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Ready, set, cleave: proteases in action.

Salpeter SJ, Blum G. Salpeter SJ, et al. Among authors: blum g. Chem Biol. 2013 Feb 21;20(2):137-8. doi: 10.1016/j.chembiol.2013.02.004. Chem Biol. 2013. PMID: 23438739

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Development of new insulin-like growth factor-1 receptor kinase inhibitors using catechol mimics.

Blum G, Gazit A, Levitzki A. Blum G, et al. J Biol Chem. 2003 Oct 17;278(42):40442-54. doi: 10.1074/jbc.M305490200. Epub 2003 Jul 16. J Biol Chem. 2003. PMID: 12869569

AG 538 is a substrate-competitive inhibitor of the IGF-1 receptor (IGF-1R), with an IC50 = 61 nM in a cell-free kinase assay (Blum, G., Gazit, A., and Levitzki, A. (2000) Biochemistry 39, 15705-15712). ...

AG 538 is a substrate-competitive inhibitor of the IGF-1 receptor (IGF-1R), with an IC50 = 61 nM in a cell-free kinase assay (Blum, …

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Synthesis of a novel macrocyclic library: discovery of an IGF-1R inhibitor.

Qvit N, Reuveni H, Gazal S, Zundelevich A, Blum G, Niv MY, Feldstein A, Meushar S, Shalev DE, Friedler A, Gilon C. Qvit N, et al. Among authors: blum g. J Comb Chem. 2008 Mar-Apr;10(2):256-66. doi: 10.1021/cc700113c. Epub 2008 Feb 14. J Comb Chem. 2008. PMID: 18271560

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Cathepsin B trafficking in thyroid carcinoma cells.

Tedelind S, Jordans S, Resemann H, Blum G, Bogyo M, Führer D, Brix K. Tedelind S, et al. Among authors: blum g. Thyroid Res. 2011 Aug 3;4 Suppl 1(Suppl 1):S2. doi: 10.1186/1756-6614-4-S1-S2. Thyroid Res. 2011. PMID: 21835049 Free PMC article.

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A nonpeptidic cathepsin S activity-based probe for noninvasive optical imaging of tumor-associated macrophages.

Verdoes M, Edgington LE, Scheeren FA, Leyva M, Blum G, Weiskopf K, Bachmann MH, Ellman JA, Bogyo M. Verdoes M, et al. Among authors: blum g. Chem Biol. 2012 May 25;19(5):619-28. doi: 10.1016/j.chembiol.2012.03.012. Chem Biol. 2012. PMID: 22633413 Free PMC article.

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Photodynamic quenched cathepsin activity based probes for cancer detection and macrophage targeted therapy.

Ben-Nun Y, Merquiol E, Brandis A, Turk B, Scherz A, Blum G. Ben-Nun Y, et al. Among authors: blum g. Theranostics. 2015 Apr 27;5(8):847-62. doi: 10.7150/thno.10854. eCollection 2015. Theranostics. 2015. PMID: 26000057 Free PMC article.

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α-Defensins Induce a Post-translational Modification of Low Density Lipoprotein (LDL) That Promotes Atherosclerosis at Normal Levels of Plasma Cholesterol.

Abu-Fanne R, Maraga E, Abd-Elrahman I, Hankin A, Blum G, Abdeen S, Hijazi N, Cines DB, Higazi AA. Abu-Fanne R, et al. Among authors: blum g. J Biol Chem. 2016 Feb 5;291(6):2777-86. doi: 10.1074/jbc.M115.669812. Epub 2015 Oct 30. J Biol Chem. 2016. PMID: 26518877 Free PMC article.

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Cathepsin Activity-Based Probes and Inhibitor for Preclinical Atherosclerosis Imaging and Macrophage Depletion.

Abd-Elrahman I, Kosuge H, Wises Sadan T, Ben-Nun Y, Meir K, Rubinstein C, Bogyo M, McConnell MV, Blum G. Abd-Elrahman I, et al. Among authors: blum g. PLoS One. 2016 Aug 17;11(8):e0160522. doi: 10.1371/journal.pone.0160522. eCollection 2016. PLoS One. 2016. PMID: 27532109 Free PMC article.

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Cathepsin nanofiber substrates as potential agents for targeted drug delivery.

Ben-Nun Y, Fichman G, Adler-Abramovich L, Turk B, Gazit E, Blum G. Ben-Nun Y, et al. Among authors: blum g. J Control Release. 2017 Jul 10;257:60-67. doi: 10.1016/j.jconrel.2016.11.028. Epub 2016 Nov 28. J Control Release. 2017. PMID: 27908759

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Cysteine proteases in atherosclerosis.

Weiss-Sadan T, Gotsman I, Blum G. Weiss-Sadan T, et al. Among authors: blum g. FEBS J. 2017 May;284(10):1455-1472. doi: 10.1111/febs.14043. Epub 2017 Mar 9. FEBS J. 2017. PMID: 28207191 Review.

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