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Birth Outcomes for Pregnant Women with HIV Using Tenofovir-Emtricitabine.
Rough K, Seage GR 3rd, Williams PL, Hernandez-Diaz S, Huo Y, Chadwick EG, Currier JS, Hoffman RM, Barr E, Shapiro DE, Patel K; PHACS and the IMPAACT P1025 Study Teams. Rough K, et al. N Engl J Med. 2018 Apr 26;378(17):1593-1603. doi: 10.1056/NEJMoa1701666. N Engl J Med. 2018. PMID: 29694825 Free PMC article.
BACKGROUND: In a previous trial of antiretroviral therapy (ART) involving pregnant women with human immunodeficiency virus (HIV) infection, those randomly assigned to receive tenofovir, emtricitabine, and ritonavir-boosted lopinavir (TDF-FTC-LPV …
BACKGROUND: In a previous trial of antiretroviral therapy (ART) involving pregnant women with human immunodeficiency virus ( …
Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention.
Fowler MG, Qin M, Fiscus SA, Currier JS, Flynn PM, Chipato T, McIntyre J, Gnanashanmugam D, Siberry GK, Coletti AS, Taha TE, Klingman KL, Martinson FE, Owor M, Violari A, Moodley D, Theron GB, Bhosale R, Bobat R, Chi BH, Strehlau R, Mlay P, Loftis AJ, Browning R, Fenton T, Purdue L, Basar M, Shapiro DE, Mofenson LM; IMPAACT 1077BF/1077FF PROMISE Study Team. Fowler MG, et al. N Engl J Med. 2016 Nov 3;375(18):1726-1737. doi: 10.1056/NEJMoa1511691. N Engl J Med. 2016. PMID: 27806243 Free PMC article. Clinical Trial.
BACKGROUND: Randomized-trial data on the risks and benefits of antiretroviral therapy (ART) as compared with zidovudine and single-dose nevirapine to prevent transmission of the human immunodeficiency virus (HIV) in HIV-infected pregnant women with hig …
BACKGROUND: Randomized-trial data on the risks and benefits of antiretroviral therapy (ART) as compared with zidovudine and single-dose nevi …
Comparative safety of dolutegravir-based or efavirenz-based antiretroviral treatment started during pregnancy in Botswana: an observational study.
Zash R, Jacobson DL, Diseko M, Mayondi G, Mmalane M, Essex M, Gaolethe T, Petlo C, Lockman S, Holmes LB, Makhema J, Shapiro RL. Zash R, et al. Lancet Glob Health. 2018 Jul;6(7):e804-e810. doi: 10.1016/S2214-109X(18)30218-3. Epub 2018 Jun 4. Lancet Glob Health. 2018. PMID: 29880310 Free PMC article. Clinical Trial.
In 2016, Botswana changed first-line ART from efavirenz-tenofovir-emtricitabine to dolutegravir-tenofovir-emtricitabine, including for pregnant women. ...INTERPRETATION: Adverse birth outcomes were similar among pregnant
In 2016, Botswana changed first-line ART from efavirenz-tenofovir-emtricitabine to dolutegravir-tenofovir-emtricitab
Antiretroviral therapy use during pregnancy and adverse birth outcomes in South African women.
Malaba TR, Phillips T, Le Roux S, Brittain K, Zerbe A, Petro G, Ronan A, McIntyre JA, Abrams EJ, Myer L. Malaba TR, et al. Int J Epidemiol. 2017 Oct 1;46(5):1678-1689. doi: 10.1093/ije/dyx136. Int J Epidemiol. 2017. PMID: 29040569 Free PMC article.
In analysis we compared birth outcomes between HIV-infected and -uninfected women, and HIV-infected women who initiated ART before vs during pregnancy. RESULTS: In 1554 women (mean age 29 years) with live singleton births at …
In analysis we compared birth outcomes between HIV-infected and -uninfected women, and HIV-infected wo
Association between HIV antiretroviral therapy and preterm birth based on antenatal ultrasound gestational age determination: a comparative analysis.
Venkatesh KK, Farhad M, Fenton T, Moodley D, Naik S, Nakabiito C, Fairlie L, Fowler MG, Stringer JSA, Chi BH. Venkatesh KK, et al. AIDS. 2019 Dec 1;33(15):2403-2413. doi: 10.1097/QAD.0000000000002367. AIDS. 2019. PMID: 31764105
OBJECTIVE: To evaluate the association between HIV antiretroviral therapy (ART) and preterm birth (PTB), when defined by gold standard antenatal ultrasound versus newborn exam. ...The primary exposure was the trial's antiretroviral strategies: zidovudine with …
OBJECTIVE: To evaluate the association between HIV antiretroviral therapy (ART) and preterm birth (PTB), when defined by gold …
Does HIV infection modify the relationship between pre-pregnancy body mass index and adverse birth outcomes?
Bengtson AM, Phillips TK, le Roux SM, Brittain K, Zerbe A, Madlala H, Malaba T, Petro G, Abrams EJ, Myer L. Bengtson AM, et al. Paediatr Perinat Epidemiol. 2020 Jun 3. doi: 10.1111/ppe.12688. Online ahead of print. Paediatr Perinat Epidemiol. 2020. PMID: 32490582
OBJECTIVES: To examine associations between pre-pregnancy body mass index (BMI) and adverse birth outcomes, and if they differ by HIV status. ...HIV-infected women initiated ART (tenofovir-emtricitabine/lamivudine-efavirenz) in pre …
OBJECTIVES: To examine associations between pre-pregnancy body mass index (BMI) and adverse birth outcomes, and if they differ …
Population pharmacokinetics of nevirapine in HIV-1-infected pregnant women and their neonates.
Benaboud S, Ekouévi DK, Urien S, Rey E, Arrivé E, Blanche S, Gray G, Sim KL, Avit D, McIntyre J, Nerrienet E, Dabis F, Tréluyer JM, Hirt D; TEmAA ANRS 12109 Study Group. Benaboud S, et al. Antimicrob Agents Chemother. 2011 Jan;55(1):331-7. doi: 10.1128/AAC.00631-10. Epub 2010 Oct 18. Antimicrob Agents Chemother. 2011. PMID: 20956588 Free PMC article. Clinical Trial.
Thirty-eight HIV-1-infected pregnant women were administered one tablet of NVP (200 mg) and two tablets of tenofovir-emtricitabine (Truvada) at the initiation of labor. ...Thus, the administration of tenofovir-emtricitabine for at …
Thirty-eight HIV-1-infected pregnant women were administered one tablet of NVP (200 mg) and two tablets of tenofovir
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