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TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.
Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ. Bird TG, et al. Sci Transl Med. 2018 Aug 15;10(454):eaan1230. doi: 10.1126/scitranslmed.aan1230. Sci Transl Med. 2018. PMID: 30111642 Free PMC article.
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
Lu WY, Bird TG, Boulter L, Tsuchiya A, Cole AM, Hay T, Guest RV, Wojtacha D, Man TY, Mackinnon A, Ridgway RA, Kendall T, Williams MJ, Jamieson T, Raven A, Hay DC, Iredale JP, Clarke AR, Sansom OJ, Forbes SJ. Lu WY, et al. Among authors: bird tg. Nat Cell Biol. 2015 Aug;17(8):971-983. doi: 10.1038/ncb3203. Epub 2015 Jul 20. Nat Cell Biol. 2015. PMID: 26192438 Free PMC article.
Paracrine cellular senescence exacerbates biliary injury and impairs regeneration.
Ferreira-Gonzalez S, Lu WY, Raven A, Dwyer B, Man TY, O'Duibhir E, Lewis PJS, Campana L, Kendall TJ, Bird TG, Tarrats N, Acosta JC, Boulter L, Forbes SJ. Ferreira-Gonzalez S, et al. Among authors: bird tg. Nat Commun. 2018 Mar 9;9(1):1020. doi: 10.1038/s41467-018-03299-5. Nat Commun. 2018. PMID: 29523787 Free PMC article.
Galectin-3 regulates hepatic progenitor cell expansion during liver injury.
Hsieh WC, Mackinnon AC, Lu WY, Jung J, Boulter L, Henderson NC, Simpson KJ, Schotanus B, Wojtacha D, Bird TG, Medine CN, Hay DC, Sethi T, Iredale JP, Forbes SJ. Hsieh WC, et al. Among authors: bird tg. Gut. 2015 Feb;64(2):312-21. doi: 10.1136/gutjnl-2013-306290. Epub 2014 May 16. Gut. 2015. PMID: 24837171
57 results