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92 results
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Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics.
Usman N, Blatt LM. Usman N, et al. Among authors: blatt lm. J Clin Invest. 2000 Nov;106(10):1197-202. doi: 10.1172/JCI11631. J Clin Invest. 2000. PMID: 11086019 Free PMC article. Review. No abstract available.
Characterization of nuclease-resistant ribozymes directed against hepatitis B virus RNA.
Morrissey DV, Lee PA, Johnson DA, Overly SL, McSwiggen JA, Beigelman L, Mokler VR, Maloney L, Vargeese C, Bowman K, O'Brien JT, Shaffer CS, Conrad A, Schmid P, Morrey JD, Macejak DG, Pavco PA, Blatt LM. Morrissey DV, et al. Among authors: blatt lm. J Viral Hepat. 2002 Nov;9(6):411-8. doi: 10.1046/j.1365-2893.2002.00383.x. J Viral Hepat. 2002. PMID: 12431202
Enhanced antiviral effect in cell culture of type 1 interferon and ribozymes targeting HCV RNA.
Macejak DG, Jensen KL, Pavco PA, Phipps KM, Heinz BA, Colacino JM, Blatt LM. Macejak DG, et al. Among authors: blatt lm. J Viral Hepat. 2001 Nov;8(6):400-5. doi: 10.1046/j.1365-2893.2001.00321.x. J Viral Hepat. 2001. PMID: 11703570
Pharmacokinetics and tolerability of an antiangiogenic ribozyme (ANGIOZYME) in healthy volunteers.
Sandberg JA, Parker VP, Blanchard KS, Sweedler D, Powell JA, Kachensky A, Bellon L, Usman N, Rossing T, Borden E, Blatt LM. Sandberg JA, et al. Among authors: blatt lm. J Clin Pharmacol. 2000 Dec;40(12 Pt 2):1462-9. J Clin Pharmacol. 2000. PMID: 11185667 Clinical Trial.
Acute toxicology and pharmacokinetic assessment of a ribozyme (ANGIOZYME) targeting vascular endothelial growth factor receptor mRNA in the cynomolgus monkey.
Sandberg JA, Sproul CD, Blanchard KS, Bellon L, Sweedler D, Powell JA, Caputo FA, Kornbrust DJ, Parker VP, Parry TJ, Blatt LM. Sandberg JA, et al. Among authors: blatt lm. Antisense Nucleic Acid Drug Dev. 2000 Jun;10(3):153-62. doi: 10.1089/oli.1.2000.10.153. Antisense Nucleic Acid Drug Dev. 2000. PMID: 10905552
Pharmacokinetics and tissue distribution of a ribozyme directed against hepatitis C virus RNA following subcutaneous or intravenous administration in mice.
Lee PA, Blatt LM, Blanchard KS, Bouhana KS, Pavco PA, Bellon L, Sandberg JA. Lee PA, et al. Among authors: blatt lm. Hepatology. 2000 Sep;32(3):640-6. doi: 10.1053/jhep.2000.16599. Hepatology. 2000. PMID: 10960462
Monitoring post-translational modification of proteins with allosteric ribozymes.
Vaish NK, Dong F, Andrews L, Schweppe RE, Ahn NG, Blatt L, Seiwert SD. Vaish NK, et al. Nat Biotechnol. 2002 Aug;20(8):810-5. doi: 10.1038/nbt719. Epub 2002 Jul 15. Nat Biotechnol. 2002. PMID: 12118241
Inhibition of hepatitis C virus (HCV)-RNA-dependent translation and replication of a chimeric HCV poliovirus using synthetic stabilized ribozymes.
Macejak DG, Jensen KL, Jamison SF, Domenico K, Roberts EC, Chaudhary N, von Carlowitz I, Bellon L, Tong MJ, Conrad A, Pavco PA, Blatt LM. Macejak DG, et al. Among authors: blatt lm. Hepatology. 2000 Mar;31(3):769-76. doi: 10.1002/hep.510310331. Hepatology. 2000. PMID: 10706571
Short-Duration AL-335, Odalasvir, With or Without Simeprevir, in Patients With HCV GT1 or 3 Infection Without Cirrhosis.
Gane EJ, Stedman CA, Schwabe C, Vijgen L, Chanda S, Kakuda TN, Fry J, Blatt LM, McClure MW. Gane EJ, et al. Among authors: blatt lm. Hepatology. 2018 Dec;68(6):2145-2157. doi: 10.1002/hep.30126. Epub 2018 Nov 19. Hepatology. 2018. PMID: 30070722 Clinical Trial.
Final results of a double-blind, placebo-controlled trial of the antifibrotic efficacy of interferon-gamma1b in chronic hepatitis C patients with advanced fibrosis or cirrhosis.
Pockros PJ, Jeffers L, Afdhal N, Goodman ZD, Nelson D, Gish RG, Reddy KR, Reindollar R, Rodriguez-Torres M, Sullivan S, Blatt LM, Faris-Young S. Pockros PJ, et al. Among authors: blatt lm. Hepatology. 2007 Mar;45(3):569-78. doi: 10.1002/hep.21561. Hepatology. 2007. PMID: 17326152 Clinical Trial.
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