Block M - Search Results

1

Physiologically based pharmacokinetic and pharmacodynamic modeling in cancer drug development: status, potential and gaps.

Block M. Block M. Expert Opin Drug Metab Toxicol. 2015 May;11(5):743-56. doi: 10.1517/17425255.2015.1037276. Expert Opin Drug Metab Toxicol. 2015. PMID: 25940026 Review.

2

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model.

Kuepfer L, Niederalt C, Wendl T, Schlender JF, Willmann S, Lippert J, Block M, Eissing T, Teutonico D. Kuepfer L, et al. Among authors: block m. CPT Pharmacometrics Syst Pharmacol. 2016 Oct;5(10):516-531. doi: 10.1002/psp4.12134. Epub 2016 Oct 19. CPT Pharmacometrics Syst Pharmacol. 2016. PMID: 27653238 Free PMC article.

3

Development of Physiologically Based Organ Models to Evaluate the Pharmacokinetics of Drugs in the Testes and the Thyroid Gland.

Pilari S, Gaub T, Block M, Görlitz L. Pilari S, et al. Among authors: block m. CPT Pharmacometrics Syst Pharmacol. 2017 Aug;6(8):532-542. doi: 10.1002/psp4.12205. Epub 2017 Jul 29. CPT Pharmacometrics Syst Pharmacol. 2017. PMID: 28571120 Free PMC article.

4

Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives.

Lahoz-Beneytez J, Elemans M, Zhang Y, Ahmed R, Salam A, Block M, Niederalt C, Asquith B, Macallan D. Lahoz-Beneytez J, et al. Among authors: block m. Blood. 2016 Jun 30;127(26):3431-8. doi: 10.1182/blood-2016-03-700336. Epub 2016 May 2. Blood. 2016. PMID: 27136946 Free PMC article.

5

Addressing Adherence Using Genotype-Specific PBPK Modeling-Impact of Drug Holidays on Tamoxifen and Endoxifen Plasma Levels.

Dickschen KJ, Willmann S, Hempel G, Block M. Dickschen KJ, et al. Among authors: block m. Front Pharmacol. 2017 Mar 14;8:67. doi: 10.3389/fphar.2017.00067. eCollection 2017. Front Pharmacol. 2017. PMID: 28382001 Free PMC article.

6

A generic whole body physiologically based pharmacokinetic model for therapeutic proteins in PK-Sim.

Niederalt C, Kuepfer L, Solodenko J, Eissing T, Siegmund HU, Block M, Willmann S, Lippert J. Niederalt C, et al. Among authors: block m. J Pharmacokinet Pharmacodyn. 2018 Apr;45(2):235-257. doi: 10.1007/s10928-017-9559-4. Epub 2017 Dec 12. J Pharmacokinet Pharmacodyn. 2018. PMID: 29234936 Free PMC article.

7

Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.

Krauss M, Hofmann U, Schafmayer C, Igel S, Schlender J, Mueller C, Brosch M, von Schoenfels W, Erhart W, Schuppert A, Block M, Schaeffeler E, Boehmer G, Goerlitz L, Hoecker J, Lippert J, Kerb R, Hampe J, Kuepfer L, Schwab M. Krauss M, et al. Among authors: block m. NPJ Syst Biol Appl. 2017 Mar 28;3:11. doi: 10.1038/s41540-017-0012-5. eCollection 2017. NPJ Syst Biol Appl. 2017. PMID: 28649438 Free PMC article.

8

A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.

Eissing T, Kuepfer L, Becker C, Block M, Coboeken K, Gaub T, Goerlitz L, Jaeger J, Loosen R, Ludewig B, Meyer M, Niederalt C, Sevestre M, Siegmund HU, Solodenko J, Thelen K, Telle U, Weiss W, Wendl T, Willmann S, Lippert J. Eissing T, et al. Among authors: block m. Front Physiol. 2011 Feb 24;2:4. doi: 10.3389/fphys.2011.00004. eCollection 2011. Front Physiol. 2011. PMID: 21483730 Free PMC article.

9

A detailed physiologically based model to simulate the pharmacokinetics and hormonal pharmacodynamics of enalapril on the circulating endocrine Renin-Angiotensin-aldosterone system.

Claassen K, Willmann S, Eissing T, Preusser T, Block M. Claassen K, et al. Among authors: block m. Front Physiol. 2013 Feb 8;4:4. doi: 10.3389/fphys.2013.00004. eCollection 2013. Front Physiol. 2013. PMID: 23404365 Free PMC article.

10

Evidence-Based Criteria for an Ideal Abutment Implant Connection-A Narrative Review.

Block MS. Block MS. J Oral Maxillofac Surg. 2022 Jul 7:S0278-2391(22)00506-7. doi: 10.1016/j.joms.2022.07.002. Online ahead of print. J Oral Maxillofac Surg. 2022. PMID: 35932894 Review.

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