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Fatty acids and beta-cell function.
Björklund A, Yaney G, McGarry JD, Weir G. Björklund A, et al. Diabetologia. 1997 Oct;40 Suppl 3:B21-6. doi: 10.1007/BF03168182. Diabetologia. 1997. PMID: 9345641 No abstract available.
Improved beta cell function after short-term treatment with diazoxide in obese subjects with type 2 diabetes.
Guldstrand M, Grill V, Björklund A, Lins PE, Adamson U. Guldstrand M, et al. Among authors: bjorklund a. Diabetes Metab. 2002 Dec;28(6 Pt 1):448-56. Diabetes Metab. 2002. PMID: 12522324 Clinical Trial.
Openers of ATP-dependent K+-channels protect against a signal-transduction-linked and not freely reversible defect of insulin secretion in a rat islet transplantation model of Type 2 diabetes.
Björklund A, Bondo Hansen J, Falkmer S, Grill V. Björklund A, et al. Diabetologia. 2004 May;47(5):885-91. doi: 10.1007/s00125-004-1386-7. Epub 2004 Apr 16. Diabetologia. 2004. PMID: 15088085
Glucose-induced [Ca2+]i abnormalities in human pancreatic islets: important role of overstimulation.
Björklund A, Lansner A, Grill VE. Björklund A, et al. Diabetes. 2000 Nov;49(11):1840-8. doi: 10.2337/diabetes.49.11.1840. Diabetes. 2000. PMID: 11078450
Relief from glucose-induced over-stimulation sensitizes the adenylate cyclase-cAMP system of rat pancreatic islets.
Björklund A, Grill VE. Björklund A, et al. J Endocrinol. 2000 Sep;166(3):537-44. doi: 10.1677/joe.0.1660537. J Endocrinol. 2000. PMID: 10974648
Enhancing effects of long-term elevated glucose and palmitate on stored and secreted proinsulin-to-insulin ratios in human pancreatic islets.
Björklund A, Grill V. Björklund A, et al. Diabetes. 1999 Jul;48(7):1409-14. doi: 10.2337/diabetes.48.7.1409. Diabetes. 1999. PMID: 10389846
B-cell insensitivity in vitro: reversal by diazoxide entails more than one event in stimulus-secretion coupling.
Björklund A, Grill V. Björklund A, et al. Endocrinology. 1993 Mar;132(3):1319-28. doi: 10.1210/endo.132.3.7679978. Endocrinology. 1993. PMID: 7679978
Evidence that insulin secretion influences SNAP-25 through proteasomal activation.
Ma Z, Portwood N, Foss A, Grill V, Björklund A. Ma Z, et al. Among authors: bjorklund a. Biochem Biophys Res Commun. 2005 Apr 15;329(3):1118-26. doi: 10.1016/j.bbrc.2005.02.086. Biochem Biophys Res Commun. 2005. PMID: 15752769
Diabetes reduces β-cell mitochondria and induces distinct morphological abnormalities, which are reproducible by high glucose in vitro with attendant dysfunction.
Ma Z, Wirström T, Borg LA, Larsson-Nyrén G, Hals I, Bondo-Hansen J, Grill V, Björklund A. Ma Z, et al. Among authors: bjorklund a. Islets. 2012 May-Jun;4(3):233-42. doi: 10.4161/isl.20516. Islets. 2012. PMID: 22854606 Free PMC article.
Facilitation of fatty acid uptake by CD36 in insulin-producing cells reduces fatty-acid-induced insulin secretion and glucose regulation of fatty acid oxidation.
Wallin T, Ma Z, Ogata H, Jørgensen IH, Iezzi M, Wang H, Wollheim CB, Björklund A. Wallin T, et al. Among authors: bjorklund a. Biochim Biophys Acta. 2010 Feb;1801(2):191-7. doi: 10.1016/j.bbalip.2009.11.002. Epub 2009 Nov 18. Biochim Biophys Acta. 2010. PMID: 19931418
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