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Cell senescence: hypertrophic arrest beyond the restriction point.
Blagosklonny MV. Blagosklonny MV. J Cell Physiol. 2006 Dec;209(3):592-7. doi: 10.1002/jcp.20750. J Cell Physiol. 2006. PMID: 17001692 Review.
Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program).
Leontieva OV, Demidenko ZN, Blagosklonny MV. Leontieva OV, et al. Among authors: blagosklonny mv. Oncotarget. 2015 Sep 15;6(27):23238-48. doi: 10.18632/oncotarget.4836. Oncotarget. 2015. PMID: 26177051 Free PMC article.
Tumor promoter-induced cellular senescence: cell cycle arrest followed by geroconversion.
Leontieva OV, Blagosklonny MV. Leontieva OV, et al. Among authors: blagosklonny mv. Oncotarget. 2014 Dec 30;5(24):12715-27. doi: 10.18632/oncotarget.3011. Oncotarget. 2014. PMID: 25587030 Free PMC article.
Contact inhibition and high cell density deactivate the mammalian target of rapamycin pathway, thus suppressing the senescence program.
Leontieva OV, Demidenko ZN, Blagosklonny MV. Leontieva OV, et al. Among authors: blagosklonny mv. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8832-7. doi: 10.1073/pnas.1405723111. Epub 2014 Jun 2. Proc Natl Acad Sci U S A. 2014. PMID: 24889617 Free PMC article.
Hypoxia, MTOR and autophagy: converging on senescence or quiescence.
Blagosklonny MV. Blagosklonny MV. Autophagy. 2013 Feb 1;9(2):260-2. doi: 10.4161/auto.22783. Epub 2012 Nov 28. Autophagy. 2013. PMID: 23192222 Free PMC article.
Hypoxia suppresses conversion from proliferative arrest to cellular senescence.
Leontieva OV, Natarajan V, Demidenko ZN, Burdelya LG, Gudkov AV, Blagosklonny MV. Leontieva OV, et al. Among authors: blagosklonny mv. Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13314-8. doi: 10.1073/pnas.1205690109. Epub 2012 Jul 30. Proc Natl Acad Sci U S A. 2012. PMID: 22847439 Free PMC article.
Cell cycle arrest is not yet senescence, which is not just cell cycle arrest: terminology for TOR-driven aging.
Blagosklonny MV. Blagosklonny MV. Aging (Albany NY). 2012 Mar;4(3):159-65. doi: 10.18632/aging.100443. Aging (Albany NY). 2012. PMID: 22394614 Free PMC article.
Cell cycle arrest is not senescence.
Blagosklonny MV. Blagosklonny MV. Aging (Albany NY). 2011 Feb;3(2):94-101. doi: 10.18632/aging.100281. Aging (Albany NY). 2011. PMID: 21297220 Free PMC article. Review.
DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence.
Leontieva OV, Blagosklonny MV. Leontieva OV, et al. Among authors: blagosklonny mv. Aging (Albany NY). 2010 Dec;2(12):924-35. doi: 10.18632/aging.100265. Aging (Albany NY). 2010. PMID: 21212465 Free PMC article.
The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway.
Korotchkina LG, Leontieva OV, Bukreeva EI, Demidenko ZN, Gudkov AV, Blagosklonny MV. Korotchkina LG, et al. Among authors: blagosklonny mv. Aging (Albany NY). 2010 Jun;2(6):344-52. doi: 10.18632/aging.100160. Aging (Albany NY). 2010. PMID: 20606252 Free PMC article.
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