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Discovery of novel polyamide-pyrrolobenzodiazepine hybrids for antibody-drug conjugates.
Thomas JD, Yurkovetskiy AV, Yin M, Bodyak ND, Gumerov DR, Tang S, Kelleher E, Jones BD, Protopopova M, Qin L, Uttard A, Demady DR, Lowinger TB. Thomas JD, et al. Among authors: bodyak nd. Bioorg Med Chem Lett. 2022 Sep 15;72:128876. doi: 10.1016/j.bmcl.2022.128876. Epub 2022 Jul 3. Bioorg Med Chem Lett. 2022. PMID: 35788036
The Dolaflexin-based Antibody-Drug Conjugate XMT-1536 Targets the Solid Tumor Lineage Antigen SLC34A2/NaPi2b.
Bodyak ND, Mosher R, Yurkovetskiy AV, Yin M, Bu C, Conlon PR, Demady DR, DeVit MJ, Gumerov DR, Gurijala VR, Lee W, McGillicuddy D, Park PU, Poling LL, Protopova M, Qin L, Stevenson CA, Ter-Ovanesyan E, Uttard A, Xiao D, Xu J, Xu L, Bergstrom DA, Lowinger TB. Bodyak ND, et al. Mol Cancer Ther. 2021 May;20(5):896-905. doi: 10.1158/1535-7163.MCT-20-0183. Epub 2021 Mar 15. Mol Cancer Ther. 2021. PMID: 33722858
35 results