opioid peptide.
Flippen-Anderson JL, Deschamps JR, George C, Hruby VJ, Misicka A, Lipkowski AW. Flippen-Anderson JL, et al. J Pept Res. 2002 Mar;59(3):123-33. doi: 10.1034/j.1399-3011.2002.01967.x. J Pept Res. 2002. PMID: 11985706
Biphalin is a dimeric opioid peptide, composed of two tetrapeptides connected 'tail-to-tail', that exhibits a high affinity for all three opioid receptor types (i.e. mu, delta and kappa). ...Both halves of the molecule have a folded backbone conformation but differ …
Biphalin is a dimeric opioid peptide, composed of two tetrapeptides connected 'tail-to-tail', that exhibits a high affinity fo …
Biphalin-A Potent Opioid Agonist-As a Panacea for Opioid System-Dependent Pathophysiological Diseases?
Redkiewicz P, Dyniewicz J, Misicka A. Redkiewicz P, et al. Int J Mol Sci. 2021 Oct 21;22(21):11347. doi: 10.3390/ijms222111347. Int J Mol Sci. 2021. PMID: 34768778 Free PMC article. Review.
Biphalin, one of the opioid agonists, is a dimeric analog of enkephalin with a high affinity for opioid receptors. ...Hence, these receptors and their agonists, which play an important role in pain blocking, may also be involved in the regulation of other physiological fun …
Biphalin, one of the opioid agonists, is a dimeric analog of enkephalin with a high affinity for opioid receptors. ...Hence, these re …
Characterization and analysis of biphalin: an opioid peptide with a palindromic sequence.
Hettiarachchi K, Ridge S, Thomas DW, Olson L, Obi CR, Singh D. Hettiarachchi K, et al. J Pept Res. 2001 Feb;57(2):151-61. doi: 10.1034/j.1399-3011.2001.00819.x. J Pept Res. 2001. PMID: 11168898
Among the many opioid peptides developed to date as nonaddictive analgesics, biphalin has exhibited extraordinary high potency and many other desirable characteristics. ...This paper illustrates successful application of nonconventional techniques to characterize an …
Among the many opioid peptides developed to date as nonaddictive analgesics, biphalin has exhibited extraordinary high potency …
The influence of a synthetic growth hormone-releasing hormone analogue G11 and opioid peptide biphalin on selected fibroblasts parameters relevant to wound healing.
Redkiewicz P, Dyniewicz J, Witkowska E, Misicka A, Lipiński PFJ. Redkiewicz P, et al. J Pept Sci. 2023 Sep;29(9):e3487. doi: 10.1002/psc.3487. Epub 2023 Mar 20. J Pept Sci. 2023. PMID: 36898693
In this work, we examine the proregenerative potential of two peptides, G11 (a trypsin-resistant analogue of growth hormone-releasing hormone [GHRH]) and biphalin (opioid peptide), and their combination in vitro on human fibroblasts (BJ). G11, biphalin …
In this work, we examine the proregenerative potential of two peptides, G11 (a trypsin-resistant analogue of growth hormone-releasing …
Biphalin: The Foundation of Bivalent Ligands.
Cowell SM, Lee YS. Cowell SM, et al. Curr Med Chem. 2016;23(29):3267-3284. doi: 10.2174/0929867323666160510122731. Curr Med Chem. 2016. PMID: 27160537 Review.
As a straight ligand, biphalin has allowed scientists to increase efficacy by direct modification of the residues to affect the message-address interactions with receptors. ...Lipkowski. This review gives the foundation of biphalin and in turn celebrates the contrib …
As a straight ligand, biphalin has allowed scientists to increase efficacy by direct modification of the residues to affect the messa …
84 results