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Flupirtine shows functional NMDA receptor antagonism by enhancing Mg2+ block via activation of voltage independent potassium channels. Rapid communication.
Kornhuber J, Bleich S, Wiltfang J, Maler M, Parsons CG. Kornhuber J, et al. Among authors: Bleich S. J Neural Transm (Vienna). 1999;106(9-10):857-67. doi: 10.1007/s007020050206. J Neural Transm (Vienna). 1999. PMID: 10599868
The objective of the present study was to develop a plausible model to explain flupirtine's spectrum of action. A four-stage strategy was selected for this purpose: Firstly, the serum concentration of flupirtine under therapeutic conditions was determined on the basis of the current literature. ...The model presented here reconciles the known functional NMDA receptor antagonism of flupirtine with the activation of K+ channels that occurs at therapeutic concentrations, thus providing an understanding of flupirtine's spectrum of action. ...
The objective of the present study was to develop a plausible model to explain flupirtine's spectrum of action. A four-stage strategy …
[Neuronal potassium channel opening with flupirtine].
Kornhuber J, Maler M, Wiltfang J, Bleich S, Degner D, Rüther E. Kornhuber J, et al. Among authors: Bleich S. Fortschr Neurol Psychiatr. 1999 Oct;67(10):466-75. doi: 10.1055/s-2007-994997. Fortschr Neurol Psychiatr. 1999. PMID: 10596368 Review. German.
The substance's mechanism of action has yet to be fully explained. Over the past few years, however, evidence has accumulated that flupirtine interacts with the glutamatergic N-Methyl-D-Aspartate (NMDA) receptor. ...
The substance's mechanism of action has yet to be fully explained. Over the past few years, however, evidence has accumulated that fl …
CPAP-therapy effectively lowers serum homocysteine in obstructive sleep apnea syndrome.
Jordan W, Berger C, Cohrs S, Rodenbeck A, Mayer G, Niedmann PD, von Ahsen N, Rüther E, Kornhuber J, Bleich S. Jordan W, et al. Among authors: Bleich S. J Neural Transm (Vienna). 2004 Jun;111(6):683-9. doi: 10.1007/s00702-004-0130-2. J Neural Transm (Vienna). 2004. PMID: 15168215
Blue light improves cognitive performance.
Lehrl S, Gerstmeyer K, Jacob JH, Frieling H, Henkel AW, Meyrer R, Wiltfang J, Kornhuber J, Bleich S. Lehrl S, et al. Among authors: Bleich S. J Neural Transm (Vienna). 2007;114(4):457-60. doi: 10.1007/s00702-006-0621-4. Epub 2007 Jan 25. J Neural Transm (Vienna). 2007. PMID: 17245536
Memantine fails to facilitate partial cigarette deprivation in smokers--no role of Memantine in the treatment of nicotine dependency?
Thuerauf N, Lunkenheimer J, Lunkenheimer B, Sperling W, Bleich S, Schlabeck M, Wiltfang J, Kornhuber J. Thuerauf N, et al. Among authors: Bleich S. J Neural Transm (Vienna). 2007 Mar;114(3):351-7. doi: 10.1007/s00702-006-0570-y. Epub 2006 Oct 18. J Neural Transm (Vienna). 2007. PMID: 17043926 Clinical Trial.
Homocysteine levels in aqueous humor and plasma of patients with primary open-angle glaucoma.
Roedl JB, Bleich S, Reulbach U, von Ahsen N, Schlötzer-Schrehardt U, Rejdak R, Naumann GO, Kruse FE, Kornhuber J, Jünemann AG. Roedl JB, et al. Among authors: Bleich S. J Neural Transm (Vienna). 2007;114(4):445-50. doi: 10.1007/s00702-006-0556-9. Epub 2006 Aug 24. J Neural Transm (Vienna). 2007. PMID: 16932990
Biological markers to predict previous alcohol withdrawal seizures: a risk assessment.
Hillemacher T, Frieling H, Bayerlein K, Wilhelm J, Kornhuber J, Bleich S. Hillemacher T, et al. Among authors: Bleich S. J Neural Transm (Vienna). 2007 Feb;114(2):151-4. doi: 10.1007/s00702-006-0541-3. Epub 2006 Aug 10. J Neural Transm (Vienna). 2007. PMID: 16897604
Pearson's chi(2)-test showed significant results for the combined assessment of both parameters (chi(2) = 14.71, p = 0.001). ...
Pearson's chi(2)-test showed significant results for the combined assessment of both parameters (chi(2) = 14.71, p = 0.001). ...
Cognitive impairment and its association with homocysteine plasma levels in females with eating disorders - findings from the HEaD-study.
Frieling H, Röschke B, Kornhuber J, Wilhelm J, Römer KD, Gruss B, Bönsch D, Hillemacher T, de Zwaan M, Jacoby GE, Bleich S. Frieling H, et al. Among authors: Bleich S. J Neural Transm (Vienna). 2005 Nov;112(11):1591-8. doi: 10.1007/s00702-005-0392-3. J Neural Transm (Vienna). 2005. PMID: 16245072
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