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Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: a 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citizens.
Alehagen U, Johansson P, Björnstedt M, Rosén A, Dahlström U. Alehagen U, et al. Int J Cardiol. 2013 Sep 1;167(5):1860-6. doi: 10.1016/j.ijcard.2012.04.156. Epub 2012 May 23. Int J Cardiol. 2013. PMID: 22626835 Clinical Trial.
Relatively high mortality risk in elderly Swedish subjects with low selenium status.
Alehagen U, Johansson P, Björnstedt M, Rosén A, Post C, Aaseth J. Alehagen U, et al. Eur J Clin Nutr. 2016 Jan;70(1):91-6. doi: 10.1038/ejcn.2015.92. Epub 2015 Jun 24. Eur J Clin Nutr. 2016. PMID: 26105108 Free PMC article.
Selenium prevents tumor development in a rat model for chemical carcinogenesis.
Björkhem-Bergman L, Torndal UB, Eken S, Nyström C, Capitanio A, Larsen EH, Björnstedt M, Eriksson LC. Björkhem-Bergman L, et al. Carcinogenesis. 2005 Jan;26(1):125-31. doi: 10.1093/carcin/bgh290. Epub 2004 Sep 30. Carcinogenesis. 2005. PMID: 15459019
However, selenite treatment during the promotion phase decreased the volume fraction of pre-neoplastic liver nodules from 38% in control animals to 25 (1 p.p.m.) and 14% (5 p.p.m.) in the selenite-supplemented groups. In addition the cell proliferation within the no …
However, selenite treatment during the promotion phase decreased the volume fraction of pre-neoplastic liver nodules from 38% in control ani …
The role of thioredoxin reductase activity in selenium-induced cytotoxicity.
Madeja Z, Sroka J, Nyström C, Björkhem-Bergman L, Nordman T, Damdimopoulos A, Nalvarte I, Eriksson LC, Spyrou G, Olsson JM, Björnstedt M. Madeja Z, et al. Biochem Pharmacol. 2005 Jun 15;69(12):1765-72. doi: 10.1016/j.bcp.2005.02.023. Biochem Pharmacol. 2005. PMID: 15935149
Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity.
Wallenberg M, Olm E, Hebert C, Björnstedt M, Fernandes AP. Wallenberg M, et al. Biochem J. 2010 Jul 1;429(1):85-93. doi: 10.1042/BJ20100368. Biochem J. 2010. PMID: 20408818
Selenium in the prevention of human cancers.
Björnstedt M, Fernandes AP. Björnstedt M, et al. EPMA J. 2010 Sep;1(3):389-95. doi: 10.1007/s13167-010-0033-2. Epub 2010 Jun 29. EPMA J. 2010. PMID: 23199083 Free PMC article.
High risk of primary liver cancer in a cohort of 179 patients with Acute Hepatic Porphyria.
Sardh E, Wahlin S, Björnstedt M, Harper P, Andersson DE. Sardh E, et al. J Inherit Metab Dis. 2013 Nov;36(6):1063-71. doi: 10.1007/s10545-012-9576-9. Epub 2013 Jan 23. J Inherit Metab Dis. 2013. PMID: 23344888
Selenium induces a multi-targeted cell death process in addition to ROS formation.
Wallenberg M, Misra S, Wasik AM, Marzano C, Björnstedt M, Gandin V, Fernandes AP. Wallenberg M, et al. J Cell Mol Med. 2014 Apr;18(4):671-84. doi: 10.1111/jcmm.12214. Epub 2014 Jan 8. J Cell Mol Med. 2014. PMID: 24400844 Free PMC article.
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