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Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design.
Alleyne C, Amin RP, Bhatt B, Bianchi E, Blain JC, Boyer N, Branca D, Embrey MW, Ha SN, Jette K, Johns DG, Kerekes AD, Koeplinger KA, LaPlaca D, Li N, Murphy B, Orth P, Ricardo A, Salowe S, Seyb K, Shahripour A, Stringer JR, Sun Y, Tracy R, Wu C, Xiong Y, Youm H, Zokian HJ, Tucker TJ. Alleyne C, et al. Among authors: blain jc. J Med Chem. 2020 Nov 25;63(22):13796-13824. doi: 10.1021/acs.jmedchem.0c01084. Epub 2020 Nov 10. J Med Chem. 2020. PMID: 33170686
PEARL-seq: A Photoaffinity Platform for the Analysis of Small Molecule-RNA Interactions.
Mukherjee H, Blain JC, Vandivier LE, Chin DN, Friedman JE, Liu F, Maillet A, Fang C, Kaplan JB, Li J, Chenoweth DM, Christensen AB, Petersen LK, Hansen NJV, Barrera L, Kubica N, Kumaravel G, Petter JC. Mukherjee H, et al. Among authors: blain jc. ACS Chem Biol. 2020 Sep 18;15(9):2374-2381. doi: 10.1021/acschembio.0c00357. Epub 2020 Aug 17. ACS Chem Biol. 2020. PMID: 32804474 Free article.
Uncovering the thermodynamics of monomer binding for RNA replication.
Izgu EC, Fahrenbach AC, Zhang N, Li L, Zhang W, Larsen AT, Blain JC, Szostak JW. Izgu EC, et al. Among authors: blain jc. J Am Chem Soc. 2015 May 20;137(19):6373-82. doi: 10.1021/jacs.5b02707. Epub 2015 May 7. J Am Chem Soc. 2015. PMID: 25901790 Free PMC article.
Progress toward synthetic cells.
Blain JC, Szostak JW. Blain JC, et al. Annu Rev Biochem. 2014;83:615-40. doi: 10.1146/annurev-biochem-080411-124036. Epub 2014 Mar 3. Annu Rev Biochem. 2014. PMID: 24606140 Review.
17 results