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Perceptions of epigenetics.
Bird A. Bird A. Nature. 2007 May 24;447(7143):396-8. doi: 10.1038/nature05913. Nature. 2007. PMID: 17522671
Nevertheless, during the past year, more than 2,500 articles, numerous scientific meetings and a new journal were devoted to the subject of epigenetics. It encompasses some of the most exciting contemporary biology and is portrayed by the popular press as a revoluti …
Nevertheless, during the past year, more than 2,500 articles, numerous scientific meetings and a new journal were devoted to the subj …
Transcriptional repression by methylation of CpG.
Meehan R, Lewis J, Cross S, Nan X, Jeppesen P, Bird A. Meehan R, et al. Among authors: bird a. J Cell Sci Suppl. 1992;16:9-14. doi: 10.1242/jcs.1992.supplement_16.2. J Cell Sci Suppl. 1992. PMID: 1297654 Review.
The essentials of DNA methylation.
Bird A. Bird A. Cell. 1992 Jul 10;70(1):5-8. doi: 10.1016/0092-8674(92)90526-i. Cell. 1992. PMID: 1377983 Review. No abstract available.
DNA methylation and chromatin structure.
Lewis J, Bird A. Lewis J, et al. Among authors: bird a. FEBS Lett. 1991 Jul 22;285(2):155-9. doi: 10.1016/0014-5793(91)80795-5. FEBS Lett. 1991. PMID: 1855583 Review.
A protein (MeCP) which binds specifically to methylated DNA has been identified. The properties of MeCP could account for the effects of DNA methylation on both chromatin and transcription....
A protein (MeCP) which binds specifically to methylated DNA has been identified. The properties of MeCP could account for the effects
CpG islands and genes.
Cross SH, Bird AP. Cross SH, et al. Among authors: bird ap. Curr Opin Genet Dev. 1995 Jun;5(3):309-14. doi: 10.1016/0959-437x(95)80044-1. Curr Opin Genet Dev. 1995. PMID: 7549424 Review.
Binding of histone H1 to DNA is indifferent to methylation at CpG sequences.
Campoy FJ, Meehan RR, McKay S, Nixon J, Bird A. Campoy FJ, et al. Among authors: bird a. J Biol Chem. 1995 Nov 3;270(44):26473-81. doi: 10.1074/jbc.270.44.26473. J Biol Chem. 1995. PMID: 7592864
Based on a variety of assays (bandshifts, filter-binding assays, Southwestern blots, and nuclease sensitivity assays), we conclude that H1 has no significant preference for binding to naked methylated DNA. Similarly, H1 showed the same affinities for methylated and non-met …
Based on a variety of assays (bandshifts, filter-binding assays, Southwestern blots, and nuclease sensitivity assays), we conclude th …
Gene number, noise reduction and biological complexity.
Bird AP. Bird AP. Trends Genet. 1995 Mar;11(3):94-100. doi: 10.1016/S0168-9525(00)89009-5. Trends Genet. 1995. PMID: 7732579 Review.
Functions for DNA methylation in vertebrates.
Bird AP. Bird AP. Cold Spring Harb Symp Quant Biol. 1993;58:281-5. doi: 10.1101/sqb.1993.058.01.033. Cold Spring Harb Symp Quant Biol. 1993. PMID: 7956040 Review.
DNA methylation is ancestrally a mechanism for neutralizing potentially damaging DNA elements in the genome. The genomes of most multicellular organisms contain a small fraction of methylated DNA that contains the methylated elements, whereas the organism's own gene …
DNA methylation is ancestrally a mechanism for neutralizing potentially damaging DNA elements in the genome. The genomes of most mult …
Sp1 sites in the mouse aprt gene promoter are required to prevent methylation of the CpG island.
Macleod D, Charlton J, Mullins J, Bird AP. Macleod D, et al. Among authors: bird ap. Genes Dev. 1994 Oct 1;8(19):2282-92. doi: 10.1101/gad.8.19.2282. Genes Dev. 1994. PMID: 7958895
In an attempt to find the mechanism by which CpG islands remain free of methylation we have undertaken a detailed examination of the mouse adenine phosphoribosyltransferase (aprt) gene. This housekeeping gene has a CpG island that extends over the gene promoter and …
In an attempt to find the mechanism by which CpG islands remain free of methylation we have undertaken a detailed examination of the …
Purification of CpG islands using a methylated DNA binding column.
Cross SH, Charlton JA, Nan X, Bird AP. Cross SH, et al. Among authors: bird ap. Nat Genet. 1994 Mar;6(3):236-44. doi: 10.1038/ng0394-236. Nat Genet. 1994. PMID: 8012384
CpG islands are short stretches of DNA containing a high density of non-methylated CpG dinucleotides, predominantly associated with coding regions. We have constructed an affinity matrix that contains the methyl-CpG binding domain from the rat chromosomal protein MeCP2, at …
CpG islands are short stretches of DNA containing a high density of non-methylated CpG dinucleotides, predominantly associated with c …
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