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A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML.
Mol Pharm. 2013 Nov 4;10(11):4358-66. doi: 10.1021/mp400458u. Epub 2013 Sep 30.
Mol Pharm. 2013.
PMID: 24079514
Free PMC article.
Ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017): a novel scaffold that resensitizes multidrug resistant leukemia cells to chemotherapy.
Das SG, Hermanson DL, Bleeker N, Lowman X, Li Y, Kelekar A, Xing C.
Das SG, et al.
ACS Chem Biol. 2013 Feb 15;8(2):327-35. doi: 10.1021/cb300460f. Epub 2012 Nov 5.
ACS Chem Biol. 2013.
PMID: 23102022
Free PMC article.
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Structure-activity relationship (SAR) study of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the potential of the lead against multidrug resistance in cancer treatment.
Aridoss G, Zhou B, Hermanson DL, Bleeker NP, Xing C.
Aridoss G, et al. Among authors: bleeker np.
J Med Chem. 2012 Jun 14;55(11):5566-81. doi: 10.1021/jm300515q. Epub 2012 May 23.
J Med Chem. 2012.
PMID: 22582991
Free PMC article.
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Structure-activity relationship and molecular mechanisms of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and its analogues.
Das SG, Srinivasan B, Hermanson DL, Bleeker NP, Doshi JM, Tang R, Beck WT, Xing C.
Das SG, et al. Among authors: bleeker np.
J Med Chem. 2011 Aug 25;54(16):5937-48. doi: 10.1021/jm200764t. Epub 2011 Aug 3.
J Med Chem. 2011.
PMID: 21780800
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Synthesis and evaluation of the anti-proliferative and NF-κB activities of a library of simplified tylophorine analogs.
Niphakis MJ, Gay BC, Hong KH, Bleeker NP, Georg GI.
Niphakis MJ, et al. Among authors: bleeker np.
Bioorg Med Chem. 2012 Oct 1;20(19):5893-900. doi: 10.1016/j.bmc.2012.07.044. Epub 2012 Aug 3.
Bioorg Med Chem. 2012.
PMID: 22910225
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