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Ticagrelor inhibits adenosine uptake in vitro and enhances adenosine-mediated hyperemia responses in a canine model.
van Giezen JJ, Sidaway J, Glaves P, Kirk I, Björkman JA. van Giezen JJ, et al. Among authors: bjorkman ja. J Cardiovasc Pharmacol Ther. 2012 Jun;17(2):164-72. doi: 10.1177/1074248411410883. Epub 2011 Jun 22. J Cardiovasc Pharmacol Ther. 2012. PMID: 21697355
Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.
Bach P, Antonsson T, Bylund R, Björkman JA, Österlund K, Giordanetto F, van Giezen JJ, Andersen SM, Zachrisson H, Zetterberg F. Bach P, et al. Among authors: bjorkman ja. J Med Chem. 2013 Sep 12;56(17):7015-24. doi: 10.1021/jm400820m. Epub 2013 Aug 29. J Med Chem. 2013. PMID: 23899349
Optimization of ketone-based P2Y(12) receptor antagonists as antithrombotic agents: pharmacodynamics and receptor kinetics considerations.
Giordanetto F, Bach P, Zetterberg F, Antonsson T, Bylund R, Johansson J, Sellén M, Brown D, Hideståhl L, Berntsson P, Hovdal D, Zachrisson H, Björkman JA, van Giezen JJ. Giordanetto F, et al. Among authors: bjorkman ja. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2963-8. doi: 10.1016/j.bmcl.2014.04.001. Epub 2014 Apr 12. Bioorg Med Chem Lett. 2014. PMID: 24835983
Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis.
van Giezen JJ, Berntsson P, Zachrisson H, Björkman JA. van Giezen JJ, et al. Among authors: bjorkman ja. Thromb Res. 2009 Nov;124(5):565-71. doi: 10.1016/j.thromres.2009.06.029. Epub 2009 Aug 18. Thromb Res. 2009. PMID: 19692114
Usefulness of a nanoparticle formulation to investigate some hemodynamic parameters of a poorly soluble compound.
Sigfridsson K, Björkman JA, Skantze P, Zachrisson H. Sigfridsson K, et al. Among authors: bjorkman ja. J Pharm Sci. 2011 Jun;100(6):2194-202. doi: 10.1002/jps.22440. Epub 2010 Dec 22. J Pharm Sci. 2011. PMID: 21491443
High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition.
Björkman JA, Zachrisson H, Forsberg GB, von Bahr H, Hansson GI, Warner TD, Nylander S. Björkman JA, et al. Thromb Res. 2013 Apr;131(4):313-9. doi: 10.1016/j.thromres.2013.01.029. Epub 2013 Feb 15. Thromb Res. 2013. PMID: 23419412
Influence of endogenous neuropeptide Y (NPY) on the sympathetic-parasympathetic interaction in the canine heart.
Ilebekk A, Björkman JA, Nordlander M. Ilebekk A, et al. Among authors: bjorkman ja. J Cardiovasc Pharmacol. 2005 Oct;46(4):474-80. doi: 10.1097/01.fjc.0000177986.21929.d8. J Cardiovasc Pharmacol. 2005. PMID: 16160600
Cardiac sympathetic nerve stimulation triggers coronary t-PA release.
Björkman JA, Jern S, Jern C. Björkman JA, et al. Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):1091-7. doi: 10.1161/01.ATV.0000072966.23250.1E. Epub 2003 Apr 24. Arterioscler Thromb Vasc Biol. 2003. PMID: 12714432
Prevention of ventricular fibrillation requires central beta-adrenoceptor blockade in rabbits.
Ablad B, Bjurö T, Björkman JA, Edström T. Ablad B, et al. Among authors: bjorkman ja. Scand Cardiovasc J. 2007 Aug;41(4):221-9. doi: 10.1080/14017430701383748. Scand Cardiovasc J. 2007. PMID: 17680509 Clinical Trial.
Ventricular fibrillation induced by ischemia-reperfusion is not prevented by the NPY Y2 receptor antagonist BIIE0246.
Ilebekk A, Eriksen M, Sevre K, Aspelin T, Björkman JA, Lyberg T, Nordlander M. Ilebekk A, et al. Among authors: bjorkman ja. J Cardiovasc Pharmacol Ther. 2006 Sep;11(3):177-83. doi: 10.1177/1074248406292709. J Cardiovasc Pharmacol Ther. 2006. PMID: 17056830
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