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HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis.
Hofmann TG, Glas C, Bitomsky N. Hofmann TG, et al. Among authors: bitomsky n. Bioessays. 2013 Jan;35(1):55-64. doi: 10.1002/bies.201200060. Epub 2012 Nov 21. Bioessays. 2013. PMID: 23169233 Review.
HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism.
Conrad E, Polonio-Vallon T, Meister M, Matt S, Bitomsky N, Herbel C, Liebl M, Greiner V, Kriznik B, Schumacher S, Krieghoff-Henning E, Hofmann TG. Conrad E, et al. Among authors: bitomsky n. Cell Death Differ. 2016 Jan;23(1):110-22. doi: 10.1038/cdd.2015.75. Epub 2015 Jun 26. Cell Death Differ. 2016. PMID: 26113041 Free PMC article.
Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death.
Bitomsky N, Conrad E, Moritz C, Polonio-Vallon T, Sombroek D, Schultheiss K, Glas C, Greiner V, Herbel C, Mantovani F, del Sal G, Peri F, Hofmann TG. Bitomsky N, et al. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):E4203-12. doi: 10.1073/pnas.1310001110. Epub 2013 Oct 21. Proc Natl Acad Sci U S A. 2013. PMID: 24145406 Free PMC article.
Hypoxia suppresses chemotherapeutic drug-induced p53 Serine 46 phosphorylation by triggering HIPK2 degradation.
Moehlenbrink J, Bitomsky N, Hofmann TG. Moehlenbrink J, et al. Among authors: bitomsky n. Cancer Lett. 2010 Jun 1;292(1):119-24. doi: 10.1016/j.canlet.2009.11.016. Epub 2009 Dec 16. Cancer Lett. 2010. PMID: 20018442