Blake AD - Search Results

1

Ligand binding to the beta-adrenergic receptor involves its rhodopsin-like core.

Dixon RA, Sigal IS, Rands E, Register RB, Candelore MR, Blake AD, Strader CD. Dixon RA, et al. Among authors: blake ad. Nature. 1987 Mar 5-11;326(6108):73-7. doi: 10.1038/326073a0. Nature. 1987. PMID: 2881211

2

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

Strader CD, Dixon RA, Cheung AH, Candelore MR, Blake AD, Sigal IS. Strader CD, et al. Among authors: blake ad. J Biol Chem. 1987 Dec 5;262(34):16439-43. J Biol Chem. 1987. PMID: 2890637

3

The carboxyl terminus of the hamster beta-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration.

Strader CD, Sigal IS, Blake AD, Cheung AH, Register RB, Rands E, Zemcik BA, Candelore MR, Dixon RA. Strader CD, et al. Among authors: blake ad. Cell. 1987 Jun 19;49(6):855-63. doi: 10.1016/0092-8674(87)90623-4. Cell. 1987. PMID: 3034435

4

Mutagenesis of a single amino acid in the rat mu-opioid receptor discriminates ligand binding.

Bot G, Blake AD, Li S, Reisine T. Bot G, et al. Among authors: blake ad. J Neurochem. 1998 Jan;70(1):358-65. doi: 10.1046/j.1471-4159.1998.70010358.x. J Neurochem. 1998. PMID: 9422382

5

Synthetic segments of the mammalian beta AR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C.

Blake AD, Mumford RA, Strout HV, Slater EE, Strader CD. Blake AD, et al. Biochem Biophys Res Commun. 1987 Aug 31;147(1):168-73. doi: 10.1016/s0006-291x(87)80102-x. Biochem Biophys Res Commun. 1987. PMID: 2820394

6

Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry.

Rohrer SP, Birzin ET, Mosley RT, Berk SC, Hutchins SM, Shen DM, Xiong Y, Hayes EC, Parmar RM, Foor F, Mitra SW, Degrado SJ, Shu M, Klopp JM, Cai SJ, Blake A, Chan WW, Pasternak A, Yang L, Patchett AA, Smith RG, Chapman KT, Schaeffer JM. Rohrer SP, et al. Science. 1998 Oct 23;282(5389):737-40. doi: 10.1126/science.282.5389.737. Science. 1998. PMID: 9784130

7

Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues.

Ye Z, Gao Y, Bakshi RK, Chen MH, Rohrer SP, Feighner SD, Pong SS, Howard AD, Blake A, Birzin ET, Locco L, Parmar RM, Chan WW, Schaeffer JM, Smith RG, Patchett AA, Nargund RP. Ye Z, et al. Among authors: blake a. Bioorg Med Chem Lett. 2000 Jan 3;10(1):5-8. doi: 10.1016/s0960-894x(99)00584-3. Bioorg Med Chem Lett. 2000. PMID: 10636230

8

Insulin receptor desensitization correlates with attenuation of tyrosine kinase activity, but not of receptor endocytosis.

Blake AD, Hayes NS, Slater EE, Strader CD. Blake AD, et al. Biochem J. 1987 Jul 15;245(2):357-64. doi: 10.1042/bj2450357. Biochem J. 1987. PMID: 3311033 Free PMC article.

9

The CXCR4 agonist ligand stromal derived factor-1 maintains high affinity for receptors in both Galpha(i)-coupled and uncoupled states.

Di Salvo J, Koch GE, Johnson KE, Blake AD, Daugherty BL, DeMartino JA, Sirotina-Meisher A, Liu Y, Springer MS, Cascieri MA, Sullivan KA. Di Salvo J, et al. Among authors: blake ad. Eur J Pharmacol. 2000 Dec 8;409(2):143-54. doi: 10.1016/s0014-2999(00)00846-3. Eur J Pharmacol. 2000. PMID: 11104827

10

Nonpeptidyl somatostatin agonists demonstrate that sst2 and sst5 inhibit stimulated growth hormone secretion from rat anterior pituitary cells.

Parmar RM, Chan WW, Dashkevicz M, Hayes EC, Rohrer SP, Smith RG, Schaeffer JM, Blake AD. Parmar RM, et al. Among authors: blake ad. Biochem Biophys Res Commun. 1999 Sep 24;263(2):276-80. doi: 10.1006/bbrc.1999.1376. Biochem Biophys Res Commun. 1999. PMID: 10491284

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