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Sequestration shapes the response of signal transduction cascades.
Blüthgen N. Blüthgen N. IUBMB Life. 2006 Nov;58(11):659-63. doi: 10.1080/15216540600994340. IUBMB Life. 2006. PMID: 17085386 Review.
How robust are switches in intracellular signaling cascades?
Blüthgen N, Herzel H. Blüthgen N, et al. J Theor Biol. 2003 Dec 7;225(3):293-300. doi: 10.1016/s0022-5193(03)00247-9. J Theor Biol. 2003. PMID: 14604583
Effects of sequestration on signal transduction cascades.
Blüthgen N, Bruggeman FJ, Legewie S, Herzel H, Westerhoff HV, Kholodenko BN. Blüthgen N, et al. FEBS J. 2006 Mar;273(5):895-906. doi: 10.1111/j.1742-4658.2006.05105.x. FEBS J. 2006. PMID: 16478465
Competing docking interactions can bring about bistability in the MAPK cascade.
Legewie S, Schoeberl B, Blüthgen N, Herzel H. Legewie S, et al. Biophys J. 2007 Oct 1;93(7):2279-88. doi: 10.1529/biophysj.107.109132. Epub 2007 May 25. Biophys J. 2007. PMID: 17526574 Free PMC article.
Mathematical models in mammalian cell biology.
Herzel H, Blüthgen N. Herzel H, et al. Genome Biol. 2008;9(7):316. doi: 10.1186/gb-2008-9-7-316. Epub 2008 Jul 15. Genome Biol. 2008. PMID: 18638360 Free PMC article.
A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts.
Blüthgen N, Legewie S, Kielbasa SM, Schramme A, Tchernitsa O, Keil J, Solf A, Vingron M, Schäfer R, Herzel H, Sers C. Blüthgen N, et al. FEBS J. 2009 Feb;276(4):1024-35. doi: 10.1111/j.1742-4658.2008.06846.x. Epub 2009 Jan 12. FEBS J. 2009. PMID: 19154344
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