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Overexpression of components of the Frizzled-Dishevelled cascade results in apoptotic cell death, mediated by beta-catenin.
van Gijn ME, Snel F, Cleutjens JP, Smits JF, Blankesteijn WM. van Gijn ME, et al. Among authors: blankesteijn wm. Exp Cell Res. 2001 Apr 15;265(1):46-53. doi: 10.1006/excr.2001.5174. Exp Cell Res. 2001. PMID: 11281642
Increased expression of a homologue of drosophila tissue polarity gene "frizzled" in left ventricular hypertrophy in the rat, as identified by subtractive hybridization.
Blankesteijn WM, Essers-Janssen YP, Ulrich MM, Smits JF. Blankesteijn WM, et al. J Mol Cell Cardiol. 1996 May;28(5):1187-91. doi: 10.1006/jmcc.1996.0109. J Mol Cell Cardiol. 1996. PMID: 8762054
A homologue of Drosophila tissue polarity gene frizzled is expressed in migrating myofibroblasts in the infarcted rat heart.
Blankesteijn WM, Essers-Janssen YP, Verluyten MJ, Daemen MJ, Smits JF. Blankesteijn WM, et al. Nat Med. 1997 May;3(5):541-4. doi: 10.1038/nm0597-541. Nat Med. 1997. PMID: 9142123
Beta-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction.
Blankesteijn WM, van Gijn ME, Essers-Janssen YP, Daemen MJ, Smits JF. Blankesteijn WM, et al. Am J Pathol. 2000 Sep;157(3):877-83. doi: 10.1016/s0002-9440(10)64601-9. Am J Pathol. 2000. PMID: 10980127 Free PMC article.
Frizzled 2 is transiently expressed in neural crest-containing areas during development of the heart and great arteries in the mouse.
van Gijn ME, Blankesteijn WM, Smits JF, Hierck B, Gittenberger-de Groot AC. van Gijn ME, et al. Among authors: blankesteijn wm. Anat Embryol (Berl). 2001 Mar;203(3):185-92. doi: 10.1007/s004290000152. Anat Embryol (Berl). 2001. PMID: 11303904
Dynamics of cardiac wound healing following myocardial infarction: observations in genetically altered mice.
Blankesteijn WM, Creemers E, Lutgens E, Cleutjens JP, Daemen MJ, Smits JF. Blankesteijn WM, et al. Acta Physiol Scand. 2001 Sep;173(1):75-82. doi: 10.1046/j.1365-201X.2001.00887.x. Acta Physiol Scand. 2001. PMID: 11678729 Review.
A role for the beta-catenin/T-cell factor signaling cascade in vascular remodeling.
Wang X, Xiao Y, Mou Y, Zhao Y, Blankesteijn WM, Hall JL. Wang X, et al. Among authors: blankesteijn wm. Circ Res. 2002 Feb 22;90(3):340-7. doi: 10.1161/hh0302.104466. Circ Res. 2002. PMID: 11861424
The wnt-frizzled cascade in cardiovascular disease.
van Gijn ME, Daemen MJ, Smits JF, Blankesteijn WM. van Gijn ME, et al. Among authors: blankesteijn wm. Cardiovasc Res. 2002 Jul;55(1):16-24. doi: 10.1016/s0008-6363(02)00221-3. Cardiovasc Res. 2002. PMID: 12062705 Review. No abstract available.
Long-term structural and functional consequences of cardiac ischaemia-reperfusion injury in vivo in mice.
De Celle T, Cleutjens JP, Blankesteijn WM, Debets JJ, Smits JF, Janssen BJ. De Celle T, et al. Among authors: blankesteijn wm. Exp Physiol. 2004 Sep;89(5):605-15. doi: 10.1113/expphysiol.2004.027649. Epub 2004 Jul 15. Exp Physiol. 2004. PMID: 15258119
Thrombospondin-2 is essential for myocardial matrix integrity: increased expression identifies failure-prone cardiac hypertrophy.
Schroen B, Heymans S, Sharma U, Blankesteijn WM, Pokharel S, Cleutjens JP, Porter JG, Evelo CT, Duisters R, van Leeuwen RE, Janssen BJ, Debets JJ, Smits JF, Daemen MJ, Crijns HJ, Bornstein P, Pinto YM. Schroen B, et al. Among authors: blankesteijn wm. Circ Res. 2004 Sep 3;95(5):515-22. doi: 10.1161/01.RES.0000141019.20332.3e. Epub 2004 Jul 29. Circ Res. 2004. PMID: 15284191
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