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The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders.
Borbye-Lorenzen N, Zhu Z, Agerbo E, Albiñana C, Benros ME, Bian B, Børglum AD, Bulik CM, Debost JPG, Grove J, Hougaard DM, McRae AF, Mors O, Mortensen PB, Musliner KL, Nordentoft M, Petersen LV, Privé F, Sidorenko J, Skogstrand K, Werge T, Wray NR, Vilhjálmsson BJ, McGrath JJ. Borbye-Lorenzen N, et al. Cell Genom. 2023 Dec 13;3(12):100457. doi: 10.1016/j.xgen.2023.100457. eCollection 2023 Dec 13. Cell Genom. 2023. PMID: 38116117 Free PMC article.
The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found th …
The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between …
Levels of type XVII collagen (BP180) ectodomain are elevated in circulation from patients with multiple cancer types and is prognostic for patients with metastatic colorectal cancer.
Crespo-Bravo M, Thorlacius-Ussing J, Nissen NI, Pedersen RS, Boisen MK, Liljefors M, Johansen AZ, Johansen JS, Karsdal MA, Willumsen N. Crespo-Bravo M, et al. BMC Cancer. 2023 Oct 6;23(1):949. doi: 10.1186/s12885-023-11470-5. BMC Cancer. 2023. PMID: 37803411 Free PMC article.
When evaluated by multivariate Cox regression analysis, high PRO-C17 was predictive for poor OS independent of risk factors and the tumor fibrosis biomarker PRO-C3. CONCLUSION: PRO-C17 measures the ectodomain of type XVII collagen in serum and is a promising non-invasive b …
When evaluated by multivariate Cox regression analysis, high PRO-C17 was predictive for poor OS independent of risk factors and the tumor fi …
Autoreactivity against Denatured Type III Collagen Is Significantly Decreased in Serum from Patients with Cancer Compared to Healthy Controls.
Jensen C, Drobinski P, Thorlacius-Ussing J, Karsdal MA, Bay-Jensen AC, Willumsen N. Jensen C, et al. Int J Mol Sci. 2023 Apr 11;24(8):7067. doi: 10.3390/ijms24087067. Int J Mol Sci. 2023. PMID: 37108227 Free PMC article.

Moreover, the association between anti-dCol3 levels and type III collagen degradation (C3M) and formation (PRO-C3) was investigated. Anti-dCol3 levels were significantly lower in patients with bladder (p = 0.0007), breast (p = 0.0002), colorectal (p < 0.0001), head and

…
Moreover, the association between anti-dCol3 levels and type III collagen degradation (C3M) and formation (PRO-C3) was investigated. …
C-X Bond Activation by Palladium: Steric Shielding versus Steric Attraction.
Hansen T, Sun X, Dalla Tiezza M, van Zeist WJ, van Stralen JNP, Geerke DP, Wolters LP, Poater J, Hamlin TA, Bickelhaupt FM. Hansen T, et al. Chemistry. 2022 Aug 4;28(44):e202201093. doi: 10.1002/chem.202201093. Epub 2022 Jun 16. Chemistry. 2022. PMID: 35420229 Free PMC article.
The C-X bond activation (X = H, C) of a series of substituted C(n)-H and C(n)-C(m) bonds with C(n) and C(m) = H(3) C- (methyl, 0), CH(3) H(2) C- (primary, 1), (CH(3) )(2) HC- (secondary, 2), (CH(3) )(3) C- (tertiary, 3) by palladium were investigated using relativis …
The C-X bond activation (X = H, C) of a series of substituted C(n)-H and C(n)-C(m) bonds with C(n) and C(m) = H(3) C- (methyl, …
Abundance of organosulfates derived from biogenic volatile organic compounds: Seasonal and spatial contrasts at four sites in China.
Wang Y, Ma Y, Kuang B, Lin P, Liang Y, Huang C, Yu JZ. Wang Y, et al. Sci Total Environ. 2022 Feb 1;806(Pt 3):151275. doi: 10.1016/j.scitotenv.2021.151275. Epub 2021 Oct 28. Sci Total Environ. 2022. PMID: 34743888
., Hong Kong (HK), Guangzhou (GZ), Shanghai (SH), and Beijing (BJ)). The spatial coverage of three climatic zones from the south to the north in China is accompanied with a wide range of aerosol inorganic sulfate (4.9-13.8 mug/m(3)). ...The seasonal averages of the …
., Hong Kong (HK), Guangzhou (GZ), Shanghai (SH), and Beijing (BJ)). The spatial coverage of three climatic zones from the south to t …
Serological Biomarkers of Tissue Turnover Identify Responders to Anti-TNF Therapy in Crohn's Disease: A Pilot Study.
van Haaften WT, Mortensen JH, Dige AK, Grønbæk H, Hvas CL, Bay-Jensen AC, Karsdal MA, Olinga P, Manon-Jensen T, Dijkstra G. van Haaften WT, et al. Clin Transl Gastroenterol. 2020 Sep;11(9):e00217. doi: 10.14309/ctg.0000000000000217. Clin Transl Gastroenterol. 2020. PMID: 33094957 Free PMC article.
METHODS: In 2 retrospective observational cohorts, markers for matrix metalloproteinase-degraded type III and IV collagens (C3M and C4M, respectively) and for formation of type III and IV collagens (PRO-C3 and PRO-C4, respectively) were measured in serum and compared with …
METHODS: In 2 retrospective observational cohorts, markers for matrix metalloproteinase-degraded type III and IV collagens (C3M and C4M, res …
Complement Activation Levels Are Related to Disease Stage in AMD.
Heesterbeek TJ, Lechanteur YTE, Lorés-Motta L, Schick T, Daha MR, Altay L, Liakopoulos S, Smailhodzic D, den Hollander AI, Hoyng CB, de Jong EK, Klevering BJ. Heesterbeek TJ, et al. Invest Ophthalmol Vis Sci. 2020 Mar 9;61(3):18. doi: 10.1167/iovs.61.3.18. Invest Ophthalmol Vis Sci. 2020. PMID: 32176267 Free PMC article.
Differences in complement activation, as defined by the systemic C3d/C3 ratio, between AMD stages were evaluated using general linear modeling. ...RESULTS: Complement activation levels differed significantly between AMD disease stages. As compared with controls, the C3d/ …
Differences in complement activation, as defined by the systemic C3d/C3 ratio, between AMD stages were evaluated using general linear …
Conformational Landscapes and Infrared Spectra of Gas-phase Interstellar Molecular Clusters [(C3H3N)(CH3OH)n, n = 1-4].
Zhang Z, Nie W, Sun F, Zhang Y, Xie M, Hu Y. Zhang Z, et al. J Phys Chem A. 2020 Mar 26;124(12):2398-2407. doi: 10.1021/acs.jpca.9b11387. Epub 2020 Mar 13. J Phys Chem A. 2020. PMID: 32149507
Acrylonitrile (A) is one of the important interstellar molecules, which is considered closely related to the origin of life. And methanol (M) is one of the commonly used solvents, which is also found in outer space. ...Calculated IR spectra, which were predicted with the B …
Acrylonitrile (A) is one of the important interstellar molecules, which is considered closely related to the origin of life. And methanol ( …
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart A, Anderson K, Mainolfi N, Sellner H, Ehara T, Adams CM, Mac Sweeney A, Liao SM, Crowley M, Littlewood-Evans A, Sarret S, Wieczorek G, Perrot L, Dubost V, Flandre T, Zhang Y, Smith RJH, Risitano AM, Karki RG, Zhang C, Valeur E, Sirockin F, Gerhartz B, Erbel P, Hughes N, Smith TM, Cumin F, Argikar UA, Haraldsson B, Mogi M, Sedrani R, Wiesmann C, Jaffee B, Maibaum J, Flohr S, Harrison R, Eder J. Schubart A, et al. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931. doi: 10.1073/pnas.1820892116. Epub 2019 Mar 29. Proc Natl Acad Sci U S A. 2019. PMID: 30926668 Free PMC article.
Dysregulation of the alternative complement pathway (AP) predisposes individuals to a number of diseases including paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and C3 glomerulopathy. Moreover, glomerular Ig deposits can lead to complement-driven …
Dysregulation of the alternative complement pathway (AP) predisposes individuals to a number of diseases including paroxysmal nocturnal hemo …
69 results