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Amyloid-β and tau: the trigger and bullet in Alzheimer disease pathogenesis.
Bloom GS. Bloom GS. JAMA Neurol. 2014 Apr;71(4):505-8. doi: 10.1001/jamaneurol.2013.5847. JAMA Neurol. 2014. PMID: 24493463 Review.
Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons.
Khan SS, LaCroix M, Boyle G, Sherman MA, Brown JL, Amar F, Aldaco J, Lee MK, Bloom GS, Lesné SE. Khan SS, et al. Among authors: bloom gs. Acta Neuropathol. 2018 Oct;136(4):589-605. doi: 10.1007/s00401-018-1886-z. Epub 2018 Jul 11. Acta Neuropathol. 2018. PMID: 29995210 Free PMC article.
N-methyl-D-aspartate receptor-mediated calcium influx connects amyloid-β oligomers to ectopic neuronal cell cycle reentry in Alzheimer's disease.
Kodis EJ, Choi S, Swanson E, Ferreira G, Bloom GS. Kodis EJ, et al. Among authors: bloom gs. Alzheimers Dement. 2018 Oct;14(10):1302-1312. doi: 10.1016/j.jalz.2018.05.017. Epub 2018 Jul 4. Alzheimers Dement. 2018. PMID: 30293574
Aberrant Neuronal Cell Cycle Re-Entry: The Pathological Confluence of Alzheimer's Disease and Brain Insulin Resistance, and Its Relation to Cancer.
Koseoglu MM, Norambuena A, Sharlow ER, Lazo JS, Bloom GS. Koseoglu MM, et al. Among authors: bloom gs. J Alzheimers Dis. 2019;67(1):1-11. doi: 10.3233/JAD-180874. J Alzheimers Dis. 2019. PMID: 30452418 Review.
A novel lysosome-to-mitochondria signaling pathway disrupted by amyloid-β oligomers.
Norambuena A, Wallrabe H, Cao R, Wang DB, Silva A, Svindrych Z, Periasamy A, Hu S, Tanzi RE, Kim DY, Bloom GS. Norambuena A, et al. Among authors: bloom gs. EMBO J. 2018 Nov 15;37(22):e100241. doi: 10.15252/embj.2018100241. Epub 2018 Oct 22. EMBO J. 2018. PMID: 30348864 Free PMC article.
Extracellular Tau Oligomers Induce Invasion of Endogenous Tau into the Somatodendritic Compartment and Axonal Transport Dysfunction.
Swanson E, Breckenridge L, McMahon L, Som S, McConnell I, Bloom GS. Swanson E, et al. Among authors: bloom gs. J Alzheimers Dis. 2017;58(3):803-820. doi: 10.3233/JAD-170168. J Alzheimers Dis. 2017. PMID: 28482642 Free PMC article.
Reduced brain insulin signaling: A seminal process in Alzheimer's disease pathogenesis.
Bloom GS, Lazo JS, Norambuena A. Bloom GS, et al. Neuropharmacology. 2018 Jul 1;136(Pt B):192-195. doi: 10.1016/j.neuropharm.2017.09.016. Epub 2017 Sep 29. Neuropharmacology. 2018. PMID: 28965829 Free PMC article. Review.
mTOR and neuronal cell cycle reentry: How impaired brain insulin signaling promotes Alzheimer's disease.
Norambuena A, Wallrabe H, McMahon L, Silva A, Swanson E, Khan SS, Baerthlein D, Kodis E, Oddo S, Mandell JW, Bloom GS. Norambuena A, et al. Among authors: bloom gs. Alzheimers Dement. 2017 Feb;13(2):152-167. doi: 10.1016/j.jalz.2016.08.015. Epub 2016 Sep 29. Alzheimers Dement. 2017. PMID: 27693185 Free PMC article.
Tau: The Center of a Signaling Nexus in Alzheimer's Disease.
Khan SS, Bloom GS. Khan SS, et al. Among authors: bloom gs. Front Neurosci. 2016 Feb 9;10:31. doi: 10.3389/fnins.2016.00031. eCollection 2016. Front Neurosci. 2016. PMID: 26903798 Free PMC article. Review.
Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's disease.
Seward ME, Swanson E, Norambuena A, Reimann A, Cochran JN, Li R, Roberson ED, Bloom GS. Seward ME, et al. Among authors: bloom gs. J Cell Sci. 2013 Mar 1;126(Pt 5):1278-86. doi: 10.1242/jcs.1125880. Epub 2013 Jan 23. J Cell Sci. 2013. PMID: 23345405 Free PMC article.
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