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The chemical biology and coordination chemistry of putrebactin, avaroferrin, bisucaberin, and alcaligin.
Codd R, Soe CZ, Pakchung AAH, Sresutharsan A, Brown CJM, Tieu W. Codd R, et al. J Biol Inorg Chem. 2018 Oct;23(7):969-982. doi: 10.1007/s00775-018-1585-1. Epub 2018 Jun 26. J Biol Inorg Chem. 2018. PMID: 29946977 Review.
Dihydroxamic acid macrocyclic siderophores comprise four members: putrebactin (putH(2)), avaroferrin (avaH(2)), bisucaberin (bisH(2)), and alcaligin (alcH(2)). This mini-review collates studies of the chemical biology and coordination chemistry of these macrocycles, with a …
Dihydroxamic acid macrocyclic siderophores comprise four members: putrebactin (putH(2)), avaroferrin (avaH(2)), bisucaberin (bisH(2)) …
Bisucaberin B, a linear hydroxamate class siderophore from the marine bacterium Tenacibaculum mesophilum.
Fujita MJ, Nakano K, Sakai R. Fujita MJ, et al. Molecules. 2013 Apr 2;18(4):3917-26. doi: 10.3390/molecules18043917. Molecules. 2013. PMID: 23549298 Free PMC article.
A siderophore, named bisucaberin B, was isolated from Tenacibaculum mesophilum bacteria separated from a marine sponge collected in the Republic of Palau. Using spectroscopic and chemical methods, the structure of bisucaberin B (1) was clearly determined to be a lin …
A siderophore, named bisucaberin B, was isolated from Tenacibaculum mesophilum bacteria separated from a marine sponge collected in t …
Bisucaberin biosynthesis: an adenylating domain of the BibC multi-enzyme catalyzes cyclodimerization of N-hydroxy-N-succinylcadaverine.
Kadi N, Song L, Challis GL. Kadi N, et al. Chem Commun (Camb). 2008 Nov 7;(41):5119-21. doi: 10.1039/b813029a. Epub 2008 Sep 22. Chem Commun (Camb). 2008. PMID: 18956041
The bisucaberin biosynthetic gene cluster has been identified in Vibrio salmonicida and a domain from within the BibC multienzyme encoded by the cluster has been shown to catalyse ATP-dependent dimerisation and macrocyclisation of N-hydroxy-N-succinylcadaverine to form …
The bisucaberin biosynthetic gene cluster has been identified in Vibrio salmonicida and a domain from within the BibC multienzyme enc …
Engineering siderophores.
Rütschlin S, Böttcher T. Rütschlin S, et al. Methods Enzymol. 2020;633:29-47. doi: 10.1016/bs.mie.2019.10.030. Epub 2019 Nov 20. Methods Enzymol. 2020. PMID: 32046852
Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. I. Taxonomy of the producing organism, isolation and biological properties.
Kameyama T, Takahashi A, Kurasawa S, Ishizuka M, Okami Y, Takeuchi T, Umezawa H. Kameyama T, et al. J Antibiot (Tokyo). 1987 Dec;40(12):1664-70. doi: 10.7164/antibiotics.40.1664. J Antibiot (Tokyo). 1987. PMID: 2962972 Free article.
The activity of bisucaberin was specifically inhibited by ferric ion. Bisucaberin showed direct cytostasis for tumor cells but did not cause cytolysis in the absence of macrophages. Cytostasis by bisucaberin was attributable to the specific inhibition of DNA …
The activity of bisucaberin was specifically inhibited by ferric ion. Bisucaberin showed direct cytostasis for tumor cells but …
Bisucaberin, a new siderophore, sensitizing tumor cells to macrophage-mediated cytolysis. II. Physico-chemical properties and structure determination.
Takahashi A, Nakamura H, Kameyama T, Kurasawa S, Naganawa H, Okami Y, Takeuchi T, Umezawa H, Iitaka Y. Takahashi A, et al. J Antibiot (Tokyo). 1987 Dec;40(12):1671-6. doi: 10.7164/antibiotics.40.1671. J Antibiot (Tokyo). 1987. PMID: 2962973 Free article.
The structure of bisucaberin, a new siderophore, was determined to be 1,12-dihydroxy-1,6,12,17-tetraazacyclodocosane-2,5,13,16-tetron e by spectroscopic analysis and X-ray crystallographic analysis. The molecule of bisucaberin consists of a cyclic dimer of 1-hydroxy …
The structure of bisucaberin, a new siderophore, was determined to be 1,12-dihydroxy-1,6,12,17-tetraazacyclodocosane-2,5,13,16-tetron …
Interactions of TonB-dependent transporter FoxA with siderophores and antibiotics that affect binding, uptake, and signal transduction.
Chan DCK, Josts I, Koteva K, Wright GD, Tidow H, Burrows LL. Chan DCK, et al. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2221253120. doi: 10.1073/pnas.2221253120. Epub 2023 Apr 12. Proc Natl Acad Sci U S A. 2023. PMID: 37043535 Free PMC article.
Here, we show that FoxA also transports the xenosiderophore bisucaberin and describe at 2.5 A resolution the crystal structure of bisucaberin bound to FoxA. Bisucaberin is distinct from other siderophores because it forms a 3:2 rather than 1:1 siderophore-iro …
Here, we show that FoxA also transports the xenosiderophore bisucaberin and describe at 2.5 A resolution the crystal structure of …
A chimeric siderophore halts swarming Vibrio.
Böttcher T, Clardy J. Böttcher T, et al. Angew Chem Int Ed Engl. 2014 Mar 24;53(13):3510-3. doi: 10.1002/anie.201310729. Epub 2014 Feb 24. Angew Chem Int Ed Engl. 2014. PMID: 24615751 Free PMC article.
Avaroferrin, a previously unreported cyclic dihydroxamate siderophore, is a chimera of two well-known siderophores: putrebactin and bisucaberin. The sequenced genome of S. algae revealed avaroferrin's biosynthetic gene cluster to be a mashup of putrebactin and bisucaber
Avaroferrin, a previously unreported cyclic dihydroxamate siderophore, is a chimera of two well-known siderophores: putrebactin and bisuc
Heterologous production of bisucaberin using a biosynthetic gene cluster cloned from a deep sea metagenome.
Fujita MJ, Kimura N, Yokose H, Otsuka M. Fujita MJ, et al. Mol Biosyst. 2012 Feb;8(2):482-5. doi: 10.1039/c1mb05431g. Epub 2011 Nov 3. Mol Biosyst. 2012. PMID: 22051782
The gene cluster was successfully expressed in Escherichia coli to produce bisucaberin, a siderophore originally reported from the marine bacterium Alteromonas haloplanktis. The cloned bisucaberin biosynthetic gene cluster was moderately similar to that of the known …
The gene cluster was successfully expressed in Escherichia coli to produce bisucaberin, a siderophore originally reported from the ma …
Cloning of the Bisucaberin B Biosynthetic Gene Cluster from the Marine Bacterium Tenacibaculum mesophilum, and Heterologous Production of Bisucaberin B.
Fujita MJ, Goto Y, Sakai R. Fujita MJ, et al. Mar Drugs. 2018 Sep 19;16(9):342. doi: 10.3390/md16090342. Mar Drugs. 2018. PMID: 30235820 Free PMC article.
The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. ...Heterologous expression of the key enzyme, Bsb …
The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was c …
24 results