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Somatostatin inhibits insulin and glucagon secretion via two receptors subtypes: an in vitro study of pancreatic islets from somatostatin receptor 2 knockout mice.
Strowski MZ, Parmar RM, Blake AD, Schaeffer JM. Strowski MZ, et al. Endocrinology. 2000 Jan;141(1):111-7. doi: 10.1210/endo.141.1.7263. Endocrinology. 2000. PMID: 10614629
Somatostatin: a hormone for the heart?
Badway AC, Blake AD. Badway AC, et al. Among authors: blake ad. Curr Vasc Pharmacol. 2005 Apr;3(2):125-31. doi: 10.2174/1570161053586958. Curr Vasc Pharmacol. 2005. PMID: 15853632 Review.
Differential desensitization of somatostatin receptor subtypes in atT-20 cells.
Mazza FC, Blake AD. Mazza FC, et al. Among authors: blake ad. Protein Pept Lett. 2004 Apr;11(2):141-7. doi: 10.2174/0929866043478239. Protein Pept Lett. 2004. PMID: 15078202
Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.
Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM. Rohrer SP, et al. Science. 1998 Oct 23;282(5389):737-40. doi: 10.1126/science.282.5389.737. Science. 1998. PMID: 9784130
Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.
Ye Z, Gao Y, Bakshi RK, Chen MH, Rohrer SP, Feighner SD, Pong SS, Howard AD, Blake A, Birzin ET, Locco L, Parmar RM, Chan WW, Schaeffer JM, Smith RG, Patchett AA, Nargund RP. Ye Z, et al. Bioorg Med Chem Lett. 2000 Jan 3;10(1):5-8. doi: 10.1016/s0960-894x(99)00584-3. Bioorg Med Chem Lett. 2000. PMID: 10636230
Somatostatin increases voltage-gated K+ currents in GH3 cells through activation of multiple somatostatin receptors.
Yang SK, Parkington HC, Blake AD, Keating DJ, Chen C. Yang SK, et al. Among authors: blake ad. Endocrinology. 2005 Nov;146(11):4975-84. doi: 10.1210/en.2005-0696. Epub 2005 Aug 4. Endocrinology. 2005. PMID: 16081634
Somatostatin receptor subtypes 2 and 5 inhibit corticotropin-releasing hormone-stimulated adrenocorticotropin secretion from AtT-20 cells.
Strowski MZ, Dashkevicz MP, Parmar RM, Wilkinson H, Kohler M, Schaeffer JM, Blake AD. Strowski MZ, et al. Neuroendocrinology. 2002 Jun;75(6):339-46. doi: 10.1159/000059430. Neuroendocrinology. 2002. PMID: 12065886
Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis.
Strowski MZ, Kohler M, Chen HY, Trumbauer ME, Li Z, Szalkowski D, Gopal-Truter S, Fisher JK, Schaeffer JM, Blake AD, Zhang BB, Wilkinson HA. Strowski MZ, et al. Mol Endocrinol. 2003 Jan;17(1):93-106. doi: 10.1210/me.2001-0035. Mol Endocrinol. 2003. PMID: 12511609
Function and expression of somatostatin receptors of the endocrine pancreas.
Strowski MZ, Blake AD. Strowski MZ, et al. Among authors: blake ad. Mol Cell Endocrinol. 2008 May 14;286(1-2):169-79. doi: 10.1016/j.mce.2008.02.007. Epub 2008 Feb 17. Mol Cell Endocrinol. 2008. PMID: 18375050 Review.
Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from rat anterior pituitary cells.
Parmar RM, Chan WW, Dashkevicz M, Hayes EC, Rohrer SP, Smith RG, Schaeffer JM, Blake AD. Parmar RM, et al. Biochem Biophys Res Commun. 1999 Sep 24;263(2):276-80. doi: 10.1006/bbrc.1999.1376. Biochem Biophys Res Commun. 1999. PMID: 10491284
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