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Birth Outcomes for Pregnant Women with HIV Using Tenofovir-Emtricitabine.
Rough K, Seage GR 3rd, Williams PL, Hernandez-Diaz S, Huo Y, Chadwick EG, Currier JS, Hoffman RM, Barr E, Shapiro DE, Patel K; PHACS and the IMPAACT P1025 Study Teams. Rough K, et al. N Engl J Med. 2018 Apr 26;378(17):1593-1603. doi: 10.1056/NEJMoa1701666. N Engl J Med. 2018. PMID: 29694825 Free PMC article.
BACKGROUND: In a previous trial of antiretroviral therapy (ART) involving pregnant women with human immunodeficiency virus (HIV) infection, those randomly assigned to receive tenofovir, emtricitabine, and ritonavir-boosted lopinavir (TDF-FTC-LPV …
BACKGROUND: In a previous trial of antiretroviral therapy (ART) involving pregnant women with human immunodeficiency virus ( …
Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention.
Fowler MG, Qin M, Fiscus SA, Currier JS, Flynn PM, Chipato T, McIntyre J, Gnanashanmugam D, Siberry GK, Coletti AS, Taha TE, Klingman KL, Martinson FE, Owor M, Violari A, Moodley D, Theron GB, Bhosale R, Bobat R, Chi BH, Strehlau R, Mlay P, Loftis AJ, Browning R, Fenton T, Purdue L, Basar M, Shapiro DE, Mofenson LM; IMPAACT 1077BF/1077FF PROMISE Study Team. Fowler MG, et al. N Engl J Med. 2016 Nov 3;375(18):1726-1737. doi: 10.1056/NEJMoa1511691. N Engl J Med. 2016. PMID: 27806243 Free PMC article. Clinical Trial.
BACKGROUND: Randomized-trial data on the risks and benefits of antiretroviral therapy (ART) as compared with zidovudine and single-dose nevirapine to prevent transmission of the human immunodeficiency virus (HIV) in HIV-infected pregnant women with hig …
BACKGROUND: Randomized-trial data on the risks and benefits of antiretroviral therapy (ART) as compared with zidovudine and single-dose nevi …
Pregnancy outcomes in women living with HIV and HIV-negative women in South Africa: Cohort analysis based on bias-corrected gestational age.
Malaba TR, Mukonda E, Matjila M, Madlala HP, Myer L, Newell ML; PIMS Study Group. Malaba TR, et al. Paediatr Perinat Epidemiol. 2021 Dec 10. doi: 10.1111/ppe.12837. Online ahead of print. Paediatr Perinat Epidemiol. 2021. PMID: 34890057
METHODS: Pregnant women, HIV-negative or living with HIV (WLHIV), were enrolled at first antenatal care visit and followed through delivery. ...RESULTS: Of 3952 women enrolled, 37% were WLHIV (mostly using tenofovir + emtricitabine
METHODS: Pregnant women, HIV-negative or living with HIV (WLHIV), were enrolled at first antenatal care visit an …
Does HIV infection modify the relationship between pre-pregnancy body mass index and adverse birth outcomes?
Bengtson AM, Phillips TK, le Roux SM, Brittain K, Zerbe A, Madlala H, Malaba T, Petro G, Abrams EJ, Myer L. Bengtson AM, et al. Paediatr Perinat Epidemiol. 2020 Nov;34(6):713-723. doi: 10.1111/ppe.12688. Epub 2020 Jun 3. Paediatr Perinat Epidemiol. 2020. PMID: 32490582
HIV-infected women initiated ART (tenofovir-emtricitabine/lamivudine-efavirenz) in pregnancy. ...We used modified Poisson regression to estimate risk ratios (RR) for associations between pre-pregnancy BMI and adverse birth outcomes and ex
HIV-infected women initiated ART (tenofovir-emtricitabine/lamivudine-efavirenz) in pregnancy. ...We used modifie
Antiretroviral therapy use during pregnancy and adverse birth outcomes in South African women.
Malaba TR, Phillips T, Le Roux S, Brittain K, Zerbe A, Petro G, Ronan A, McIntyre JA, Abrams EJ, Myer L. Malaba TR, et al. Int J Epidemiol. 2017 Oct 1;46(5):1678-1689. doi: 10.1093/ije/dyx136. Int J Epidemiol. 2017. PMID: 29040569 Free PMC article.
In analysis we compared birth outcomes between HIV-infected and -uninfected women, and HIV-infected women who initiated ART before vs during pregnancy. RESULTS: In 1554 women (mean age 29 years) with live singleton births at …
In analysis we compared birth outcomes between HIV-infected and -uninfected women, and HIV-infected wo
Comparative safety of dolutegravir-based or efavirenz-based antiretroviral treatment started during pregnancy in Botswana: an observational study.
Zash R, Jacobson DL, Diseko M, Mayondi G, Mmalane M, Essex M, Gaolethe T, Petlo C, Lockman S, Holmes LB, Makhema J, Shapiro RL. Zash R, et al. Lancet Glob Health. 2018 Jul;6(7):e804-e810. doi: 10.1016/S2214-109X(18)30218-3. Epub 2018 Jun 4. Lancet Glob Health. 2018. PMID: 29880310 Free PMC article.
In 2016, Botswana changed first-line ART from efavirenz-tenofovir-emtricitabine to dolutegravir-tenofovir-emtricitabine, including for pregnant women. ...INTERPRETATION: Adverse birth outcomes were similar among pregnant
In 2016, Botswana changed first-line ART from efavirenz-tenofovir-emtricitabine to dolutegravir-tenofovir-emtricitab
Population pharmacokinetics of nevirapine in HIV-1-infected pregnant women and their neonates.
Benaboud S, Ekouévi DK, Urien S, Rey E, Arrivé E, Blanche S, Gray G, Sim KL, Avit D, McIntyre J, Nerrienet E, Dabis F, Tréluyer JM, Hirt D; TEmAA ANRS 12109 Study Group. Benaboud S, et al. Antimicrob Agents Chemother. 2011 Jan;55(1):331-7. doi: 10.1128/AAC.00631-10. Epub 2010 Oct 18. Antimicrob Agents Chemother. 2011. PMID: 20956588 Free PMC article. Clinical Trial.
The aim of the present study was to describe the nevirapine (NVP) pharmacokinetics (PK) in pregnant women and their neonates and to evaluate the transplacental drug transfer and administration scheme for the prevention of mother-to-child transmission. Thirty-eight …
The aim of the present study was to describe the nevirapine (NVP) pharmacokinetics (PK) in pregnant women and their neonates a …
Association between HIV antiretroviral therapy and preterm birth based on antenatal ultrasound gestational age determination: a comparative analysis.
Venkatesh KK, Farhad M, Fenton T, Moodley D, Naik S, Nakabiito C, Fairlie L, Fowler MG, Stringer JSA, Chi BH. Venkatesh KK, et al. AIDS. 2019 Dec 1;33(15):2403-2413. doi: 10.1097/QAD.0000000000002367. AIDS. 2019. PMID: 31764105 Free PMC article. Clinical Trial.
OBJECTIVE: To evaluate the association between HIV antiretroviral therapy (ART) and preterm birth (PTB), when defined by gold standard antenatal ultrasound versus newborn exam. ...We fit multivariable logistic regression models, adjusting for maternal characteristic …
OBJECTIVE: To evaluate the association between HIV antiretroviral therapy (ART) and preterm birth (PTB), when defined by gold …