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Chemical inhibitors of CYP450 enzymes in liver microsomes: combining selectivity and unbound fractions to guide selection of appropriate concentration in phenotyping assays.
Nirogi R, Palacharla RC, Uthukam V, Manoharan A, Srikakolapu SR, Kalaikadhiban I, Boggavarapu RK, Ponnamaneni RK, Ajjala DR, Bhyrapuneni G. Nirogi R, et al. Among authors: boggavarapu rk. Xenobiotica. 2015 Feb;45(2):95-106. doi: 10.3109/00498254.2014.945196. Epub 2014 Jul 29. Xenobiotica. 2015. PMID: 25070627
Inhibition of cytochrome P450 enzymes by saturated and unsaturated fatty acids in human liver microsomes, characterization of enzyme kinetics in the presence of bovine serum albumin (0.1 and 1.0% w/v) and in vitro - in vivo extrapolation of hepatic clearance.
Palacharla RC, Uthukam V, Manoharan A, Ponnamaneni RK, Padala NP, Boggavarapu RK, Bhyrapuneni G, Ajjala DR, Nirogi R. Palacharla RC, et al. Among authors: boggavarapu rk. Eur J Pharm Sci. 2017 Apr 1;101:80-89. doi: 10.1016/j.ejps.2017.01.027. Epub 2017 Feb 4. Eur J Pharm Sci. 2017. PMID: 28179134
Quantification of methyllycaconitine, selective α7 nicotinic receptor antagonist, in rodent plasma and brain tissue by liquid chromatography tandem mass spectrometry--application to neuropharmacokinetics of methyllycaconitine in rats.
Nirogi R, Kandikere V, Komarneni P, Aleti R, Boggavarapu R, Bhyrapuneni G, Muddana N, Mukkanti K. Nirogi R, et al. Biomed Chromatogr. 2011 Nov;25(11):1273-82. doi: 10.1002/bmc.1603. Epub 2011 Feb 18. Biomed Chromatogr. 2011. PMID: 21337354
A sensitive and selective quantification of catecholamine neurotransmitters in rat microdialysates by pre-column dansyl chloride derivatization using liquid chromatography-tandem mass spectrometry.
Nirogi R, Komarneni P, Kandikere V, Boggavarapu R, Bhyrapuneni G, Benade V, Gorentla S. Nirogi R, et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 15;913-914:41-7. doi: 10.1016/j.jchromb.2012.09.034. Epub 2012 Sep 27. J Chromatogr B Analyt Technol Biomed Life Sci. 2013. PMID: 23270937
12 results