Blättler WA - Search Results

1

Semisynthetic maytansine analogues for the targeted treatment of cancer.

Widdison WC, Wilhelm SD, Cavanagh EE, Whiteman KR, Leece BA, Kovtun Y, Goldmacher VS, Xie H, Steeves RM, Lutz RJ, Zhao R, Wang L, Blättler WA, Chari RV. Widdison WC, et al. Among authors: blattler wa. J Med Chem. 2006 Jul 13;49(14):4392-408. doi: 10.1021/jm060319f. J Med Chem. 2006. PMID: 16821799

2

Antibody-maytansinoid conjugates are activated in targeted cancer cells by lysosomal degradation and linker-dependent intracellular processing.

Erickson HK, Park PU, Widdison WC, Kovtun YV, Garrett LM, Hoffman K, Lutz RJ, Goldmacher VS, Blättler WA. Erickson HK, et al. Among authors: blattler wa. Cancer Res. 2006 Apr 15;66(8):4426-33. doi: 10.1158/0008-5472.CAN-05-4489. Cancer Res. 2006. PMID: 16618769

3

In vivo behaviour of antibody-drug conjugates for the targeted treatment of cancer.

Xie H, Blättler WA. Xie H, et al. Among authors: blattler wa. Expert Opin Biol Ther. 2006 Mar;6(3):281-91. doi: 10.1517/14712598.6.3.281. Expert Opin Biol Ther. 2006. PMID: 16503736 Review.

4

Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen.

Kovtun YV, Audette CA, Ye Y, Xie H, Ruberti MF, Phinney SJ, Leece BA, Chittenden T, Blättler WA, Goldmacher VS. Kovtun YV, et al. Among authors: blattler wa. Cancer Res. 2006 Mar 15;66(6):3214-21. doi: 10.1158/0008-5472.CAN-05-3973. Cancer Res. 2006. PMID: 16540673

5

Immunoconjugates containing novel maytansinoids: promising anticancer drugs.

Chari RV, Martell BA, Gross JL, Cook SB, Shah SA, Blättler WA, McKenzie SJ, Goldmacher VS. Chari RV, et al. Among authors: blattler wa. Cancer Res. 1992 Jan 1;52(1):127-31. Cancer Res. 1992. PMID: 1727373

6

Realizing the full potential of immunotoxins.

Blättler WA, Lambert JM, Goldmacher VS. Blättler WA, et al. Cancer Cells. 1989 Oct;1(2):50-5. Cancer Cells. 1989. PMID: 2701364 Review.

7

Eradication of large colon tumor xenografts by targeted delivery of maytansinoids.

Liu C, Tadayoni BM, Bourret LA, Mattocks KM, Derr SM, Widdison WC, Kedersha NL, Ariniello PD, Goldmacher VS, Lambert JM, Blättler WA, Chari RV. Liu C, et al. Among authors: blattler wa. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8618-23. doi: 10.1073/pnas.93.16.8618. Proc Natl Acad Sci U S A. 1996. PMID: 8710920 Free PMC article.

8

Photoactivation of toxin conjugates.

Goldmacher VS, Senter PD, Lambert JM, Blättler WA. Goldmacher VS, et al. Among authors: blattler wa. Bioconjug Chem. 1992 Mar-Apr;3(2):104-7. doi: 10.1021/bc00014a003. Bioconjug Chem. 1992. PMID: 1515463

9

The specific cytotoxicity of immunoconjugates containing blocked ricin is dependent on the residual binding capacity of blocked ricin: evidence that the membrane binding and A-chain translocation activities of ricin cannot be separated.

Goldmacher VS, Lambert JM, Blättler WA. Goldmacher VS, et al. Among authors: blattler wa. Biochem Biophys Res Commun. 1992 Mar 16;183(2):758-66. doi: 10.1016/0006-291x(92)90548-y. Biochem Biophys Res Commun. 1992. PMID: 1550582

10

The galactose-binding sites of the cytotoxic lectin ricin can be chemically blocked in high yield with reactive ligands prepared by chemical modification of glycopeptides containing triantennary N-linked oligosaccharides.

Lambert JM, McIntyre G, Gauthier MN, Zullo D, Rao V, Steeves RM, Goldmacher VS, Blättler WA. Lambert JM, et al. Among authors: blattler wa. Biochemistry. 1991 Apr 2;30(13):3234-47. doi: 10.1021/bi00227a011. Biochemistry. 1991. PMID: 1706936

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